Results 111 to 120 of about 257,444 (202)

Cancer therapy via neoepitope-specific monoclonal antibody cocktails

Cancer Immunology, Immunotherapy
Cellular heterogeneity presents a significant challenge to cancer treatment. Antibody therapies targeting individual tumor-associated antigens can be extremely effective but are not suited for all patients and often fail against tumors with heterogeneous
Colin J. Hartman, Asmaa O. Mohamed, Girja S. Shukla, Stephanie C. Pero, Yu-Jing Sun, Roberto S. Rodríguez-Jimenez, Nicholas F. Genovese, Nico M. Kohler, Thomas R. Hemphill, Yina H. Huang, David N. Krag, Margaret E. Ackerman   +11 more
doaj   +1 more source

Yeast display platform with expression of linear peptide epitopes for high-throughput assessment of peptide-MHC-II binding. [PDF]

J Biol Chem, 2023
Huisman BD, Balivada PA, Birnbaum ME.
europepmc   +1 more source

A high-throughput yeast display approach to profile pathogen proteomes for MHC-II binding. [PDF]

Elife, 2022
Huisman BD, Dai Z, Gifford DK, Birnbaum ME.   +3 more
europepmc   +1 more source

Edge usage, motifs and regulatory logic for cell cycling genetic networks

, 2013
The cell cycle is a tightly controlled process, yet its underlying genetic network shows marked differences across species. Which of the associated structural features follow solely from the ability to impose the appropriate gene expression patterns?
Krzywicki, A., Martin, O. C., Zagorski, M.   +2 more
core   +3 more sources

Highly protective antimalarial antibodies via precision library generation and yeast display screening. [PDF]

J Exp Med, 2022
Banach BB, Tripathi P, Da Silva Pereira L, Gorman J, Nguyen TD, Dillon M, Fahad AS, Kiyuka PK, Madan B, Wolfe JR, Bonilla B, Flynn B, Francica JR, Hurlburt NK, Kisalu NK, Liu T, Ou L, Rawi R, Schön A, Shen CH, Teng IT, Zhang B, Pancera M, Idris AH, Seder RA, Kwong PD, DeKosky BJ.   +26 more
europepmc   +1 more source

Correlating single-molecule rupture mechanics with cell population adhesion by yeast display. [PDF]

Biophys Rep (N Y), 2022
Santos MS, Liu H, Schittny V, Vanella R, Nash MA.   +4 more
europepmc   +1 more source

Proteome-Scale Screening to Identify High-Expression Signal Peptides with Minimal N-Terminus Biases via Yeast Display. [PDF]

ACS Synth Biol, 2022
Holec PV, Camacho KV, Breuckman KC, Mou J, Birnbaum ME.   +4 more
europepmc   +1 more source

A Protein-Engineered, Enhanced Yeast Display Platform for Rapid Evolution of Challenging Targets. [PDF]

ACS Synth Biol, 2021
Zahradník J, Dey D, Marciano S, Kolářová L, Charendoff CI, Subtil A, Schreiber G.   +6 more
europepmc   +1 more source

Measuring the capacity of yeast for surface display of cell wall‐anchored protein isoforms by using β‐lactamase as a reporter enzyme

FEBS Open Bio
Yeast surface display is a promising biotechnological tool that uses genetically modified yeast cell wall proteins as anchors for enzymes of interest, thereby transforming yeast cell wall into a living catalytic material. Here, we present a comprehensive
Tea Martinić Cezar, Antonia Paić, Stefani Prekpalaj, Renata Teparić, Bojan Žunar, Igor Stuparević   +5 more
doaj   +1 more source

Reduction of therapeutic antibody self-association using yeast-display selections and machine learning. [PDF]

MAbs, 2022
Makowski EK, Chen H, Lambert M, Bennett EM, Eschmann NS, Zhang Y, Zupancic JM, Desai AA, Smith MD, Lou W, Fernando A, Tully T, Gallo CJ, Lin L, Tessier PM.   +14 more
europepmc   +1 more source