Results 51 to 60 of about 35,510 (301)

The Mbd1-Atf7ip-Setdb1 pathway contributes to the maintenance of X chromosome inactivation. [PDF]

, 2014
BackgroundX chromosome inactivation (XCI) is a developmental program of heterochromatin formation that initiates during early female mammalian embryonic development and is maintained through a lifetime of cell divisions in somatic cells.
Bonora, Giancarlo, Minkovsky, Alissa, Patel, Sanjeet, Plath, Kathrin, Rankin-Gee, Elyse, Sahakyan, Anna   +5 more
core   +3 more sources

Inhibition of long non-coding RNA XIST upregulates microRNA-149-3p to repress ovarian cancer cell progression

Cell Death and Disease, 2021
Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) play critical roles in human diseases. We aimed to clarify the role of lncRNA X-inactive specific transcript (XIST)/miR-149-3p/forkhead box P3 (FOXP3) axis in ovarian cancer (OC) cell growth.
Rong Jiang, Hongyu Zhang, Jinhua Zhou, Juan Wang, Yuejuan Xu, He Zhang, Yanzheng Gu, Fengqing Fu, Yu Shen, Guangbo Zhang, Lanlan Feng, Xueguang Zhang, Youguo Chen, Fangrong Shen   +13 more
doaj   +1 more source

Dosage Sensing, Threshold Responses, and Epigenetic Memory: A Systems Biology Perspective on Random X‐Chromosome Inactivation

, 2020
X‐chromosome inactivation ensures dosage compensation between the sexes in mammals by randomly choosing one out of the two X chromosomes in females for inactivation.
Barr M. L., Comings D. E., Delbrück M., Rastan S., Rosspopoff O.   +4 more
core   +1 more source

Xist and Tsix transcription dynamics is regulated by the X-to-autosome ratio and semistable transcriptional states [PDF]

, 2016
In female mammals, X chromosome inactivation (XCI) is a key process in the control of gene dosage compensation between Xlinked genes and autosomes.
Berge, D. (Derk) ten, Gribnau, J.H. (Joost), Grootegoed, J.A. (Anton), Kremers, G.J. (Gert-Jan), Lehmann, J. (Johannes), Loda, A. (Agnese), Loos, F. (Friedemann), Maduro, C.M. (Cheryl)   +7 more
core   +1 more source

Extinction of Xist Improves Cloning [PDF]

Cell Stem Cell, 2010
Mammalian cloning by somatic cell nuclear transfer is a notoriously inefficient process with a low birth rate. Recently in Science, Inoue et al. (2010) report that somatic cell nuclear transfer fails to regulate Xist expression from the X chromosome.
Tonge, Peter Dennis, Nagy, Andras
openaire   +2 more sources

LncRNA XIST facilitates the odontogenic differentiation of dental pulp stem cells via the FUS/ZBTB16 [PDF]

Journal of Applied Oral Science
Objective This study aims to explore the regulatory mechanism of long noncoding RNA X inactive specific transcript (lncRNA XIST) in the odontogenic differentiation of human dental pulp stem cells (hDPSCs).
Ruiqing CHENG, Honglei SUN, Xiaotong QIAO, Xuefang CHEN   +3 more
doaj   +1 more source

Stability of XIST repression in relation to genomic imprinting following global genome demethylation in a human cell line [PDF]

, 2014
DNA methylation is essential in X chromosome inactivation and genomic imprinting, maintaining repression of XIST in the active X chromosome and monoallelic repression of imprinted genes.
Araújo, E.S.S. de, Carramaschi, Lygia da Veiga Pereira, Krepischi, Ana Cristina Victorino, Stabellini, R., Vasques, L.R.   +4 more
core   +3 more sources

LncRNA XIST promoted the stability of TLR9 mRNA in a FUS-dependent manner to facilitate aerobic glycolysis and proliferation in Th17/CD4+T cells

Linchuang shenzangbing zazhi, 2022
ObjectiveTo explore the expression and function of lncRNA XIST in Th17 cells in IgA nephropathy （IgAN） and examine the regulation of lncRNA XIST on TLR9 mRNA expression.MethodsCD4+T cells were isolated from peripheral blood mononuclear cells （PBMCs） and ...
Wu Yan-ping, Ma Xiao, Han Si-ping, Wang Xiao-qin   +3 more
doaj  

lncRNA XIST inhibition promotes M2 polarization of microglial and aggravates the spinal cord injury via regulating miR-124–3p / IRF1 axis

Heliyon, 2023
Background: Spinal cord injury (SCI) has a high disability rate and mortality rate. Recently, LncRNA XIST has been found to be involved in the regulation of inflammatory responses. Therefore, we aimed to investigate the role of XIST in the occurrence and
Jin Yang, Zhiqiang Gong, Junjie Dong, Hangchuan Bi, Bing Wang, Kaili Du, Chunqiang Zhang, Lingqiang Chen   +7 more
doaj   +1 more source

Identification and functional analysis of LncRNA-XIST ceRNA network in prostate cancer

BMC Cancer, 2022
Background Long non-coding RNAs (lncRNAs) play a functional role in the progression of prostate cancer (PCa). However, the molecular mechanism, expression, or function of the lncRNA XIST in PCa is not well understood.
Jie Wang, Jie Huang, Yingxue Guo, Yuli Fu, Yifang Cao, Kang Zhou, Jianxiong Ma, Bodong Lv, Wenjie Huang   +8 more
doaj   +1 more source