Results 61 to 70 of about 15,671 (201)

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

ADAMTS9, a member of the ADAMTS family, in Xenopus development [PDF]

, 2018
Extracellular matrix (ECM) remodeling by metalloproteinases is crucial during development. The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin type I motifs) enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases ...
Boerboom, Brocker, Brunet, Casini, Dubail, Dupuis, Dutt, Enomoto, Fletcher, Guo, Harrison, Hatch, Jones, Jungers, Kelwick, Kern, Lienkamp, McCulloch, McCulloch, Nandadasa, Nandadasa, Nieuwkoop, Otto, Owens, Rao, Session, Silver, Somerville, Stanton, Suga, Suzuki, Szabo, Tamura, Tomlinson, Tomlinson, Tomlinson, Watanabe, Wheeler   +37 more
core   +1 more source

Whole tissue imaging of cellular boundaries at sub‐micron resolutions for deep learning cell segmentation: Applications in the analysis of epithelial bending of ectoderm

Developmental Dynamics, EarlyView.
Abstract Background To understand cellular morphology, biologists have relied on traditional optical microscopy of tissues combined with tissue clearing protocols to image structures deep within tissues. Unfortunately, these protocols often struggle to retain cell boundary markers, especially at high enough resolutions necessary for precise cell ...
Sam C. P. Norris, Jimmy K. Hu, Neil H. Shubin   +2 more
wiley   +1 more source

An optimized method for cryogenic storage of Xenopus sperm to maximise the effectiveness of research using genetically altered frogs [PDF]

, 2017
© The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Theriogenology 92 (2017): 149–155, doi:10.1016/j.theriogenology.2017.01.007.Cryogenic storage of sperm
Guille, Matthew, Horb, Marko, Lerebours, Adelaide, Morrow, Sean, Noble, Anna, Pearl, Esther   +5 more
core   +2 more sources

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Biallelic variants in COPB1 cause a novel, severe intellectual disability syndrome with cataracts and variable microcephaly

Genome Medicine, 2021
Background Coat protein complex 1 (COPI) is integral in the sorting and retrograde trafficking of proteins and lipids from the Golgi apparatus to the endoplasmic reticulum (ER).
William L. Macken, Annie Godwin, Gabrielle Wheway, Karen Stals, Liliya Nazlamova, Sian Ellard, Ahmed Alfares, Taghrid Aloraini, Lamia AlSubaie, Majid Alfadhel, Sulaiman Alajaji, Htoo A. Wai, Jay Self, Andrew G. L. Douglas, Alexander P. Kao, Matthew Guille, Diana Baralle   +16 more
doaj   +1 more source

The emergence of Pax7-expressing muscle stem cells during vertebrate head muscle development [PDF]

, 2015
Pax7 expressing muscle stem cells accompany all skeletal muscles in the body and in healthy individuals, efficiently repair muscle after injury. Currently, the in vitro manipulation and culture of these cells is still in its infancy, yet muscle stem ...
Anna eNoble, Colin eSharpe, David J. Goldhamer, Erika C. Jorge, Gabrielle eKardon, Julia eMeireles Nogueira, Julia eMeireles Nogueira, Katarzyna eHawrot, Susanne eDietrich, William M. Wood   +9 more
core   +2 more sources

BINge: Multispecies Ortholog Clustering for Differential Gene Expression Analyses

Molecular Ecology Resources, Volume 26, Issue 4, -Not available-.
ABSTRACT Differential gene expression (DGE) analysis enables researchers to investigate the link between gene expression and the phenotypic responses observed in organisms across time, experimental, or field conditions. Accurate quantification of gene expression is essential when performing DGE experiments, with a range of methods having been developed
Zachary Stewart, Dimitri Perrin, Alexie Papanicolaou, Peter Prentis   +3 more
wiley   +1 more source

Metabolomic approach for identifying and visualizing molecular tissue markers in tadpoles of Xenopus tropicalis by mass spectrometry imaging

Biology Open, 2016
In developmental and cell biology it is crucial to evaluate the dynamic profiles of metabolites. An emerging frog model system using Xenopus tropicalis, whose genome sequence and inbred strains are available, is now ready for metabolomics investigation ...
Naoko Goto-Inoue, Akihiko Kashiwagi, Keiko Kashiwagi, Tsukasa Mori   +3 more
doaj   +1 more source

Remobilization of Sleeping Beauty transposons in the germline of Xenopus tropicalis [PDF]

, 2011
Background The Sleeping Beauty (SB) transposon system has been used for germline transgenesis of the diploid frog, Xenopus tropicalis. Injecting one-cell embryos with plasmid DNA harboring an SB transposon substrate together with mRNA encoding the SB ...
Donald A Yergeau, Clair M Kelley, Emin Kuliyev, Haiqing Zhu, Michelle R Johnson Hamlet, Amy K Sater, Dan E Wells, Paul E Mead   +7 more
core   +2 more sources