m6A RNA methylation promotes XIST-mediated transcriptional repression [PDF]
Nature, 2016 The long non-coding RNA X-inactive specific transcript (XIST) mediates the transcriptional silencing of genes on the X chromosome. Here we show that, in human cells, XIST is highly methylated with at least 78 N^6-methyladenosine (m^6A) residues—a ...
Deepak P Patil, Chun-Kan Chen, Amy Chow
exaly +6 more sources
METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST [PDF]
Molecular Cancer, 2020 N6-methyladenosine (m6A) is the most prevalent RNA epigenetic regulation in eukaryotic cells. However, understanding of m6A in colorectal cancer (CRC) is very limited. We designed this study to investigate the role of m6A in CRC.
Xiao Yang, Sen Zhang, Changyu He
exaly +3 more sources
Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing [PDF]
Science, 2016 The Xist long noncoding RNA orchestrates X chromosome inactivation, a process that entails chromosome-wide silencing and remodeling of the three-dimensional (3D) structure of the X chromosome.
Chun-Kan Chen +2 more
exaly +3 more sources
LncRNA Jpx induces Xist expression in mice using both trans and cis mechanisms. [PDF]
PLoS Genetics, 2018 Mammalian X chromosome dosage compensation balances X-linked gene products between sexes and is coordinated by the long noncoding RNA (lncRNA) Xist. Multiple cis and trans-acting factors modulate Xist expression; however, the primary competence factor ...
Sarah Carmona +4 more
doaj +2 more sources
Beyond sequence homology: Cellular biology limits the potential of XIST to act as a miRNA sponge.
PLoS ONE, 2019 IntroductionThe sponging of microRNAs by a long non-coding RNA (lncRNA) away from their coding gene targets is a conceptually-simple, yet biologically-complex method of lncRNA-mediated gene regulation.
Erin A Marshall +4 more
doaj +3 more sources
XIST directly regulates X-linked and autosomal genes in naive human pluripotent cells [PDF]
Cell, Fangyuuan Ding, Kathrin Plath
exaly +2 more sources
Role of Long Non-Coding RNA X-Inactive-Specific Transcript (XIST) in Neuroinflammation and Myelination: Insights from Cerebral Organoids and Implications for Multiple Sclerosis [PDF]
Non-Coding RNABackground/Objectives: X-inactive-specific transcript (XIST) is a factor that plays a role in neuroinflammation. This study investigated the role of XIST in neuronal development, neuroinflammation, myelination, and therapeutic responses within cerebral ...
Nihan Aktas Pepe +4 more
doaj +2 more sources
Transcriptional stochasticity reveals multiple mechanisms of long non-coding RNA regulation at the Xist-Tsix locus. [PDF]
Nat CommunKesler BK, Adams J, Neuert G.
europepmc +3 more sources
Interfering lncRNA XIST inhibits the growth of salivary adenoid cystic carcinoma cells and improves cisplatin sensitivity by up-regulating miR-429 [PDF]
Xin yixue, 2022 ObjectiveTo investigate the regulatory effect and mechanism of lncRNA XIST on salivary adenoid cystic carcinoma （SACC） cell growth and cisplatin （DDP） chemosensitivity.
Zhang Xuan, Ma Licheng, Sun Longxiao, Zhang Lei
doaj +1 more source
Role of lncRNA Xist-miR-124-CCL2 axis in HIV Tat-mediated microglial activation and neuroinflammation. [PDF]
Front ImmunolPeriyasamy P +4 more
europepmc +3 more sources