Results 61 to 70 of about 9,272 (178)

The NLS3 Motif in TPX2 Regulates Spindle Architecture in Xenopus Egg Extracts

Cytoskeleton, Volume 83, Issue 1, Page 29-39, January 2026.
ABSTRACT A bipolar spindle composed of microtubules and many associated proteins functions to segregate chromosomes during cell division in all eukaryotes, yet both spindle size and architecture vary dramatically across different species and cell types.
Guadalupe E. Pena, Xiao Zhou, Lauren Slevin, Christopher Brownlee, Rebecca Heald   +4 more
wiley   +1 more source

Modeling of Genome-Wide Polyadenylation Signals in Xenopus tropicalis

Frontiers in Genetics, 2019
Alternative polyadenylation (APA) is an important post-transcriptional modification event to process messenger RNA (mRNA) for transcriptional termination, transport, and translation.
Sheng Zhu, Sheng Zhu, Xiaohui Wu, Xiaohui Wu, Xiaohui Wu, Hongjuan Fu, Congting Ye, Congting Ye, Moliang Chen, Zhihua Jiang, Guoli Ji, Guoli Ji, Guoli Ji   +12 more
doaj   +1 more source

Functional Screening of NDUFAF6 Variants in Knockout Cells and Complementary Computational Analysis

Journal of Clinical Laboratory Analysis, Volume 40, Issue 1, January 2026.
We established an ATP‐based functional screening system in NDUFAF6 knockout cells to evaluate the pathogenicity of gene variants associated with mitochondrial dysfunction. Our results highlight the limitations of in silico predictions and underscore the necessity of experimental validation for accurate variant interpretation.
Feng Jiang, Ayumu Sugiura, Yoshihito Kishita, Kohta Nakamura, Xinju Qi, Yuxin Liu, Kei Murayama, Yasushi Okazaki   +7 more
wiley   +1 more source

Exploration of the Pathogenic Mechanism of the Factor XIII A Subunit in a Patient With Congenital Factor XIII Deficiency

Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.
This study identifies a novel Ser414Leu variant in the F13A1 gene associated with congenital FXIII deficiency, demonstrating its potential to destabilize the protein structure. ABSTRACT Background Congenital factor XIII (FXIII) deficiency is an extremely rare autosomal recessive blood clotting disorder with an incidence of approximately one in two ...
Min Wang, Nan Wei, Tianping Chen, Aoshuang Jiang, Yinghui Zhao, Chenglin Zhu, Lijuan Zhu, Lijun Qu, Hongjun Liu   +8 more
wiley   +1 more source

Highly efficient bi-allelic mutation rates using TALENs in Xenopus tropicalis

Biology Open, 2012
Summary In the past decade, Xenopus tropicalis has emerged as a powerful new amphibian genetic model system, which offers all of the experimental advantages of its larger cousin, Xenopus laevis.
Shoko Ishibashi, Rebecca Cliffe, Enrique Amaya   +2 more
doaj   +1 more source

First LDLRAP1 and Recurrent LDLR Mutations in Tunisian Families With Familial Hypercholesterolemia

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Familial hypercholesterolemia (FH) is a genetic disorder characterised by elevated plasma LDL‐cholesterol, predisposing to premature atherosclerotic cardiovascular disease. Most cases follow an autosomal dominant pattern (ADH) caused by pathogenic variants in LDLR, APOB or PCSK9.
Wirath Ben Ncir, Afif Ben‐Mahmoud, Hamdi Frikha, Fatma Abdelhedi, Faten Hadj Kacem, Nabila Majdoub, Mouna Mnif, Hyung‐Goo Kim, Leila Ammar Keskes, Jouke‐Jan Hottenga   +9 more
wiley   +1 more source

Thyroid hormone receptor subtype-specific function in controlling organ-specific developmental timing and rate during Xenopus development

Frontiers in Endocrinology
Thyroid hormone (T3) is essential for vertebrate development as animals fail to develop into adults in the absence of T3. T3 is particularly critical for postembryonic development.
Yuta Tanizaki, Yun-Bo Shi
doaj   +1 more source

Genome-wide identification of Xenopus matrix metalloproteinases: conservation and unique duplications in amphibians

BMC Genomics, 2009
Background Matrix metalloproteinases (MMPs) are members of the superfamily of Zn2+ dependent extracellular or membrane-bound endopeptidases which have been implicated to play critical roles in vertebrate development and human pathogenesis.
Mathew Smita, Das Biswajit, Fu Liezhen, Shi Yun-Bo   +3 more
doaj   +1 more source

Identification of mutants in inbred Xenopus tropicalis

Mechanisms of Development, 2005
Xenopus tropicalis offers the potential for genetic analysis in an amphibian. In order to take advantage of this potential, we have been inbreeding strains of frogs for future mutagenesis. While inbreeding a population of Nigerian frogs, we identified three mutations in the genetic background of this strain.
Grammer, Timothy C., Khokha, Mustafa K., Lane, Maura A., Lam, Kentson, Harland, Richard M.   +4 more
openaire   +2 more sources

Hif1α is required for Wnt regulated gene expression during Xenopus tropicalis tail regeneration [PDF]

, 2021
Jeet H. Patel, Preston A. Schattinger, Evan E. Takayoshi, Andrea E. Wills   +3 more
openalex   +1 more source