Photoelektrochemische Eisen(III)‐Katalyse für C─H‐Fluoralkylierungen im synthetischen Spätstadium
Angewandte Chemie, EarlyView.Eine effiziente elektrophotochemische C─H‐Fluoralkylierung von komplexen bioaktiven Verbindungen mit verfügbaren Fluoralkylcarbonsäuren unter Verwendung eines günstigen Eisen(III)‐Katalysators begleitet von der Wasserstoffentwicklungsreaktion wurde entwickelt.
Vladimir Motornov +8 more
wiley +1 more source
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
Urinary tract infection is associated with hypokalemia: a case control study
BMC Urology, 2020 Background Hypokalemia is a common clinical problem. The association between urinary tract infection (UTI) and hypokalemia is not clear. Hypokalemia is common in patients with UTI in clinical observation.
Ai-Ling Shen +5 more
doaj +1 more source
The action of xanthin and methyl xanthins on the isolated intestine
Experimental Biology and Medicine, 1916 The tests were made with different concentrations of xanthin and its derivatives dissolved in Locke's solution which were carried out on segments of different parts of the intestine of the rabbit. Sodium xanthin in concentrations of 1 : 2,000 and 1 : 1,000 caused increased tonus which was more pronounced in the large than in the small intestine.
William Salant, E. W. Schwartze
openaire +2 more sources
Assessment of pediatric asthma drug use in three European countries; a TEDDY study. [PDF]
, 2010 Asthma drugs are amongst the most frequently used drugs in childhood, but international comparisons on type and indication of use are lacking. The aim of this study was to describe asthma drug use in children with and without asthma in the Netherlands ...
A Clavenna +48 more
core +3 more sources
Red blood cell endothelial nitric oxide synthase: A major player in regulating cardiovascular health
British Journal of Pharmacology, EarlyView., 2023 Abstract Red blood cells (RBCs) have traditionally been seen as simple carriers of gases and nutrients in the body. One important non‐canonical function of RBCs in the cardiovascular system is the regulation of nitric oxide (NO) metabolism. It has been shown that RBCs can scavenge NO, transport NO metabolites and produce NO in hypoxic conditions ...
Anthea LoBue +7 more
wiley +1 more source
Effect of ELF e.m. fields on metalloprotein redox-active sites [PDF]
arXiv, 2008 The peculiarity of the distribution and geometry of metallic ions in enzymes pushed us to set the hypothesis that metallic ions in active-site act like tiny antennas able to pick up very feeble e.m. signals. Enzymatic activity of Cu2+, Zn2+ Superoxide Dismutase (SOD1) and Fe2+ Xanthine Oxidase (XO) has been studied, following in vitro generation and ...
arxiv
Photoelectrochemical Iron(III) Catalysis for Late‐Stage C─H Fluoroalkylations
Angewandte Chemie International Edition, EarlyView.Efficient electrophotochemical C─H fluoroalkylation of complex bioactive substrates with abundant fluoroalkyl carboxylic acids employing an inexpensive iron(III) catalyst accompanied by hydrogen evolution reaction has been developed. Abstract Chemo‐ and site‐selective functionalization of complex molecules poses a fundamental challenge.
Vladimir Motornov +8 more
wiley +1 more source
Synthesis, biological evaluation and Structure Activity Relationships (SARs) study of 8-(substituted)aryloxycaffeine [PDF]
, 2015 A series of 8-(substituted)aryloxycaffeine were prepared from 8-bromocaffeine and (substituted)phenols by modified Ullmann reaction. In vitro antibacterial activity, inhibitory activity on topoisomerase II and pharmacological activities were evaluated ...
El-Tahir, Kamal E.H. +3 more
core +1 more source
Identification of selective small molecule inhibitors of the nucleotide-binding oligomerization domain 1 (NOD1) signaling pathway. [PDF]
PLoS ONE, 2014 NOD1 is an intracellular pattern recognition receptor that recognizes diaminopimelic acid (DAP), a peptidoglycan component in gram negative bacteria. Upon ligand binding, NOD1 assembles with receptor-interacting protein (RIP)-2 kinase and initiates a ...
David J Rickard +14 more
doaj +1 more source