Results 81 to 90 of about 10,041 (187)

Geographical Variation in Thermal Adaptation of the Asiatic Toad (Bufo gargarizans)

Integrative Zoology, EarlyView.
Northern and southern populations of Bufo gargarizans exhibit coordinated divergence in thermal preference, resting metabolic rate, and TRPM4 temperature sensitivity along a climatic gradient. ABSTRACT Thermal adaptation in animals can manifest in multiple dimensions, yet few studies have integrated behavioral, physiological, and molecular perspectives
Longcheng Fan, Yonghua Wu
wiley   +1 more source

Rare Biallelic CTU2 Variants in an Individual With CAKUT: Clinical Characterization and Minigene Splicing Analysis

Molecular Genetics &Genomic Medicine, Volume 14, Issue 8, August 2026.
Exome sequencing in 200 CAKUT patients identified compound heterozygous rare CTU2 variants in one renal‐predominant case. Minigene splicing assays showed c.913C>T partially increased exon 9 skipping, supporting further case collection and kidney‐relevant studies to clarify the role of CTU2 in renal developmental phenotypes.
Qian Liu, Xueqin Cheng, Bixia Zheng, Chunli Wang, Wei Zhou, Aihua Zhang   +5 more
wiley   +1 more source

Thyroid hormone receptor subtype-specific function in controlling organ-specific developmental timing and rate during Xenopus development

Frontiers in Endocrinology
Thyroid hormone (T3) is essential for vertebrate development as animals fail to develop into adults in the absence of T3. T3 is particularly critical for postembryonic development.
Yuta Tanizaki, Yun-Bo Shi
doaj   +1 more source

Highly efficient bi-allelic mutation rates using TALENs in Xenopus tropicalis

Biology Open, 2012
Summary In the past decade, Xenopus tropicalis has emerged as a powerful new amphibian genetic model system, which offers all of the experimental advantages of its larger cousin, Xenopus laevis.
Shoko Ishibashi, Rebecca Cliffe, Enrique Amaya   +2 more
doaj   +1 more source

Evolutionary history and recombination in the mitochondrial carrier SLC25 superfamily analyzed by similarities in the exon and transmembrane α‐helix sequences

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Mitochondrial carriers (MCs), which constitute a superfamily also called the solute carrier family 25 (SLC25), are characterized by conserved signature motif sequences and a six‐transmembrane α‐helical transporter domain. They transport a wide variety of substrates ranging from protons, inorganic ions, citric acid cycle intermediates, and ...
Magnus Monné, Daniela Valeria Miniero, Rosa Calvello, Antonia Cianciulli, Luigi Palmieri, Ferdinando Palmieri   +5 more
wiley   +1 more source

Genotyping of CRISPR/Cas9 genome edited Xenopus tropicalis [PDF]

, 2018
The targeted nuclease revolution (ZFN, TALEN, and CRISPR/Cas9) has led to a myriad of reports describing genotyping methodologies for genome edited founders (F0-crispants) and their offspring (F1).
Naert, Thomas, Vleminckx, Kris, Thomas Naert, Kris Vleminckx   +3 more
core   +1 more source

Genome-wide identification of Xenopus matrix metalloproteinases: conservation and unique duplications in amphibians

BMC Genomics, 2009
Background Matrix metalloproteinases (MMPs) are members of the superfamily of Zn2+ dependent extracellular or membrane-bound endopeptidases which have been implicated to play critical roles in vertebrate development and human pathogenesis.
Mathew Smita, Das Biswajit, Fu Liezhen, Shi Yun-Bo   +3 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, Volume 600, Issue 13, Page 1859-1871, July 2026.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Whole tissue imaging of cellular boundaries at sub‐micron resolutions for deep learning cell segmentation: Applications in the analysis of epithelial bending of ectoderm

Developmental Dynamics, Volume 255, Issue 5, Page 503-521, May 2026.
Abstract Background To understand cellular morphology, biologists have relied on traditional optical microscopy of tissues combined with tissue clearing protocols to image structures deep within tissues. Unfortunately, these protocols often struggle to retain cell boundary markers, especially at high enough resolutions necessary for precise cell ...
Sam C. P. Norris, Jimmy K. Hu, Neil H. Shubin   +2 more
wiley   +1 more source

BINge: Multispecies Ortholog Clustering for Differential Gene Expression Analyses

Molecular Ecology Resources, Volume 26, Issue 4, May 2026.
ABSTRACT Differential gene expression (DGE) analysis enables researchers to investigate the link between gene expression and the phenotypic responses observed in organisms across time, experimental, or field conditions. Accurate quantification of gene expression is essential when performing DGE experiments, with a range of methods having been developed
Zachary Stewart, Dimitri Perrin, Alexie Papanicolaou, Peter Prentis   +3 more
wiley   +1 more source