Results 31 to 40 of about 35,510 (301)

Species-specific regulation of XIST by the JPX/FTX orthologs

Nucleic Acids Research, 2023
X chromosome inactivation (XCI) is an essential process, yet it initiates with remarkable diversity in various mammalian species. XIST, the main trigger of XCI, is controlled in the mouse by an interplay of lncRNA genes (LRGs), some of which evolved ...
Olga Rosspopoff, Emmanuel Cazottes, Christophe Huret, Agnese Loda, A. Collier, Miguel Casanova, P. Rugg-Gunn, E. Heard, Jean-François Ouimette, C. Rougeulle   +9 more
semanticscholar   +1 more source

XIST dampens X chromosome activity in a SPEN-dependent manner during early human development

bioRxiv, 2023
XIST long non-coding RNA is responsible for X chromosome inactivation (XCI) in placental mammals, yet it accumulates on both X chromosomes in human female pre-implantation embryos without triggering X chromosome silencing. The long non-coding RNA XACT co-
Charbel Alfeghaly, G. Castel, Emmanuel Cazottes, Madeleine Moscatelli, Eva Moinard, Miguel Casanova, Juliette Boni, Kasturi Mahadik, Jenna Lammers, T. Fréour, L. Chauvière, Carla Piqueras, R. Boers, J. Boers, J. Gribnau, L. David, Jean-François Ouimette, C. Rougeulle   +17 more
semanticscholar   +1 more source

XIST promotes cell proliferation and invasion by regulating miR-140-5p and SOX4 in retinoblastoma

World Journal of Surgical Oncology, 2020
Background Retinoblastoma (RB) is the most common intraocular malignancy in children. Long non-coding RNA X-inactive specific transcript (lncRNA XIST) has been reported to be associated with RB, but research on the mechanism of XIST is not well studied ...
Yuhui Wang, Dahong Sun, Ying Sheng, Hong Guo, Fanchun Meng, Tingting Song   +5 more
doaj   +1 more source

Long noncoding RNA XIST knockdown relieves the injury of microglia cells after spinal cord injury by sponging miR-219-5p

Open Medicine, 2021
Long noncoding RNAs have been demonstrated to play crucial roles in the pathogenesis of spinal cord injury (SCI). In this study, we aimed to explore the roles and underlying mechanisms of lncRNA X-inactive specific transcript (XIST) in SCI progression ...
Zhong Xueren, Bao Yongzheng, Wu Qiang, Xi Xinhua, Zhu Wengang, Chen Sanmei, Liao Junjian   +6 more
doaj   +1 more source

Illuminating Xist [PDF]

The Biochemist, 2015
The Central Dogma proposed that RNA, encoded by DNA in the genome, acts as the template used by cells for protein production. The simplicity of RNA as a discrete mediator of information has subsequently been challenged by the discovery of non-protein-coding RNAs.
Heather Coker, Benoit Moindrot, Greta Pintacuda, Neil Brockdorff   +3 more
openaire   +1 more source

Artemisinin suppresses aerobic glycolysis in thyroid cancer cells by downregulating HIF-1a, which is increased by the XIST/miR-93/HIF-1a pathway

PLoS ONE, 2023
The incidence of thyroid cancer (TC) continues to increase worldwide. Aerobic glycolysis, the prominent feature of glucose metabolism in cancer progression, is associated with TC. We first demonstrated that HIF-1a is highly expressed in TC tissues and is
Fei Yang, J Zhang, Zhijun Zhao, Yan Liu, Zhen Zhao, K. Fu, Baokun Li, J. Jin   +7 more
semanticscholar   +1 more source

Long non‐coding RNA XIST expedites lung adenocarcinoma progression through upregulating MDM2 expression via binding to miR‐363‐3p

Thoracic Cancer, 2020
Background Lung adenocarcinoma (LAD) is a highly aggressive malignant tumor which threatens the health and life of the population. Long non‐coding RNA X‐inactive specific transcript (XIST) and mouse double minute clone 2 (MDM2) are connected with the ...
Hao Rong, Bing Chen, Xing Wei, Jun Peng, Ke Ma, Song Duan, Jintao He   +6 more
doaj   +1 more source

Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation

eLife, 2020
The Xist lncRNA mediates X chromosome inactivation (XCI). Here we show that Spen, an Xist-binding repressor protein essential for XCI , binds to ancient retroviral RNA, performing a surveillance role to recruit chromatin silencing machinery to these ...
Ava C Carter, Jin Xu, Meagan Y Nakamoto, Yuning Wei, Brian J Zarnegar, Quanming Shi, James P Broughton, Ryan C Ransom, Ankit Salhotra, Surya D Nagaraja, Rui Li, Diana R Dou, Kathryn E Yost, Seung-Woo Cho, Anil Mistry, Michael T Longaker, Paul A Khavari, Robert T Batey, Deborah S Wuttke, Howard Y Chang   +19 more
doaj   +1 more source

Gender dimorphism in hepatocarcinogenesis—DNA methylation modification regulated X‐chromosome inactivation escape molecule XIST

Clinical and Translational Medicine, 2023
Background Sex disparities constitute a significant issue in hepatocellular carcinoma (HCC). However, the mechanism of gender dimorphism in HCC is still not completely understood.
Zhihui Dai, Sijie Wang, Xinggang Guo, Yuefan Wang, Haozan Yin, Jian Tan, Chenyang Mu, Shu‐Han Sun, Hui Liu, Fu Yang   +9 more
doaj   +1 more source

Emodin Regulates lncRNA XIST/miR-217 Axis to Protect Myocardial Ischemia-Reperfusion Injury

Oxidative Medicine and Cellular Longevity, 2023
Purpose This study is aimed at investigating the effect of emodin on myocardial ischemia-reperfusion injury (MIRI) and mechanism. Methods Eighty healthy adult male SD rats (weighing 230-250 g) were utilized to establish I/R model, which were randomly ...
Shuai Huang, Lailiang Xue, Qiaona Mou
semanticscholar   +1 more source