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Genetic diversity of chemokine XCL1 and its receptor XCR1 in murine rodents
Developmental and Comparative Immunology, 2019The chemokine ligand XCL1 plays critical roles in immune responses with diverse physiological and pathological implications through interactions with a cognate G protein-coupled receptor XCR1. To shed insight into their versatile nature, we analyzed genetic variations of XCL1 and XCR1 in murine rodents, including commonly-used model organisms Mus ...
Bo Zeng, Cody W Thompson, Yan Li
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CXCL10/XCL1 fusokine elicits in vitro and in vivo chemotaxis
Biotechnology Letters, 2014Fusokines are proteins formed by the fusion of two cytokines. They have greater bioavailability and therapeutic potential than individual cytokines or a combination of different cytokines. Interferon-gamma-inducible protein 10 (CXCL10) and lymphotactin (XCL1) are members of the chemotactic family of cytokines, which induce tumor regression by eliciting
Yessica E, Sanchez-Lugo +9 more
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Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice
Biochemical and Biophysical Research Communications, 2010Understanding dendritic cell (DC) subset functions should lead to the development of novel types of vaccine. Here we characterized expression of XC chemokine receptor 1 (XCR1) and its ligand, XCL1. Murine XCR1 was the only chemokine receptor selectively expressed in CD8alpha(+) conventional DCs.
Katsuaki Hoshino +2 more
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Struktur-Funktionsanalyse des Chemokins XCL1
2021Einleitung Chemokine vermitteln die Interaktion von Immunzellen. Das Chemokin XCL1 wird von aktivierten CD8+ T-Zellen und NK-Zellen sezerniert und besitzt die für Chemokine typische Tertiärstruktur, bestehend aus einem N-Terminus, einem antiparallelen β-Faltblatt, einer α Helix und einem freien C-Terminus von etwa 20 Aminosäuren.
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The Chemokines CXCL10 and XCL1 Recruit Human Annulus Fibrosus Cells
Spine, 2012Human annulus fibrosus tissue and cells were analyzed for the presence of chemokine receptors and the migratory effect of selected chemokines.To investigate spontaneous repair mechanisms and underlying cell recruitment in response to annular tears and degenerative defects.Resorption of herniated disc tissue and the attempt to close annulus tears with ...
Aldemar A, Hegewald +7 more
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The chemokine XCL1 functions as a pregnancy hormone to program offspring innate anxiety
Brain, Behavior, and ImmunityElevated levels of cytokines in maternal circulation increase the offspring's risk for neuropsychiatric disease. Because of their low homeostatic levels, circulating maternal cytokines during normal pregnancies have not been considered to play a role in fetal brain development and offspring behavior.
Rosa J. Chen +4 more
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[Biological activity of purificated swine XCL1 protein and preparation of its polyclonal antibody].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2012To obtain purificated his-XCL1 recombinant protein of porcine in vitro and prepare the associated polyclonal antibody; To study how the recombinant protein affects on lymphocytes proliferation.Purify the recombinant protein using HiTrap(TM); Chelating HP chromatographic column; Check the purified product using SDS-PAGE; Detect the expression of the ...
Yao-li, Wu +3 more
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Depressed Levels of XCL1 in Allergic Asthmatic Plasma
Journal of Allergy and Clinical Immunology, 2008S.W. Berquist, K.C. Nadeau
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