Results 81 to 90 of about 6,368 (267)

Inosine triphosphate pyrophosphatase activity as a potential predictor of methotrexate remission in juvenile idiopathic arthritis

Arthritis &Rheumatology, Accepted Article.
Background Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients don't respond. Low inosine‐triphosphate‐pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated ITPA role and the underlying mechanisms in vitro.
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

SYNTHESIS AND PHYSICAL-CHEMICAL PROPERTIES OF WATER-SOLUBLE 3-BENZYLXANTHINE DERIVATIVES

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2015
Introduction Nowadays, research of novel biological active compounds with low toxicity, are carried out among different classes of organic compounds of natural and synthetic genesis.
K. V. Аleksandrova, S. V. Levich, O. S. Shkoda, D. M. Yurchenko   +3 more
doaj   +1 more source

Xanthine oxidoreductase and xanthine oxidase in human cornea.

Histology and histopathology, 2002
Xanthine oxidoreductase (xanthine dehydrogenase + xanthine oxidase) is a complex enzyme that catalyzes the oxidation of hypoxanthine to xanthine, subsequently producing uric acid. The enzyme complex exists in separate but interconvertible forms, xanthine dehydrogenase and xanthine oxidase, which generate reactive oxygen species (ROS), a well known ...
Cejkova, J., Ardan, T., Filipec, M., Midelfart, A.   +3 more
openaire   +3 more sources

Criterios para determinar la edad de pollos de Flamenco Austral (Phoenicopterus chilensis) en cautiverio basadas en características del plumaje [PDF]

, 2018
Many aspects of the breeding biology of the Chilean Flamingo (Phoenicopterus chilensis) are still unknown. We studied captive breeding Chilean Flamingos at La Plata Zoo, Buenos Aires, Argentina between February and July 2014 to document chick‐aging ...
Chiale, Maria Cecilia, Maragliano, María Graciela, Montalti, Diego   +2 more
core  

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Synthesis and physical-chemical properties of 3-benzyl-8-(5-mercapto-4-phenyl-[1,2,4]-triazole-3-ylmethylthiomethyl)xanthine and its s-substituted derivatives

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2015
Aim. Currently, researches, devoted to obtain new active compounds, are carried out among various classes of organic compounds, and combination of several active heterocyclic fragments in one molecule is considered the key way in such researches ...
K. V. Аleksandrova, A. S. Shkoda, S. V. Levich, M. V. Dyachkov, D. M. Yurchenko   +4 more
doaj   +1 more source

Cardiovascular and metabolic responses to the ingestion of caffeinated herbal tea: drink it hot or cold? [PDF]

, 2018
Tea is usually consumed at two temperatures (as hot tea or as iced tea). However, the importance of drink temperature on the cardiovascular system and on metabolism has not been thoroughly investigated.
Dulloo, Abdul G., Maufrais, Claire, Montani, Jean-Pierre, Sarafian, Delphine   +3 more
core   +4 more sources

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Xanthine Accumulation during Hypoxanthine Oxidation by Milk Xanthine Oxidase [PDF]

European Journal of Biochemistry, 1973
Accumulation of xanthine as well as uric acid, was found as a result of hypoxanthine oxidation by xanthine: oxygen oxidoreductase from milk. The ratio xanthine/uric acid increases with hypoxanthine concentration, and decreases with the enzyme concentration and the reaction time.
openaire   +2 more sources

Physician-prescribed Asthma Treatment Regimen does not differ Between Smoking and Non-smoking Patients With Asthma in Seoul and Gyunggi province of Korea [PDF]

, 2014
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any ...
Chalmers, Chaudhuri, Chaudhuri, Cho, Clatworthy, David Price, Fauler, Felicia Allen-Ramey, Hae-Sim Park, Jang, Jang, Kerstjens, Ki-Suck Jung, Kian Fan Chung, Kim, Lazarus, Lee, Masoli, O'Byrne, Oh, Park, Price, Rayens, Richard Perry, Ryan Pollard, Thomson, Thomson, Zainudin   +27 more
core   +2 more sources