Results 71 to 80 of about 79,386 (326)

Adropin modulates pancreatic cell proliferation and glutathione levels in an animal model of type 1 diabetes mellitus

Animal Models and Experimental Medicine, EarlyView.
Adropin is related to the energy homeostasis‐associated gene. It significantly increased glutathione reductase enzyme levels in the pancreas of experimental diabetic rats. Adropin may reduce the severity of diabetes and its complications. Cell proliferation in the exocrine is reduced after the administration of adropin.
Ifrah I. Ali, Crystal D'Souza, Abderrahim Nemmar, Shreesh Ojha, Ernest A. Adeghate   +4 more
wiley   +1 more source

PENGHAMBATAN AKTIVITAS XANTHINE OXIDASE OLEH EKSTRAK ETANOL AKAR SAMBILOTO (Andrographis paniculata, Ness) SECARA IN VITRO

Pharmaciana, 2012
Sambiloto root of which contained of flavonoids used by the people for traditional medicine. In the previous publication, an effective xanthine oxidase inhibitory activity of flavonoids was reported.
Ulfah Septianingsih, Hari Susanti, Wahyu Widyaningsih   +2 more
doaj   +1 more source

Identification of a new mutation in the human xanthine dehydrogenase responsible for xanthinuria type I

Advances in Laboratory Medicine, 2021
Hereditary xanthinuria is a rare, autosomal and recessive disorder characterized by severe hypouricemia and increased xanthine excretion, caused by a deficiency of xanthine dehydrogenase/oxidase (XDH/XO, EC: 1.17.1.4/1.17.3.2) in type I, or by a ...
Collazo Abal Cristina, Romero Santos Susana, González Mao Carmen, Pazos Lago Emilio C., Barros Angueira Francisco, Castiñeiras Ramos Daisy   +5 more
doaj   +1 more source

Optimization of Ultrasonic-assisted Two-aqueous Extraction of Flavonoids from Rosa roxburghii Tratt and Its Inhibitory Effect on Xanthine Oxidase Activity

Shipin gongye ke-ji, 2023
In this study, ultrasound-assisted aqueous two-phase extraction (UA-ATPE) was adopted to extract flavonoids from Rosa roxburghii Tratt and investigated its inhibitory effect of this flavonoid on xanthine oxidase activity in vitro.
Qianfei ZHUANG, Dandan LIU, Zeyu CHEN, Zufei SHANG, Xiaoyan LIU, Lizhi MA   +5 more
doaj   +1 more source

Establishment of a mouse model of TMAO‐induced cardiac injury and application of MICT intervention

Animal Models and Experimental Medicine, EarlyView.
This study aims to explore the establishment of an animal model of cardiac injury induced by trimethylamine‐N‐oxide (TMAO), a metabolite secreted by gut microorganisms, and to investigate its application in moderate‐intensity continuous training (MICT) intervention.
Zhongping Xie, Hong Zou, Lijing Gong, Minghui Lin, Caihua Huang   +4 more
wiley   +1 more source

Effects of Polyphenols on Oxidative Stress-Mediated Injury in Cardiomyocytes [PDF]

, 2017
Cardiovascular diseases are the main cause of mortality and morbidity in the world. Hypertension, ischemia/reperfusion, diabetes and anti-cancer drugs contribute to heart failure through oxidative and nitrosative stresses which cause cardiomyocytes ...
Bei, Roberto, Benvenuto, Monica, Bergante, Sonia, Giganti, Maria Gabriella, Manzari, Vittorio, Masuelli, Laura, Mattera, Rosanna, Modesti, Andrea, Pluchinotta, Francesca Romana, Tettamanti, Guido, Tresoldi, Ilaria   +10 more
core   +2 more sources

Establishment of a novel cynomolgus monkey model of hyperuricemia

Animal Models and Experimental Medicine, EarlyView.
We established a novel hyperuricemia model in cynomolgus monkeys (A) via oral administration of potassium oxonate, hydrochlorothiazide, and adenine mixed in fruits and vegetables. This model (B) targets uric acid synthesis and enzymatic degradation, and (C) regulates renal and intestinal excretion, thereby stably elevating serum uric acid and serving ...
Ji‐Wei Wang, Le Zhang, Can Yang, Guan‐Cong Luo, Rui‐Chang Liu, Yan‐Jun Xu, Sheng Cheng, Wen‐Yu Jiang, Richard Ward, Yang Yang, Cheng Xiang, Shu An, Tian‐Rui Xu   +12 more
wiley   +1 more source

Ipomea aquatica EXTRACT INHIBITS LIPOXYGENASE, HYALURONIDASE AND XANTHINE OXIDASE ACTIVITIES

Journal of Academia, 2020
Ipomea aquatica, locally known as water spinach, is one of the most common vegetable consumed by Malaysian. I. aquatica exhibited several biological activities including free radical scavenging, anti-microbial and anti-proliferative.
Muhammad Helmi Nadri
doaj  

Antioxidant potential and xanthine oxidase inhibition of flavonol glycosides from Phyllanthus emblica L. leaves [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Hyperuricemia is the cause of gout in the inflammatory joint condition. The xanthine oxidase enzyme is a therapeutic target for gout treatment because it plays a role in the generation of uric acid. Allopurinol is used to treat gout. It prevents
Husnunnisa, Rika Hartati, Rachmat Mauludin, Muhamad Insanu   +3 more
doaj   +1 more source

In Vitro α-Amylase, α-Glucosidase, Pancreatic Lipase, Xanthine Oxidase Inhibiting Activity of Agaricus bisporus Extracts

Mycobiology, 2023
In this study, the α-amylase inhibitory activity, α-glucosidase inhibitory activity, pancreatic lipase inhibitory activity, and Xanthine Oxidase inhibitory activity of the fruiting body extracts of 5 varieties of Agaricus bisporus (AB) were confirmed ...
Jung Han Kim, Myoung Jun Jang, Youn Jin Park   +2 more
doaj   +1 more source