Results 21 to 30 of about 35,510 (301)
Xist ribonucleoproteins promote female sex-biased autoimmunity
Cell, 2023 Autoimmune diseases disproportionately affect females more than males. The XX sex chromosome complement is strongly associated with susceptibility to autoimmunity.
Diana R. Dou +23 more
semanticscholar +1 more source
Maintenance of Xist Imprinting Depends on Chromatin Condensation State and Rnf12 Dosage in Mice. [PDF]
PLoS Genetics, 2016 In female mammals, activation of Xist (X-inactive specific transcript) is essential for establishment of X chromosome inactivation. During early embryonic development in mice, paternal Xist is preferentially expressed whereas maternal Xist (Xm-Xist) is ...
Atsushi Fukuda +5 more
doaj +1 more source
Xist Exon 7 Contributes to the Stable Localization of Xist RNA on the Inactive X-Chromosome. [PDF]
PLoS Genetics, 2015 To equalize X-linked gene dosage between the sexes in mammalian females, Xist RNA inactivates one of the two X-chromosomes. Here, we report the crucial function of Xist exon 7 in X-inactivation.
Norishige Yamada +5 more
doaj +1 more source
Exploring the Role of Long Noncoding RNAs in Breast Cancer Progression: A Comprehensive Study on Biomarkers and Therapeutic Approaches. [PDF]
Cancer MedABSTRACT Background Among the many forms of cancer that plague women all over the globe, breast cancer (BC) is one of the most prevalent kinds. BC is a multifaceted disease that can manifest in many ways depending on the individual. Aims The identification of new biomarkers that may be used to diagnose and prognosis of the BC, as well as those that can
Moeini R, AhsanAlkhat A, Ghorbian S.
europepmc +2 more sources
Proceedings of the 2nd workshop on NLP and XML - NLPXML '02, 2002 This paper describes the use of XML in three generic interacting speech technology systems. The first, a phonological syllable recognition system, generates feature-based finite-state automaton representations of phonotactic constraints in XML. It employs axioms of event logic to interpret multilinear representations of speech utterances and outputs ...
Michael Walsh +2 more
openaire +1 more source
Biological Function of Long Non-coding RNA (LncRNA) Xist
Frontiers in Cell and Developmental Biology, 2021 Long non-coding RNAs (lncRNAs) regulate gene expression in a variety of ways at epigenetic, chromatin remodeling, transcriptional, and translational levels. Accumulating evidence suggests that lncRNA X-inactive specific transcript (lncRNA Xist) serves as
Wenlun Wang +7 more
semanticscholar +1 more source
Wellcome Open Research, 2020 Background: X chromosome inactivation in mammals is regulated by the non-coding (nc) RNA, Xist, which represses the chromosome from which it is transcribed.
Heather Coker +5 more
doaj +1 more source
The XIST lncRNA is a sex-specific reservoir of TLR7 ligands in SLE
JCI Insight, 2023 Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with a dramatic sex bias, affecting 9 times more women than men. Activation of Toll-like receptor 7 (TLR7) by self-RNA is a central pathogenic process leading to aberrant production of ...
Jonathan D. Crawford +14 more
semanticscholar +1 more source
B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells
Cell, 2021 The long noncoding RNA (lncRNA) XIST establishes X chromosome inactivation (XCI) in female cells in early development and thereafter is thought to be largely dispensable.
Bingfei Yu +5 more
semanticscholar +2 more sources
F1000Research, 2020 Female mammals express the long noncoding X inactivation-specific transcript (Xist) RNA to initiate X chromosome inactivation (XCI) that eventually results in the formation of the Barr body. Xist encompasses half a dozen repeated sequence stretches containing motifs for RNA-binding proteins that recruit effector complexes with functions for silencing ...
Asun Monfort, Anton Wutz
openaire +3 more sources