Results 61 to 70 of about 35,510 (301)
Regulation of X-linked gene expression during early mouse development by [PDF]
, 2016 Mammalian X-linked gene expression is highly regulated as female cells contain two and male one X chromosome (X). To adjust the X gene dosage between genders, female mouse preimplantation embryos undergo an imprinted form of X chromosome inactivation ...
Bach, Ingolf +13 more
core +4 more sources
Xist regulation and function eXplored [PDF]
Human Genetics, 2011 X chromosome inactivation (XCI) is a process in mammals that ensures equal transcript levels between males and females by genetic inactivation of one of the two X chromosomes in females. Central to XCI is the long non-coding RNA Xist, which is highly and specifically expressed from the inactive X chromosome.
Pontier DB, Gribnau J
openaire +2 more sources
Journal of International Medical Research, 2021 Objective To evaluate the predictive value of long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) for survival, and determine the involvement of miRNA(miR)-200b-3p and zinc finger E-box-binding homeobox (ZEB) 1/2 in the pro-tumor effect of
Lili Liu +3 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2017 Backgrounds/Aims: Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is involved in the progression of several tumors. The interaction between lncRNA and miRNA or miRNA’s target genes is reported to play crucial roles in malignancy.
Yaoyao Xiong +5 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 The present study was directed toward laying new findings for Extranodal natural killer/T-cell lymphoma (ENKL)-oriented therapy with a focus on long non-coding RNA (lncRNA)–microRNAs (miRNAs)–mRNA interaction.
Qinhua Liu +6 more
doaj +1 more source
Rheumatology & Autoimmunity, 2022 Background Systemic lupus erythematosus (SLE) is a particularly heterogeneous autoimmune disease. This study was intended to clarify the correlations between X‐inactive‐specific transcript (XIST) expression and SLE clinical features and the contribution ...
Qi Cheng +6 more
doaj +1 more source
Systematic optimization of human pluripotent stem cells media using Design of Experiments. [PDF]
, 2015 Human pluripotent stem cells (hPSC) are used to study the early stages of human development in vitro and, increasingly due to somatic cell reprogramming, cellular and molecular mechanisms of disease.
Chailangkarn, Thanathom +2 more
core +1 more source
Activation of Xist by an evolutionarily conserved function of KDM5C demethylase
Nature Communications, 2022 XX female and XY male therian mammals equalize X-linked gene expression through the mitotically-stable transcriptional inactivation of one of the two X chromosomes in female somatic cells.
M. Samanta +11 more
semanticscholar +1 more source
Unleashing XIST from X-chromosome inactivation
Current Opinion in Cell BiologyRecognition that the most abundant class of genes present in the human genome are those producing long noncoding RNA (lncRNA) has hyped research on this category of transcripts. One such prototypical RNA, Xist, has particularly fueled interest. Initially characterized for its specific expression from the inactive X (Xi), recent studies have uncovered ...
Céline Morey +2 more
openalex +3 more sources
Journal of Cellular and Molecular Medicine, 2021 Exosomal lncRNAs secreted by cancer cells can serve as potential biomarkers in the diagnosis and prognosis of various tumours. Here, we are committed to explore the diagnostic and prognostic value of serum exosomal XIST secreted by tumour cells to ...
Fengming Lan +4 more
semanticscholar +1 more source