DNMT2-m5C-ACLY Axis Promotes Lenvatinib Resistance in Hepatocellular Carcinoma Through Histone Acetylation-Mediated Notch Pathway. [PDF]
Adv Sci (Weinh)Lenvatinib resistance poses a major challenge in advanced hepatocellular carcinoma (HCC). This study reveals that DNMT2 upregulation is a key driver, which stabilizes ACLY mRNA via m5C modification and activates the Notch signaling pathway. Crucially, combining ACLY inhibitors with lenvatinib overcomes resistance and suppresses tumors, offering a ...
Yang S +14 more
europepmc +2 more sources
Uncoupling of EGFR–RAS signaling and nuclear localization of YBX1 in colorectal cancer [PDF]
, 2016 The transcription factor YBX1 can act as a mediator of signals transmitted via the EGFR–RAS–MAPK axis. YBX1 expression has been associated with tumor progression and prognosis in multiple types of cancer.
Bläker, H. +8 more
core +2 more sources
YBX1 as an oncogenic factor in T-cell acute lymphoblastic leukemia
Blood Advances, 2023 Abstract Y-box-binding protein 1 (YBX1), a member of the RNA-binding protein family, is a critical regulator of cell survival in various solid tumors and acute myeloid leukemia. However, the function of YBX1 in T-cell acute lymphoblastic leukemia (T-ALL) remains elusive.
Huan Li +12 more
openaire +2 more sources
C1QBP Regulates YBX1 to Suppress the Androgen Receptor (AR)-Enhanced RCC Cell Invasion
Neoplasia: An International Journal for Oncology Research, 2017 Early studies suggested that the androgen receptor (AR) might play important roles to promote the renal cell carcinoma (RCC) progression; however, the detailed mechanisms remain unclear.
Dan Yue +4 more
doaj +1 more source
Cell Death and Disease, 2022 NSCLC is common and is the primary cause of cancer-related deaths due to a lack of early diagnosis and its propensity for metastasis. The pathogenesis of NSCLC is still unclear.
HongBo Su +3 more
doaj +1 more source
Novel Serine 176 Phosphorylation of YBX1 Activates NF-κB in Colon Cancer [PDF]
, 2017 Y box protein 1 (YBX1) is a well known oncoprotein that has tumor-promoting functions. YBX1 is widely considered to be an attractive therapeutic target in cancer.
Hartley, Antja-Voy +8 more
core +1 more source
White adipose remodeling during browning in mice involves YBX1 to drive thermogenic commitment
Molecular Metabolism, 2021 Objective: Increasing adaptive thermogenesis by stimulating browning in white adipose tissue is a promising method of improving metabolic health. However, the molecular mechanisms underlying this transition remain elusive.
Atefeh Rabiee +15 more
doaj +1 more source
YBX1 gene silencing inhibits migratory and invasive potential via CORO1C in breast cancer in vitro [PDF]
, 2017 Non-coding genes that were differentially expressed following YB-1 silencing in MDA-MB-231 cells.
Boon Huat Bay +5 more
core +4 more sources
Keeping a lid on nodal : transcriptional and translational repression of nodal signalling [PDF]
, 2016 Nodal is an evolutionarily conserved member of the transforming growth factor-β (TGF-β) superfamily of secreted signalling factors. Nodal factors are known to play key roles in embryonic development and asymmetry in a variety of organisms ranging from ...
Robertson, Elizabeth J., Sampath, Karuna
core +1 more source
Human interactome of the influenza B virus NS1 protein [PDF]
, 2017 This work was partially supported by NIAID grant U19AI106754, and by CRIP (Center for Research in Influenza Pathogenesis), an NIAID funded Center of Excellence for Influenza Research and Surveillance (CEIRS, contract #HHSN272201400008C) to A. G-S.
Botting, Catherine H. +4 more
core +1 more source