Results 81 to 90 of about 300,913 (307)
In silico design and synthesis of hesperitin derivatives as new xanthine oxidase inhibitors
BMC Chemistry, 2019 Background Hesperitin, a naturally occurring flavonoid was hybridized with phenolic acids to evaluate its potential to inhibit the activity of xanthine oxidase (XO), a key enzyme which catalyses xanthine to uric acid which is found to be associated with ...
Neelam Malik +2 more
doaj +1 more source
Cardiovascular Therapeutics, 2014 MeSH Antioxidants /therapeutic use; Biomarkers /blood; Cardiovascular Agents /therapeutic use; Cardiovascular Diseases /blood /drug therapy /enzymology /physiopathology; Endothelium, Vascular /drug effects /metabolism /physiopathology; Enzyme Inhibitors /
Jufen Zhang, R. Dierckx, J. Cleland
semanticscholar +1 more source
Bioelectrosynthesis of Signaling Molecules for Selective Modulation of Cell Signaling
Angewandte Chemie International Edition, Accepted Article.Bioelectrosynthesis holds great potential for studying and regulating biological systems through the in situ synthesis and delivery of cell signaling molecules with high spatiotemporal precision. Despite recent advancements, precise control over multiple signaling molecules within a single platform remains challenging.
Myeongeun Lee +6 more
wiley +1 more source
Pharmaceutics, 2022 Gout is a common metabolic disease caused by abnormal purine metabolism that promotes the formation and deposition of monosodium urate crystals within joints that causes acute arthritis and can seriously affect the daily life of patients.
Chi-Ya Huang +3 more
doaj +1 more source
Sensitive superoxide detection in vascular cells by the new chemiluminescence dye L-012 [PDF]
, 1999 The detection superoxide production in vascular cells is usually limited by a low sensitivity of available assays, We tested the applicability of the luminol derivate L-012 {[}8-amino-5-chloro-7-phenylpyridol{[}3,4-d]pyridazine-l,4(2H,3H)dione] to ...
Gloe, Torsten +4 more
core +1 more source
Pakistan Journal of Medical Sciences, 2014 Objective: To examine the effect of smoking on serum xanthine oxidase, malondialdehyde, α- tocopherol and ascorbic acid levels in healthy adult male subjects.
Ali Akbar Shah +2 more
semanticscholar +1 more source
Arthritis &Rheumatology, Accepted Article.Objectives Dotinurad is a selective urate reabsorption inhibitor that reduces serum urate levels. We compared the efficacy and safety of dotinurad with febuxostat in Chinese patients with gout. Methods This phase 3, multicentre, randomised, double‐blind, parallel‐group study randomly allocated (1:1) eligible patients with gout to receive oral dotinurad
Jia Sun +19 more
wiley +1 more source
Diabetic Cardiovascular Disease Induced by Oxidative Stress. [PDF]
, 2015 Cardiovascular disease (CVD) is the leading cause of morbidity and mortality among patients with diabetes mellitus (DM). DM can lead to multiple cardiovascular complications, including coronary artery disease (CAD), cardiac hypertrophy, and heart failure
Adam, Matti +9 more
core +2 more sources
Pharmaciana, 2012 Sambiloto root of which contained of flavonoids used by the people for traditional medicine. In the previous publication, an effective xanthine oxidase inhibitory activity of flavonoids was reported.
Ulfah Septianingsih +2 more
doaj +1 more source
Journal of clinical biochemistry and nutrition, 2014 The twin character of reactive oxygen species is substantiated by a growing body of evidence that reactive oxygen species within cells act as inducers and accelerators of the oncogenic phenotype of cancer cells, while reactive oxygen species can also ...
S. Sakuma +3 more
semanticscholar +1 more source