Results 1 to 10 of about 67,105 (180)
Xanthine Oxidase-A Personal History. [PDF]
Molecules, 2023 A personal perspective is provided regarding the work in several laboratories, including the author’s, that has established the reaction mechanism of xanthine oxidase and related enzymes.
Hille R.
europepmc +6 more sources
Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase-catalyzed xanthine and 6-mercaptopurine oxidation. [PDF]
J Sci Food AgricAbstract BACKGROUND Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the treatment of hyperuricemia and gout, the potential application of phytochemicals has been widely studied.
Bencsik T +6 more
europepmc +2 more sources
Hepatology, EarlyView., 2022 A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan +19 more
wiley +1 more source
Xanthine dehydrogenase/xanthine oxidase and oxidative stress [PDF]
AGE, 1997 Xanthine dehydrogenase (XDH) and xanthine oxidase (XOD) are single-gene products that exist in separate but interconvertible forms. XOD utilizes hypoxanthine or xanthine as a substrate and O2 as a cofactor to produce superoxide (·O2 (-)) and uric acid.
Hae Young Chung +7 more
openaire +2 more sources
Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress [PDF]
, 2009 Oxidative stress plays an important role in the progression of vascular endothelial dysfunction. The two major systems generating vascular oxidative stress are the NADPH oxidase and the xanthine oxidase pathways. Allopurinol, a xanthine oxidase inhibitor,
George, Jacob, Struthers, Allan D.
core +3 more sources
Anti-gout potential of selected Malaysian local fruits [PDF]
, 2021 This study aimed to investigate the in vitro xanthine oxidase (XO) inhibitory activity and phytochemical content of guava, water rose apple, Malay gooseberry, pineapple and ambarella.
Abu Bakar +22 more
core +1 more source
Xanthine oxidase inhibitors and sepsis [PDF]
International Journal of Immunopathology and Pharmacology, 2018 Xanthine oxidase activation occurs in sepsis and results in the generation of uric acid (UrAc) and reactive oxygen species (ROS). We aimed to evaluate the effect of xanthine oxidase inhibitors (XOis) in rats stimulated with lipopolysaccharide (LPS). LPS (10 mg/kg) was administered intraperitoneally (i.p.) immediately after allopurinol (Alo, 2 mg/kg ...
Clara Versolato Razvickas +4 more
openaire +3 more sources
Reductive activation of potential antitumor bis(aziridinyl)benzoquinones by xanthine oxidase: Competition between oxygen reduction and quinone reduction [PDF]
, 1990 The reduction of a series of 2,5-bis(1-aziridinyl)-1,4-benzoquinone (BABQ) derivatives with various 3,6 substituents by the enzyme xanthine oxidase has been studied.
Janssen, L.H.M. +5 more
core +3 more sources
Detection of superoxide anion radical in phospholipid liposomal membrane by fluorescence quenching method using 1,3-diphenylisobenzofuran [PDF]
, 1999 Utilization of a fluorescence dye, 1,3-diphenylisobenzofuran (DPBF) as a detector of superoxide anion radical (O⋅−2) was examined. The fluorescence intensity of DPBF incorporated in phospholipid liposomes consisting of phosphatidylcholine (PC) and ...
Katoh, Takafumi +2 more
core +1 more source
, 2008 INTRODUCTION: Gout affects about 5% of men and 1% of women, with up to 80% of people experiencing a recurrent attack within 3 years. METHODS AND OUTCOMES:We conducted a systematic review and aimed to answer the following clinical questions: What are the
Underwood, Martin
core +3 more sources