Results 191 to 200 of about 60,617 (307)

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

The HIPPO pathway in gynecological malignancies

, 2020
Dong, J., He, J., Meyer, T., Wang, D., Xu, T.   +4 more
core  

Ginsenoside Rg1 ameliorates lipopolysaccharide-induced depressive-like behaviors in mice by attenuating neuroinflammation and neuronal damage. [PDF]

Sci Rep
Zhang L, Tang J, Fang Z, Wang G, Wang N, Chen H, Pei L.   +6 more
europepmc   +1 more source

Decoding epilepsy's molecular blueprint: Machine learning unravels transcriptomic subtypes and regulatory networks

Epilepsia, EarlyView.
Abstract Objective Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy. The molecular heterogeneity underlying DRE remains poorly defined, largely due to limited access to resected brain tissue and substantial genetic diversity.
Yanping Weng, Yu Ma, Wanwan Hou, Haibo Li, Yuanfeng Zhou, Rui Zhao, Hao Li, Lian Chen, Yangyang Ma, Li Jin, Yi Wang, Yu An   +11 more
wiley   +1 more source

Effects of SCH23390 on mRNA and protein expression of factors in the YAP-TGF-β-Smad signaling pathway in ARPE-19 cells.

Jing Fan (149601), Qiujin Zhang (472724), Liu Zheng (1880860), Binbin Yang (2259313), He Jin (12261804), Tingyu Meng (22560141), Zhixiang Ding (15349443)   +6 more
openalex   +2 more sources

O-GlcNAcylation of IGF2BP2 promotes angiogenesis after ischemic stroke by stabilizing PPP2CA in an m6A-dependent manner : O-GlcNAcylation of IGF2BP2 alleviates ischemic brain injury. [PDF]

J Transl Med
Sun S, Chen X, Deng Y, Tao M, Zhu Y.
europepmc   +1 more source

The signaling protein Wnt5a promotes TGFβ1-mediated macrophage polarization and kidney fibrosis by inducing the transcriptional regulators Yap/Taz [PDF]

, 2018
Feng Ye, Yan Liang, Xingwen Zhu, Mingjie Wang, Yuan Gui, Qingmiao Lu, Mengru Gu, Xian Xue, Xiaoli Sun, Weichun He, Junwei Yang, Randy L. Johnson, Chunsun Dai   +12 more
openalex   +1 more source

The WNK-OXSR1 osmosensing pathway mediates intestinal regeneration via Hippo-YAP signaling. [PDF]

EMBO J
Cao H, Huang X, Jiang X, Deng J, Wang J, Wu C, Hu M, Zeng B, Hu Z, Pan H, Yang Y, Zheng K, Shen R, Zhang M, Liu B.   +14 more
europepmc   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

PRIP/PLCL deficiency activates PI3K-AKT-YAP signaling and promotes organ fibrosis. [PDF]

Cell Commun Signal
Yuan M, Sano T, Gao J, Mizokami A, Kanematsu T.   +4 more
europepmc   +1 more source