YBX1: an RNA/DNA-binding protein that affects disease progression [PDF]
Frontiers in OncologyYBX1 is a member of the Y-box transcription factor family and is a multifunctional RNA/DNA-binding protein characterized by a highly conserved cold shock domain (CSD).
Xifeng Zheng +8 more
doaj +4 more sources
YBX1 promotes angiogenesis after myocardial infarction by stabilizing HIF1α mRNA via m6A signaling [PDF]
iScienceSummary: Angiogenesis is essential for myocardial repair after myocardial infarction (MI). While Y-box binding protein 1 (YBX1) is well-established in cancer biology, its role in post-MI angiogenesis remains unknown. Here, we show that YBX1 expression is
Fangfang Bi +13 more
doaj +2 more sources
YBX1 orchestrates LDHA-mediated metabolic reprogramming and NF-κB activation to drive clear cell renal cell carcinoma progression [PDF]
Cell Death and DiseaseRenal cell carcinoma (RCC) is sometimes referred to as a “metabolic disease”, as nearly all types of RCC are associated with the reprogramming of glucose and lipid metabolism.
Yihan Dong +10 more
doaj +2 more sources
CircEPHB4 binds to YBX1 to upregulate MRPS16 and promotes glioma progression [PDF]
Cellular and Molecular Life SciencesBackground Glioma is the most frequently diagnosed brain tumor in adults worldwide which is associated with unfavorable prognosis and survival time. However, the understanding of glioma progression remains limited.
Yuxiang Liao +5 more
doaj +2 more sources
RNF115 upregulation by YBX1-dependent m5C modification promotes hepatocellular carcinoma progression [PDF]
npj Precision Oncology5-methylcytosine (m5C) RNA modification plays critical roles in post-transcriptional regulation and cancer progression. However, the downstream effectors of the m5C reader protein YBX1 and their mechanistic contribution to hepatocellular carcinoma (HCC ...
Jianhao Li +3 more
doaj +2 more sources
YBX1 regulation of alveolar type II epithelial cells in idiopathic pulmonary fibrosis: mechanistic insights and small-molecule drug screening [PDF]
Journal of Translational MedicineBackground This study aims to systematically elucidate the molecular mechanisms underlying idiopathic pulmonary fibrosis (IPF), with a specific focus on the regulatory role of the nucleic acid-binding protein Y-box binding protein 1 (YBX1) in alveolar ...
Yijie He +11 more
doaj +2 more sources
YBX1 modulates humoral immunity through post-transcriptional regulation in B cells [PDF]
Frontiers in ImmunologyIntroductionY-box binding protein 1 (YBX1) is a multifunctional RNA- and DNA-binding protein implicated in transcriptional regulation, mRNA stabilization, and translation, as well as cell proliferation and stress responses.
Viktoria Kunz +3 more
doaj +2 more sources
Unveiling the immunological functions of the RNA m5C reader YBX1 in cancer [PDF]
Frontiers in ImmunologyY-box binding protein 1 (YBX1) is a multifunctional RNA-binding protein that plays a central role in cancer progression across diverse tumor types. Mechanistically, YBX1 promotes tumorigenesis through multiple pathways, including interactions with long ...
Chunhong Li +3 more
doaj +2 more sources
ybx1 acts upstream of atoh1a to promote the rapid regeneration of hair cells in zebrafish lateral-line neuromasts [PDF]
PeerJLike the sensory organs of the human inner ear, the lateral-line neuromasts (NMs) of fish such as the zebrafish (Danio rerio) contain mechanosensory hair cells (HCs) that are surrounded by supporting cells (SCs).
Caleb C. Reagor +2 more
doaj +3 more sources
Critical role of phosphorylation of serine 165 of YBX1 on the activation of NF-κB in colon cancer. [PDF]
, 2015 Y-box binding protein 1 [YBX1] is a multifunctional protein known to facilitate many of the hallmarks of cancer. Elevated levels of YBX1 protein are highly correlated with cancer progression, making it an excellent marker in cancer.
Hartley, Antja-Voy +10 more
core +11 more sources