Results 271 to 280 of about 1,258,398 (362)

Is Enhancer Function Driven by Protein–Protein Interactions? From Bacteria to Leukemia

open access: yesBioEssays, EarlyView.
Enhancers are key regulatory elements that are conceptually conserved from bacteria to humans. Enhancer dysregulation is common in cancers, including leukemia. We argue that highly specific protein–protein interactions, including transcription factors, mediate enhancer‐promoter proximity to allow enhancer‐bound factors to directly act on RNA polymerase
Nicholas T. Crump, Thomas A. Milne
wiley   +1 more source

Engineering Affibody Binders to Death Receptor 5 and Tumor Necrosis Factor Receptor 1 With Improved Stability

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Protein developability is an important, yet often overlooked, aspect of protein discovery campaigns that is a key driver of utility. Recent advances have improved developability screening capacity, making it an increasingly viable option in early‐stage discovery.
Gregory H. Nielsen   +2 more
wiley   +1 more source

Sigma Factors as Potential Targets to Enhance Recombinant Protein Expression

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT The transcriptional factors control the expression of many genes and represent an important layer of complexity in cell factories. However, the effect of individual sigma factor deletions from a biomanufacturing perspective has not been addressed. In this contribution, growth, green fluorescence protein (GFP) expression, and oxygen consumption
Laura Pohlen   +6 more
wiley   +1 more source

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