Results 41 to 50 of about 16,457 (321)
Synthesis of 2-Substituted 9-Oxa-Guanines {5-Aminooxazolo 5,4-D Pyrimidin-7(6H)-Ones} and 9-Oxa-2-Thio-Xanthines{5-Mercaptooxazolo 5,4-D Pyrimidin-7(6H)-Ones} [PDF]
, 2008 Oxazolo[5,4-d] pyrimidines can be considered as 9-oxa-purine analogs of naturally occurring nucleic acid bases. Interest in this ring system has increased due to recent reports of biologically active derivatives.
Bai, Yan +4 more
core +3 more sources
Xanthine urolithiasis: Inhibitors of xanthine crystallization
PLOS ONE, 2018 AbstractOBJECTIVETo identify in vitro inhibitors of xanthine crystallization that have potential for inhibiting the formation of xanthine crystals in urine and preventing the development of the renal calculi in patients with xanthinuria.METHODSThe formation of xanthine crystals in synthetic urine and the effects of 10 potential crystallization ...
Grases, Felix +3 more
openaire +5 more sources
Hepatology, EarlyView., 2022 A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan +19 more
wiley +1 more source
FEBS Open Bio, 2019 In eukaryotic cells, cytoplasmic mRNA is characterised by a 3′ poly(A) tail. The shortening and removal of poly(A) tails (deadenylation) by the Ccr4‐Not nuclease complex leads to reduced translational efficiency and RNA degradation.
Blessing Airhihen +4 more
doaj +1 more source
Patient-physician discordance in assessment of adherence to inhaled controller medication: a cross-sectional analysis of two cohorts [PDF]
, 2019 We aimed to compare patient's and physician's ratings of inhaled medication adherence and to identify predictors of patient-physician discordance.(SFRH/BPD/115169/2016) funded by Fundação para a Ciência e Tecnologia (FCT); ERDF (European Regional ...
Afonso, Ivete +68 more
core +3 more sources
Xanthines Studied via Femtosecond Fluorescence Spectroscopy
Molecules, 2016 Xanthines represent a wide class of compounds closely related to the DNA bases adenine and guanine. Ubiquitous in the human body, they are capable of replacing natural bases in double helices and give rise to four-stranded structures. Although the use of
Pascale Changenet-Barret +3 more
doaj +1 more source
Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders
Marine Drugs, 2021 Marine habitats offer a rich reservoir of new bioactive compounds with great pharmaceutical potential; the variety of these molecules is unique, and its production is favored by the chemical and physical conditions of the sea.
Mariano Catanesi +5 more
doaj +1 more source
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2016 Introduction. Analysis of last years’ literature shows, that the most wide spread drugs are those, which contain in their structures heterocyclic fragment.
K. V. Аleksandrova +3 more
doaj +1 more source
Clay body wrap with microcurrent: effects in central adiposity [PDF]
, 2013 Introduction Increased fat mass is becoming more prevalent in women and its accumulation in the abdominal region can lead to numerous health risks such as diabetes mellitus.
Couto, Miriam F. +4 more
core +1 more source
Biomolecules, 2019 This paper presents an analysis of the molecular mechanisms involved in the formation of inclusion complexes together with some structural interpretation of drug−carrier molecule interactions in aqueous multicomponent systems comprising ...
Cecília I. A. V. Santos +2 more
doaj +1 more source