Results 11 to 20 of about 35,510 (301)

Long non-coding RNA XIST: a novel oncogene in multiple cancers

Molecular Medicine, 2021
Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is an important lncRNA derived from the XIST gene in mammals. XIST is abnormally expressed in numerous tumors, in most of which XIST functions as an oncogene. XIST is involved in multiple
Jun Yang, Manlong Qi, Xiang Fei, Xia Wang, Kefeng Wang   +4 more
doaj   +2 more sources

Knockdown of lncRNA XIST Ameliorates IL-1β-Induced Apoptosis of HUVECs and Change of Tissue Factor Level via miR-103a-3p/HMGB1 Axis in Deep Venous Thrombosis by Regulating the ROS/NF-κB Signaling Pathway

Cardiovascular Therapeutics, 2022
Background. The effect of lncRNA X inactive-specific transcript (XIST) inducing cardiovascular diseases on deep vein thrombosis (DVT) and its mechanism has not been reported.
Guangxin Cao, Hua Zhou, Dong Wang, Lei Xu   +3 more
doaj   +2 more sources

Long noncoding RNA XIST regulates brown preadipocytes differentiation and combats high-fat diet induced obesity by targeting C/EBPα

Molecular Medicine, 2022
Background Activation of brown adipose tissue (BAT) increases energy expenditure, which makes it an attractive therapeutic strategy for obesity. LncRNAs play an important role in adipocyte differentiation and regulation.
Chunyan Wu, Shu Fang, Huijian Zhang, Xiaoqiang Li, Yuejun Du, Yudan Zhang, Xiaochun Lin, Ling Wang, Xiaoqin Ma, Yaoming Xue, Meiping Guan   +10 more
doaj   +2 more sources

XIST and MUC1-C form an auto-regulatory pathway in driving cancer progression

Cell Death and Disease
The long non-coding RNA X-inactive specific transcript (lncRNA XIST) and MUC1 gene are dysregulated in chronic inflammation and cancer; however, there is no known interaction of their functions.
Keyi Wang, Atrayee Bhattacharya, Naoki Haratake, Tatsuaki Daimon, Ayako Nakashoji, Hiroki Ozawa, Bo Peng, Wei Li, Donald Kufe   +8 more
doaj   +2 more sources

XIST/Xist-induced epigenetic events in somatic cells

, 2010
Mammalian dosage compensation of X-linked genes is achieved between XX females and XY males by silencing one of the two X chromosomes. It is the expression of a functional non-coding RNA transcript, XIST that is responsible for the initiation of silencing during X-chromosome inactivation. XIST expression and subsequent in cis localization to the future
Nancy P. Thorogood
openalex   +2 more sources

LncRNA XIST promotes bladder cancer progression by modulating miR-129-5p/TNFSF10 axis

Discover Oncology
Background The differential expression, biological function, and ceRNA regulatory mechanism of lncRNA XIST in bladder cancer (BC) were investigated, and its clinical values for the early diagnosis of bladder cancer patients were elucidated.
Yu-Lin Kong, Hui-Dan Wang, Meng Gao, Sheng-Zhong Rong, Xiao-Xia Li   +4 more
doaj   +2 more sources

LncRNA XIST regulates breast cancer stem cells by activating proinflammatory IL-6/STAT3 signaling [PDF]

Oncogene, 2023
Aberrant expression of XIST, a long noncoding RNA (lncRNA) initiating X chromosome inactivation (XCI) in early embryogenesis, is a common feature of breast cancer (BC). However, the roles of post-XCI XIST in breast carcinogenesis remain elusive.
Yuxi Ma, Yongyou Zhu, Shang Li, Yan Qiu, Na Shen, Jonathan Wang, Tiffany Adam, Wei Wei, Qingxuan Song, Jun Li, Max S. Wicha, Ming Luo   +11 more
openalex   +2 more sources

The X Factor in Immunity: Sex Differences Shaped by the X Chromosome. [PDF]

Immunol Rev
ABSTRACT There are sex differences with immune responses where females exhibit stronger immune responses compared to males. Both sex hormones and sex chromosome differences between males and females contribute to the observed sex differences with innate and adaptive immune cell composition and function.
Radovanovic KB, Wynalda M, Anguera MC.
europepmc   +2 more sources

Sex Matters: Hormonal and Chromosomal Determinants of Autoimmunity and Anti-Cancer Immunity Across the Lifespan. [PDF]

Immunol Rev
ABSTRACT Sex plays a key role in shaping both anti‐cancer immunity and autoimmunity. Biological factors underlying sexual dimorphism have now been identified in multiple aspects of anti‐cancer immunity and autoimmunity. These factors include sex differences in hormone levels, chromosome complement, and expression of the long non‐coding RNA XIST.
Bustillos CG, Peluso EM, Cha SL, Lechner MG, Su MA.   +4 more
europepmc   +2 more sources

XIST in Brain Cancer [PDF]

Clinica Chimica Acta, 2022
Long non-coding RNAs (lncRNAs) make up the majority of the human genome. They are a group of small RNA molecules that do not code for any proteins but play a primary role in regulating a variety of physiological and pathological processes. X-inactive specific transcript (XIST), one of the first lncRNAs to be discovered, is chiefly responsible for X ...
Eldesouki, Salma, Samara, Kamel A, Qadri, Rama, Obaideen, Anas A, Otour, Ahmad H, Habbal, Omar, Ahmed, Samrein   +6 more
openaire   +2 more sources