Results 11 to 20 of about 7,882 (190)

Transcriptional and post-transcriptional control of autophagy and adipogenesis by YBX1

Cell Death and Disease, 2023
Obesity is strongly associated with metabolic diseases, which have become a global health problem. Exploring the underlying mechanism of adipogenesis is crucial for the treatment of excess white fat.
Ruifan Wu, Shengchun Feng, Fan Li, Gang Shu, Lina Wang, Ping Gao, Xiaotong Zhu, Canjun Zhu, Songbo Wang, Qingyan Jiang   +9 more
doaj   +3 more sources

The interaction of YBX1 with G3BP1 promotes renal cell carcinoma cell metastasis via YBX1/G3BP1-SPP1- NF-κB signaling axis [PDF]

Journal of Experimental & Clinical Cancer Research, 2019
Background Renal cell carcinoma (RCC) is a deadly urological tumor that remains largely incurable. Our limited understanding of key molecular mechanisms underlying RCC invasion and metastasis has hampered efforts to identify molecular drivers with ...
Yong Wang, Jing Su, Yiting Wang, Donghe Fu, Justin E. Ideozu, Hua Geng, Qiqi Cui, Chao Wang, Ruibing Chen, Yixi Yu, Yuanjie Niu, Dan Yue   +11 more
doaj   +3 more sources

Long noncoding RNAs implicated in embryonic development in Ybx1 knockout zebrafish [PDF]

FEBS Open Bio, 2021
Y‐box‐binding protein 1 (Ybx1, YB‐1), also known as Y‐box transcription factor, is involved in a variety of biological processes (BPs) and pathways, including embryogenesis, reproduction and development in vertebrates.
Chen Huang, Bo Zhu, Dongliang Leng, Wei Ge, Xiaohua Douglas Zhang   +4 more
doaj   +3 more sources

PIWI-interacting RNA-YBX1 inhibits proliferation and metastasis by the MAPK signaling pathway via YBX1 in triple-negative breast cancer

Cell Death Discovery
Breast cancer is the second leading cause of death in women worldwide, with triple-negative breast cancer (TNBC) having the worst prognosis. Although there are numerous studies on TNBC, there is no effective treatment for it, and it is still a major ...
Linyu Wu, Shanshan Huang, Wenwen Tian, Peng Liu, Yi Xie, Yu Qiu, Xing Li, Yuhui Tang, Shaoquan Zheng, Yuying Sun, Hailin Tang, Wei Du, Weige Tan, Xinhua Xie   +13 more
doaj   +3 more sources

YBX1 mediates alternative splicing and maternal mRNA decay during pre-implantation development [PDF]

Cell & Bioscience, 2022
Background In mammals, maternal gene products decay and zygotic genome activation (ZGA) during maternal to zygotic transition (MZT) is critical for the early embryogenesis.
Mingtian Deng, Baobao Chen, Zifei Liu, Yongjie Wan, Dongxu Li, Yingnan Yang, Feng Wang   +6 more
doaj   +4 more sources

Selective sorting of microRNAs into exosomes by phase-separated YBX1 condensates [PDF]

eLife, 2021
Exosomes may mediate cell-to-cell communication by transporting various proteins and nucleic acids to neighboring cells. Some protein and RNA cargoes are significantly enriched in exosomes.
Xiao-Man Liu, Liang Ma, Randy Schekman
doaj   +5 more sources

YBX1: A Multifunctional Protein in Senescence and Immune Regulation

Current Issues in Molecular Biology
The Y-box binding protein 1 (YBX1) is a multifunctional protein with a wide range of roles in cell biology. It plays a crucial role in immune modulation, senescence, and disease progression.
Wenze Zhang, Ying Liu, Zhe Zhao, Yizhi Zhang, Yujuan Liang, Wanxia Wang   +5 more
doaj   +3 more sources

Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms [PDF]

Nature, 2020
Janus kinases (JAKs) mediate responses to cytokines, hormones and growth factors in haematopoietic cells1,2. The JAK gene JAK2 is frequently mutated in the ageing haematopoietic system3,4 and in haematopoietic cancers5. JAK2 mutations constitutively activate downstream signalling and are drivers of myeloproliferative neoplasm (MPN).
Ashok Kumar Jayavelu, Tina M. Schnöder, Florian Perner, Carolin Herzog, Arno Meiler, Gurumoorthy Krishnamoorthy, Nicolas Huber, Juliane Mohr, Bärbel Edelmann-Stephan, Rebecca Austin, Sabine Brandt, Francesca Palandri, Nicolas Schröder, Berend Isermann, Frank Edlich, Amit U. Sinha, Martin Ungelenk, Christian A. Hübner, Robert Zeiser, Susann Rahmig, Claudia Waskow, Iain Coldham, Thomas Ernst, Andreas Hochhaus, Stefanie Jilg, Philipp J. Jost, Ann Mullally, Lars Bullinger, Peter R. Mertens, Steven W. Lane, Matthias Mann, Florian H. Heidel   +31 more
openaire   +5 more sources

Expression of YBX1 and FOXA1 in Gastric Cancer and Their Clinicopathological Significance

Zhongliu Fangzhi Yanjiu, 2022
Objective To explore the expression levels of YBX1 and FOXA1 in gastric cancer tissues and determine their relationship with prognosis. Methods A total of 131 patients with gastric cancer were studied, and the corresponding adjacent normal tissues of ...
PEI Zhenghao, ZHANG Hu, WANG Jun, HAO Yang   +3 more
doaj   +1 more source

The Pleiotropic Effects of YBX1 on HTLV-1 Transcription

International Journal of Molecular Sciences, 2023
HTLV-1 is an oncogenic human retrovirus and the etiologic agent of the highly aggressive ATL malignancy. Two viral genes, Tax and Hbz, are individually linked to oncogenic transformation and play an important role in the pathogenic process. Consequently, regulation of HTLV-1 gene expression is a central feature in the viral lifecycle and directly ...
Susan Smith, Jaideep Seth, Amanda Midkiff, Rachel Stahl, Yu-Ci Syu, Nikoloz Shkriabai, Mamuka Kvaratskhelia, Karin Musier-Forsyth, Pooja Jain, Patrick L. Green, Amanda R. Panfil   +10 more
openaire   +2 more sources