Results 111 to 120 of about 31,444 (137)

TNFAIP3 Interacting Protein 3 Is an Activator of Hippo‐YAP Signaling Protecting Against Hepatic Ischemia/Reperfusion Injury

Hepatology, 2021
Background and Aims Hepatic ischemia/reperfusion (I/R) injury, a common clinical problem that occurs during liver surgical procedures, causes a large proportion of early graft failure and organ rejection cases. The identification of key regulators of hepatic I/R injury may provide potential strategies to clinically improve the ...
Junjie Zhou, Manli Hu, Meiling He, Xiaoming Wang, Dating Sun, Yongping Huang, Xu Cheng, Jiajun Fu, Jie Cai, Tengfei Ma, Song Tian, Yufeng Hu, Fengjiao Hu, Dan Liu, Yanqi He, Lanlan Yan, Zhi‐Gang She, Xiao‐Jing Zhang, Yan‐Xiao Ji, Hui Liu, Hongliang Li, Hailong Yang, Peng Zhang   +22 more
openaire   +2 more sources

Abstract 919: Intercalated Disk Protein Xin-beta is Required for the Hippo/YAP Signaling in the Heart

Circulation Research, 2019
Cardiovascular diseases continue to be a leading cause of death and disability. Despite this alarming fact, there is lack of effectual treatment and the molecular mechanisms underlying these devastating diseases remain elusive. Intercalated disk (ICD) is not only essential for the integrity of cardiomyocytes to withstand the strong mechanical forces ...
Haipeng Guo, Yao Wei Lu, Zhiqiang Lin, Zhanpeng Huang, Jianming Liu, Xiaoyun Hu, Yi Wang, Tiago Fernandes, Yuxuan Guo, Jenny L.-C Lin, Jim J.-C Lin, Francisco Naya, William T Pu, Da-Zhi Wang   +13 more
openaire   +1 more source

Abstract 17308: Effect of HIV Protein-Tat & Cocaine on Hippo-YAP Signaling Axis in Pulmonary Arterial Smooth Muscle Cells

Circulation, 2018
Introduction and hypothesis: Intravenous drug use (IVDU) is considered to be one of the important risk factors in the development of HIV-associated pulmonary arterial hypertension (HPAH). Our previous findings demonstrate that the exposure of cocaine to HIV infected individuals has an additive effect in enhancing the ...
Aradhana Mohan, Himanshu Sharma, Mahendran Chinnappan, Navneet K Dhillon   +3 more
openaire   +1 more source

Deficiency of vitamin D-binding protein exacerbates liver fibrosis by disrupting iron homeostasis via the activation of YAP signaling

Experimental Cell Research
Liver fibrosis is a chronic progressive disease that can advance to cirrhosis or hepatocellular carcinoma if untreated. While liver transplantation remains the only curative option for end-stage fibrosis, the development of alternative therapies is urgently needed.
Qing, Zheng, Qingquan, Tan, Dan, Wang, Yanling, Ma, Yanni, Zhou, Yonghua, Chen, Dan, Long, Jiayin, Yang, Li, Feng   +8 more
openaire   +2 more sources

Zinc finger protein 367 exerts a cancer-promoting role in small cell lung cancer by influencing the CIT/LATS2/YAP signaling cascade

Toxicology and Applied Pharmacology
A remarkable cancer-related role of zinc finger protein 367 (ZNF367) has been demonstrated in multiple malignancies. However, whether ZNF367 has a role in small-cell lung cancer (SCLC) remains unexplored. The purpose of this work was to explore the potential role and mechanism of ZNF367 in SCLC. In silico analysis using the Gene Expression Omnibus (GEO)
Ranran, Kong, Yuefeng, Ma, Wendeng, Li, Zhengshui, Xu, Songyu, Gong, Aoran, Liu, Chuantao, Cheng, Xinwu, Zhang, Jie, Qin, Shaomin, Li, Jie, Feng, Jiantao, Jiang   +11 more
openaire   +2 more sources

P-657 Inhibition of insulin-like growth factor binding protein 4 in granulosa cells extends female fertility age via activation of YAP signaling

Human Reproduction
Abstract Study question What role does IGFBP4 play in granulosa cells (GCs) function and ovarian aging, and can targeting IGFBP4 enhance female fertility? Summary answer IGFBP4 inhibits GCs proliferation via YAP signaling.
W Li, Q Hu, F Guo, A Geng, Y A Zeng
openaire   +1 more source

Multi-Functional Regulation by YAP/TAZ Signaling Networks in Tumor Progression and Metastasis

Cancers, 2023
Hannah Thrash, Ann Marie Pendergast, Pendergast Ann Marie   +2 more
exaly  

An overview of signaling pathways regulating YAP/TAZ activity

Cellular and Molecular Life Sciences, 2020
Boon Chin Heng, Xuehui Zhang, Yunyang Bai   +2 more
exaly