Results 41 to 50 of about 44,980 (368)

A new insight into the oxidative mechanism of caffeine and related methylxanthines in aprotic medium: May caffeine be really considered as an antioxidant? [PDF]

open access: yes, 2018
Background: Antioxidant properties have been recently suggested for caffeine that seems showing protective effects against damages caused by oxidative stress. In particular, a HO% scavenging activity has been ascribed to caffeine. Even if the oxidation
Curulli, Antonella   +3 more
core   +1 more source

Protein kinase a distribution differentiates human glioblastoma from brain tissue [PDF]

open access: yes, 2017
Brain tumor glioblastoma has no clear molecular signature and there is no effective therapy. In rodents, the intracellular distribution of the cyclic AMP (cAMP)-dependent protein kinase (Protein kinase A, PKA) R2Alpha subunit was previously shown to ...
Caretta, Antonio   +3 more
core   +2 more sources

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

open access: yesHepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan   +19 more
wiley   +1 more source

Multi-target Natural and Nature-Inspired Compounds against Neurodegeneration: A Focus on Dual Cholinesterase and Phosphodiesterase Inhibitors

open access: yesApplied Sciences, 2021
Alzheimer’s disease is a memory-related neurodegenerative condition leading to cognitive impairment. Cholinergic deficit, together with other underlying mechanisms, leads the to onset and progression of the disease.
Giovanni Ribaudo   +2 more
doaj   +1 more source

Caffeine. cognitive and physical performance enhancer or psychoactive drug? [PDF]

open access: yes, 2015
Caffeine use is increasing worldwide. The underlying motivations are mainly concentration and memory enhancement and physical performance improvement. Coffee and caffeine-containing products affect the cardiovascular system, with their positive inotropic
Aromatario, Mariarosaria   +3 more
core   +1 more source

Drug Delivery Systems: Study of Inclusion Complex Formation between Methylxanthines and Cyclodextrins and Their Thermodynamic and Transport Properties

open access: yesBiomolecules, 2019
This paper presents an analysis of the molecular mechanisms involved in the formation of inclusion complexes together with some structural interpretation of drug−carrier molecule interactions in aqueous multicomponent systems comprising ...
Cecília I. A. V. Santos   +2 more
doaj   +1 more source

What do we know about the sleep effects of caffeine used to treat apnoea of prematurity? A systematic review of the literature

open access: yesMolecular and Cellular Pediatrics, 2023
Objective Scientific scrutiny has proved the safety and benefits of caffeine to treat apnoea of prematurity (AOP). However, there is no consensus on the effects of this treatment on sleep, especially considering the key role of adenosine and early brain ...
Ana Renata Pinto de Toledo   +5 more
doaj   +1 more source

Patient-physician discordance in assessment of adherence to inhaled controller medication: a cross-sectional analysis of two cohorts [PDF]

open access: yes, 2019
We aimed to compare patient's and physician's ratings of inhaled medication adherence and to identify predictors of patient-physician discordance.(SFRH/BPD/115169/2016) funded by Fundação para a Ciência e Tecnologia (FCT); ERDF (European Regional ...
Afonso, Ivete   +68 more
core   +3 more sources

Camellia sinensis, a natural product to support the treatment of medical and stomatological conditions

open access: yesJournal of Oral Research, 2023
Introduction: The tea plant, Camellia sinensis, is one of the most popular non-alcoholic beverages in the world. The main components of Camellia sinensis include amino acids, fatty acids, phenolic compounds, flavins and purine alkaloids (xanthines).
Ricardo Reyes-Mansilla   +2 more
doaj   +1 more source

Medications that relax the lower oesophageal sphincter and risk of oesophageal cancer : An analysis of two independent population-based databases [PDF]

open access: yes, 2018
Acknowledgements We acknowledge collaboration with the Research Applications and Data Management Team lead by Ms Katie Wilde, University of Aberdeen in conducting our study.
Busby, John   +11 more
core   +2 more sources

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