Results 201 to 210 of about 60,617 (307)

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Targeting Hippo-YAP/TAZ signaling pathway: an updated review demonstrating the therapeutic potential of key plant derived anticancer compounds. [PDF]

Front Pharmacol
Elsori D, Pandey P, Alshaikh K, Alkhathami AG, Saeed M, Singh A, Khan F.   +6 more
europepmc   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling [PDF]

Fa‐Xing Yu, Bin Zhao, Nattapon Panupinthu, Jenna L. Jewell, Ian Lian, Lloyd H. Wang, Jiagang Zhao, Hai‐Xin Yuan, Karen Tumaneng, Hairi Li, Xiangdong Fu, Gordon B. Mills, Kun‐Liang Guan   +12 more
openalex   +1 more source

The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling [PDF]

, 2015
Costanza Giampietro, Andrea Disanza, Luca Bravi, Miriam Barrios‐Rodiles, Monica Corada, Emanuela Frittoli, Cecilia Savorani, Maria Grazia Lampugnani, Barbara Boggetti, Carien M. Niessen, Jeffrey L. Wrana, Giorgio Scita, Elisabetta Dejana   +12 more
openalex   +1 more source

Zinc Finger E‐Box Binding Homeobox 1 Mediates Alcohol‐Induced Liver Disease

iNew Medicine, EarlyView.
Alcohol intake leads to the upregulation of ZEB1, which activates the YAP‐IL‐1β/MCP‐1 pathway, resulting in the activation of liver inflammation and the induction of hepatocyte apoptosis. ABSTRACT Hepatitis resulting from alcoholic liver disease (ALD) is an important risk factor for liver cancer. It is essential to understand the role of ALD to prevent
Boyu Zhang, Chunyang Zhang, Xiao Cui, Tao Xu, Xiangpeng Hu, Jiong Gu   +5 more
wiley   +1 more source

Cardiac mechanotransduction from development to disease. [PDF]

APL Bioeng
Kim NY, Jo H, Becker C, Soicher I, Ni Y, Cho S, Kim H.   +6 more
europepmc   +1 more source

β1 integrin–dependent Rac/group I PAK signaling mediates YAP activation of Yes-associated protein 1 (YAP1) via NF2/merlin [PDF]

, 2017
Hiba Sabra, Molly Brunner, Vinay Mandati, Bernhard Wehrle‐Haller, Dominique Lallemand, Anne‐Sophie Ribba, Geneviève Chevalier, Philippe Guardiola, Marc R. Block, Daniel Bouvard   +9 more
openalex   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Essential Role of Integrin-Linked Kinase in Keratinocyte Responses to Mechanical Strain. [PDF]

Int J Mol Sci
Rudkouskaya A, Ivanova IA, Sayedyahossein S, Dagnino L.   +3 more
europepmc   +1 more source