Results 61 to 70 of about 7,882 (190)

Tumor‐Derived Exosomal TAGLN2 Promotes Metastasis by Inducing Vascular Permeability and Angiogenesis via the NRP1/SEMA4D/YAP Axis

Advanced Science, EarlyView.
Gastric cancer‐derived exosomal TAGLN2 is identified as a key mediator of vascular reprogramming, with significantly elevated levels detected in patient serum. Independent of canonical SEMA4D signaling, it nucleates a cytoplasmic TAGLN2/NRP1/SEMA4D ternary complex that dually activates YAP, promoting angiogenesis, vascular dysfunction, and metastasis ...
Shuqi Yu, Jiajia Zhuo, Xiaoquan Hong, Shihao Rao, Yafang Ye, Dandan Kang, Huifang Peng, Huiqin Zhuo   +7 more
wiley   +1 more source

An Always Correlated gene expression landscape for ovine skeletal muscle, lessons learnt from comparison with an “equivalent” bovine landscape [PDF]

, 2012
BACKGROUND: We have recently described a method for the construction of an informative gene expression correlation landscape for a single tissue, longissimus muscle (LM) of cattle, using a small number (less than a hundred) of diverse samples.
Antonio Reverter, Ashley J Waardenberg, Brian P Dalrymple, Keren Byrne, Nicholas J Hudson, Ross L Tellam, Tony Vuocolo, Wei Sun   +7 more
core   +1 more source

Overexpression of YBX1 Promotes Pancreatic Ductal Adenocarcinoma Growth via the GSK3B/Cyclin D1/Cyclin E1 Pathway

Molecular Therapy: Oncolytics, 2020
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers due to frequently late diagnosis and futile treatment. It is a crucial necessity to determine the mechanisms of PDAC.
Zhiqiang Liu, Yongfeng Li, Xiaogang Li, Jingyuan Zhao, Shihong Wu, Heshui Wu, Shanmiao Gou   +6 more
doaj   +1 more source

A cell-based assay for CD63-containing extracellular vesicles [PDF]

, 2019
Extracellular vesicles (EVs) are thought to be important in cell-cell communication and have elicited extraordinary interest as potential biomarkers of disease. However, quantitative methods to enable elucidation of mechanisms underlying release are few.
Cashikar, Anil G, Hanson, Phyllis I
core   +2 more sources

5‐Methylcytosine Analysis of miRNAs in Minimal Change Disease

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Minimal change disease (MCD) is a glomerular disorder, which is the most common cause of nephrotic syndrome in children. Additionally, the prevalence of MCD in adults has been increasing in recent years. During protein synthesis, noncoding RNAs can be regulated through a variety of modifications, which helps preserve biological diversity and ...
Huiyi Zeng, Dandan Li, Yunyi Li, Chen Yun, Xinzhou Zhang, Wenyu Gong, Mengyun Xiao, Haitao Li, Zhipeng Zeng, Ruqi Tan, Yishen Yang, Shaodong Luan, Yong Dai, Lianghong Yin, Donge Tang   +14 more
wiley   +1 more source

YBX1 regulates tumor growth via CDC25a pathway in human lung adenocarcinoma

Oncotarget, 2016
Y-box binding protein 1 (YBX1) is involved in the multi-tumor occurrence and development. However, the regulation of YBX1 in lung tumorigenesis and the underlying mechanisms, especially its relationship with CDC25a, was remains unclear. In this study, we analyzed the expression and clinical significance of YBX1 and CDC25a in lung adenocarcinoma and ...
Zhao, Shilei, Wang, Yan, Guo, Tao, Yu, Wendan, Li, Jinxiu, Tang, Zhipeng, Yu, Zhenlong, Zhao, Lei, Zhang, Yixiang, Wang, Ziyi, Wang, Peng, Li, Yechi, Li, Fengzhou, Sun, Zhe, Xuan, Yang, Tang, Ranran, Deng, Wu-guo, Guo, Wei, Gu, Chundong   +18 more
openaire   +3 more sources

KMT2D‐mediated H3K4me1 recruits YBX1 to facilitate triple‐negative breast cancer progression through epigenetic activation of c‐Myc

Clinical and Translational Medicine
Background Lysine methyltransferase 2D (KMT2D) mediates mono‐methylation of histone H3 lysine 4 (H3K4me1) in mammals. H3K4me1 mark is involved in establishing an active chromatin structure to promote gene transcription.
Bing Yao, Mengying Xing, Xiangwei Zeng, Ming Zhang, Que Zheng, Zhi Wang, Bo Peng, Shuang Qu, Lingyun Li, Yucui Jin, Haitao Li, Hongyan Yuan, Quan Zhao, Changyan Ma   +13 more
doaj   +1 more source

USP21/YBX1/HIF1-α promotes the progression of prostate cancer. [PDF]

J Transl Med
Gu Z, Zou L, Jiang C, Qi F, Huang D, Liu J, Guo Y, Mao S, Zhang J, Zhang Y, Shi D, Geng J, Chen Y, Zhang W, Yao X.   +14 more
europepmc   +3 more sources

Critical role of phosphorylation of serine 165 of YBX1 on the activation of NF- B in colon cancer [PDF]

, 2015
poster abstractY-box binding protein 1 (YBX1) is a multifunctional protein known to facilitate many of the hallmarks of cancer. Elevated levels of YBX1 protein are highly correlated with cancer progression, making it an excellent marker in cancer.
Hartley, Antja-Voy, Liu, Yunlong, Lu, Tao, McElyea, Kyle, Mundade, Rasika, Prabhu, Lakshmi, Sandusky, George, Temm, Constance J., Wang, Benlian, Wei, Han   +9 more
core  

Gut microbiome‐derived metabolites show promise in cancer research and therapy

Interdisciplinary Medicine, EarlyView.
The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du   +4 more
wiley   +1 more source