Results 81 to 90 of about 78,058 (260)

Phenolic metabolites of anthocyanins modulate mechanisms of endothelial function [PDF]

open access: yes, 2015
Anthocyanins are reported to have vascular bioactivity, however their mechanisms of action are largely unknown. Evidence suggests that anthocyanins modulate endothelial function, potentially by increasing nitric oxide (NO) synthesis, or enhancing NO ...
Cassidy, Aedin   +4 more
core   +1 more source

Abnormal early cleavage events predict early embryo demise: sperm oxidative stress and early abnormal cleavage. [PDF]

open access: yes, 2014
Human embryos resulting from abnormal early cleavage can result in aneuploidy and failure to develop normally to the blastocyst stage. The nature of paternal influence on early embryo development has not been directly demonstrated although many studies ...
Barker, Christopher M   +4 more
core   +2 more sources

KHẢO SÁT KHẢ NĂNG ỨC CHẾ ENZYME XANTHINE OXIDASE TỪ LÁ SA KÊ (ARTOCARPUS ALTILIS (PARK.) FOSB)

open access: yesTạp chí Khoa học Đại học Cần Thơ, 2014
Tăng acid uric không chỉ là nguyên nhân gây nên bệnh gout, mà còn làm tăng nguy cơ bệnh tim mạch, sỏi thận, đái tháo đường và các hội chứng chuyển hóa.
Đái Thị Xuân Trang   +2 more
doaj  

Summer Savory (Satureja hortensis) Extract Inhibits Xanthine Oxidase [PDF]

open access: yesJournal of Medicinal Plants and By-products, 2015
Xanthine oxidase plays crucial roles in the production of reactive oxygen species (ROS), and uric acid in blood which may lead to gout, one of the oldest known forms of arthritis amongst humans.
Yeganeh Teimoori-Boghsani   +3 more
doaj  

2-Styrylchromones as novel inhibitors of xanthine oxidase. A structure-activity study [PDF]

open access: yes, 2002
The purpose of this study was the evaluation of the xanthine oxidase (XO) inhibition produced by some synthetic 2-styrylchromones. Ten polyhydroxylated derivatives with several substitution patterns were synthesised, and these and a positive control,
Bastos, Maria de Lourdes   +6 more
core   +1 more source

Myo‐Inositol Mitigates Oxidative Stress in Bovine Mammary Epithelial Cells via Activation of the SIRT5/Nrf2 Signaling Axis

open access: yesAnimal Research and One Health, EarlyView.
Myo‐inositol alleviates oxidative stress in dairy cow mammary epithelial cells via the Sirt5/Nrf2 pathway to promote mitochondrial fusion. This graphical abstract was created with BioRender.com. ABSTRACT High‐yielding dairy cows are susceptible to mammary gland oxidative stress due to prolonged intensive lactation, leading to redox imbalance.
Yufei Zhang   +8 more
wiley   +1 more source

The Role of System-Specific Molecular Chaperones in the Maturation of Molybdoenzymes in Bacteria

open access: yesBiochemistry Research International, 2011
Biogenesis of prokaryotic molybdoenzymes is a complex process with the final step representing the insertion of a matured molybdenum cofactor (Moco) into a folded apoenzyme.
Meina Neumann, Silke Leimkühler
doaj   +1 more source

Attenuation of ischemic liver injury by prostaglandin E1 analogue, misoprostol, and prostaglandin I2 analogue, OP-41483 [PDF]

open access: yes, 1998
Background: Prostaglandin has been reported to have protective effects against liver injury. Use of this agent in clinical settings, however, is limited because of drugrelated side effects.
Ishizaki, N   +8 more
core   +1 more source

Efficacy and Safety of Dotinurad Versus Febuxostat for the Treatment of Gout: A Randomized, Multicenter, Double‐Blind, Phase 3 Trial in China

open access: yesArthritis &Rheumatology, EarlyView.
Objective Dotinurad is a selective urate reabsorption inhibitor that reduces serum urate levels. We compared the efficacy and safety of dotinurad with febuxostat in Chinese patients with gout. Methods This phase 3, multicenter, randomized, double‐blind, parallel‐group study randomly allocated (1:1) eligible patients with gout to receive oral dotinurad ...
Jia Sun   +19 more
wiley   +1 more source

Optimization of the Extraction Conditions and Biological Evaluation of Dendropanax morbifera H. Lev as an Anti-Hyperuricemic Source

open access: yesMolecules, 2018
Dendropanax morbifera H. Levis a medicinal plant native to South Korea, East Asia, and South America. Among some 75 species, one species grows in Korea. In previous studies, D.
Seung-Sik Cho   +5 more
doaj   +1 more source

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