Results 41 to 50 of about 35,510 (301)
High-resolution Xist binding maps reveal 2-step spreading during X-inactivation [PDF]
, 2014 The Xist long noncoding RNA (lncRNA) is essential for X-chromosome inactivation (XCI), the process by which mammals compensate for unequal numbers of sex chromosomes1-3.
Bowman, Sarah K. +9 more
core +1 more source
Nature Cell Biology, 2023 Through a CRISPR-activation screen, Ravid Lustig et al. show that GATA transcription factors activate long-range Xist enhancers to upregulate Xist expression and initiate X chromosome inactivation in early mouse embryos.
Liat Ravid Lustig +13 more
semanticscholar +1 more source
A regulatory potential of the Xist gene promoter in vole M. rossiaemeridionalis. [PDF]
PLoS ONE, 2012 X chromosome inactivation takes place in the early development of female mammals and depends on the Xist gene expression. The mechanisms of Xist expression regulation have not been well understood so far. In this work, we compared Xist promoter region of
Konstantin E Orishchenko +7 more
doaj +1 more source
Linking Chromosomal Silencing With Xist Expression From Autosomal Integrated Transgenes
Frontiers in Cell and Developmental Biology, 2021 Xist is the master regulator of X-Chromosome Inactivation (XCI), the mammalian dosage compensation mechanism that silences one of the two X chromosomes in a female cell. XCI is established during early embryonic development.
Ikrame Naciri +7 more
doaj +1 more source
The role of maternal-specific H3K9me3 modification in establishing imprinted X-chromosome inactivation and embryogenesis in mice [PDF]
, 2015 Maintaining a single active X-chromosome by repressing Xist is crucial for embryonic development in mice. Although the Xist activator RNF12/RLIM is present as a maternal factor, maternal Xist (Xm-Xist) is repressed during preimplantation phases to ...
Akutsu, Hidenori +7 more
core +1 more source
Scientific Reports, 2023 Anti-phospholipid syndrome (APS) is an autoimmune disease characterized by thrombosis and miscarriage events. Still, the molecular mechanisms underlying APS, which predisposes to a wide spectrum of complications, are being explored. Seventy patients with
Mai A. Abd-Elmawla +2 more
semanticscholar +1 more source
Regenerative Therapy, 2022 Introduction: The functional roles and mechanism of the XIST in osteoarthritis and the chondrogenic differentiation of BMSCs were clarified. Methods: The expression levels of XIST, TAF15, FUT1 and YY1 were detected through quantitative RT-PCR.
Jian-Ying He +7 more
doaj +1 more source
Self-assembly and DNA binding of the blocking factor in X chromosome inactivation [PDF]
, 2007 X chromosome inactivation (XCI) is the phenomenon occurring in female mammals whereby dosage compensation of X-linked genes is obtained by transcriptional silencing of one of their two X chromosomes, randomly chosen during early embryo development. The
Antonella Prisco +2 more
core +3 more sources
The Challenges and Opportunities of lncRNAs in Ovarian Cancer Research and Clinical Use [PDF]
, 2020 [Abstract] Ovarian cancer is one of the most lethal gynecological malignancies worldwide because it tends to be detected late, when the disease has already spread, and prognosis is poor.
Barreiro-Alonso, Aida +6 more
core +1 more source
Experimental and Therapeutic Medicine, 2023 Centromere coiled-coil protein 110 (CCP110) plays a role in the development of several types of cancer; however, its regulatory mechanism and role in endometrial cancer is unclear.
Shu Chen +3 more
semanticscholar +1 more source