Results 71 to 80 of about 300,913 (307)

7-Keto-Cholesterol and Cholestan-3beta, 5alpha, 6beta-Triol Induce Eryptosis through Distinct Pathways Leading to NADPH Oxidase and Nitric Oxide Synthase Activation [PDF]

, 2019
BACKGROUND/AIMS: We showed that patho-physiological concentrations of either 7-keto-cholesterol (7-KC), or cholestane-3beta, 5alpha, 6beta-triol (TRIOL) caused the eryptotic death of human red blood cells (RBC), strictly dependent on the early production
Allegra M., Attanzio A., Cilla A., Frazzitta A., Livrea M. A., Tesoriere L.   +5 more
core   +1 more source

Identification of Chemical Compounds in Black Garlic Extract and Effect on Inhibiting Xanthine Oxidase Enzyme

Jurnal Pijar MIPA (Pengkajian Ilmu dan Pengajaran Matematika dan Ilmu Pengetahuan Alam)
Xanthine oxidase is an enzyme involved in the catalysis of the oxidation reaction that converts hypoxanthine into xanthine and subsequently into uric acid. Elevated uric acid levels can pose various health risks.
Mahrunisa Nur Afifah, Nuniek Herdyastuti
doaj   +1 more source

In vitro investigation of xanthine oxidase inhibitory and antioxidant activities of 3,4,5-trihydroxycinnamic acid [PDF]

Journal of HerbMed Pharmacology
Introduction: Xanthine oxidase inhibitors with strong antioxidant activity are promising candidates for the treatment of gout and reactive oxygen species (ROS)-related disorders.
Taweesak Dhammaraj, Phoobet Kotseekieo, Tunnathon Chotikarn, Narumol Phosrithong, Wattanakarn Praison, Tossapol Prasomsub, Panupong Lumthong, Warangrat Supaporn, Bunleu Sungthong, Chawannuch Mudjupa, Pawitra Pulbutr   +10 more
doaj   +1 more source

Xanthine Oxidase Inhibition by Febuxostat Attenuates Experimental Atherosclerosis in Mice

Scientific Reports, 2014
Atherosclerosis is a chronic inflammatory disease due to lipid deposition in the arterial wall. Multiple mechanisms participate in the inflammatory process, including oxidative stress.
Johji Nomura, N. Busso, A. Ives, Chieko Matsui, Syunsuke Tsujimoto, Takashi Shirakura, Mizuho Tamura, Tsunefumi Kobayashi, A. So, Yoshihiro Yamanaka   +9 more
semanticscholar   +1 more source

A Targeted Redox‐Active Dual‐Action Pt(IV)‐Mn(II) Prodrug Displays Enhanced In Vivo Anticancer Activity

Advanced Healthcare Materials, EarlyView.
A new oxaliplatin‐based Pt(IV) prodrug bearing a Mn(II) superoxide dismutase mimic is synthesized and studied, in vitro and in vivo, in the context of colorectal cancer. Encapsulation of this prodrug in an easy‐to‐implement PEGylated micelle formulation demonstrated the highest in vivo anticancer activity among all the tested conditions, supporting the
Alvaro Lopez‐Sanchez, Henri Chédotal, Ram Pravin Kumar Muthuramalingam, Marine Thomas, Jia Ning Nicolette Yau, Priya Ranjan Sahoo, Clotilde Policar, Frédéric Batteux, Kadda Medjoubi, Andrea Somogyi, Giulia Adriani, Carole Nicco, Romain Coriat, Giorgia Pastorin, Hélène C. Bertrand   +14 more
wiley   +1 more source

Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death. [PDF]

, 2015
Leydig cells are crucial to the production of testosterone in males. It is unknown if the cancer chemotherapeutic drug, 6-mercaptopurine (6 MP), produces Leydig cell failure among adult survivors of childhood acute lymphoblastic leukemia. Moreover, it is
Bao, Ju, Chemaitilly, Wassim, Frase, Sharon, Green, Daniel M, Janke, Laura, Lynch, John, Morgan, Jessica A, Opferman, Joseph T, Panetta, John C, Schuetz, John D, Wang, Yao, Zheng, Jie   +11 more
core   +1 more source

Zinc‐Coordinated Trienzyme Nanogel Cascade Therapy for Accelerated Post‐Pancreatectomy Cutaneous Wound Healing

Advanced Materials, EarlyView.
A zinc‐coordinated nanogel assembly is reported that co‐delivers three enzymes to regulate glucose, oxidative stress, and oxygen levels. This system mimics natural enzyme cascades to reprogram the wound environment after pancreatectomy. In a post‐pancreatectomy mouse model, it accelerates healing by reducing infection, promoting blood vessel growth ...
Yedong Ma, Chengke Xie, Chengyu Liao, Binting Huang, Siqi Liu, Junhua Kong, Xiaotong Fan, Zibiao Li, Shi Chen, Chaobin He   +9 more
wiley   +1 more source

Caffeine affects the biological responses of human hematopoietic cells of myeloid lineage via downregulation of the mTOR pathway and xanthine oxidase activity [PDF]

, 2015
Correction of human myeloid cell function is crucial for the prevention of inflammatory and allergic reactions as well as leukaemia progression. Caffeine, a naturally occurring food component, is known to display anti-inflammatory effects which have ...
Abooali, Maryam, Berger, Steffen M., Casely-Hayford, Maxwell A., Fasler-Kan, Elizaveta, Gibbs, Bernhard F., Gonçalves Silva, Isabel, Prokhorov, Alexandr, Sumbayev, Vadim V., Yasinska, Inna M.   +8 more
core   +3 more sources

PENGHAMBATAN AKTIVITAS XANTHINE OXIDASE OLEH EKSTRAK ETANOL SARANG SEMUT (Myrmecodia tuberosa (non Jack) Bl.) SECARA IN VITRO

Pharmaciana, 2014
Uric acid is the end product of purine metabolism that can settle in the joints and form small crystals, causing inflammation known as gout. Gout is a disease caused by high levels of uric acid in the blood (hyperuricemia).
Ernawati Ernawati, Hari Susanti
doaj   +1 more source

Xanthine Oxidase: Isolation, Assays of Activity, and Inhibition

, 2015
Xanthine oxidase (XO) is an important enzyme catalyzing the hydroxylation of hypoxanthine to xanthine and xanthine to uric acid which is excreted by kidneys. Excessive production and/or inadequate excretion of uric acid results in hyperuricemia.
D. Kostić, Danica S. Dimitrijević, G. Stojanović, Ivan R. Palić, A. Đorđević, Jovana D. Ickovski   +5 more
semanticscholar   +1 more source