Results 41 to 50 of about 257,444 (202)

Drug-like antibodies with high affinity, diversity and developability directly from next-generation antibody libraries

mAbs, 2021
Therapeutic antibodies must have “drug-like” properties. These include high affinity and specificity for the intended target, biological activity, and additional characteristics now known as “developability properties”: long-term stability and resistance
Andre Azevedo Reis Teixeira, Michael Frank Erasmus, Sara D’Angelo, Leslie Naranjo, Fortunato Ferrara, Camila Leal-Lopes, Oliver Durrant, Cecile Galmiche, Aleardo Morelli, Anthony Scott-Tucker, Andrew Raymon Morton Bradbury   +10 more
doaj   +1 more source

Nanoscale integration of single cell biologics discovery processes using optofluidic manipulation and monitoring. [PDF]

, 2019
The new and rapid advancement in the complexity of biologics drug discovery has been driven by a deeper understanding of biological systems combined with innovative new therapeutic modalities, paving the way to breakthrough therapies for previously ...
Chen, Ching, Chen, Irwin, Chong, Su, Hamburger, Agi, Jess, Philip, Jorgolli, Marsela, Le, Kim, Lin, Fen-Fen, Miranda, Les P, Mock, Marissa, Munro, Trent, Nevill, Tanner, Stevens, Jennitte, Tagari, Philip, Tan, Christopher, Winters, Aaron, Wu, Ming, Xu, Han   +17 more
core   +1 more source

VNAR development through antigen immunization of Japanese topeshark (Hemitriakis japanica)

Frontiers in Bioengineering and Biotechnology, 2023
The VNAR (Variable New Antigen Receptor) is the smallest single-domain antibody derived from the variable domain of IgNAR of cartilaginous fishes. Despite its biomedical and diagnostic potential, research on VNAR has been limited due to the difficulties ...
Hiroyuki Takeda, Tatsuhiko Ozawa, Tatsuhiko Ozawa, Hiroki Zenke, Yoh Ohnuki, Yuri Umeda, Wei Zhou, Honoka Tomoda, Akihiko Takechi, Kimiyoshi Narita, Takaaki Shimizu, Takuya Miyakawa, Yuji Ito, Tatsuya Sawasaki   +13 more
doaj   +1 more source

The yeast P5 type ATPase, Spf1, regulates manganese transport into the endoplasmic reticulum [PDF]

, 2013
The endoplasmic reticulum (ER) is a large, multifunctional and essential organelle. Despite intense research, the function of more than a third of ER proteins remains unknown even in the well-studied model organism Saccharomyces cerevisiae.
A Chesi, A Samali, A Szkopińska, AB Bowman, AD Gitler, AH Futerman, Alaa Abdul-Sada, Anthony H. Futerman, AR Reddi, C Janke, C Onyewu, C Suzuki, C Suzuki, CB Brachmann, CC Paulusma, CD Davis, D Berchtold, D Lockshon, D Mandal, D Sorger, DJ Tipper, DK Breslow, E Losev, E Papanikou, E Sammels, E Wiederhold, EH Hettema, F Sherman, Fischl, Frances M. Platt, G Giaever, GA Castillon, GA Castillon, Giuseppe Condomitti, GK Voeltz, GR Corradi, H Yoshida, Howard Riezman, I Braakman, Isabelle Riezman, J Ko, J Meldolesi, J Shima, JA Sullivan, JK Pittman, JM De Freitas, K Araki, K Krumpe, KB Axelsen, LJ Wuestehube, LS Weingarten, LT Jensen, M Fujita, M Fujita, M Fujita, M North, M Schuldiner, M Schuldiner, Maya Schuldiner, MC Jonikas, MS Bae-Lee, Márton Megyeri, N Rimon, Nitzan Rimon, NP Mira, Oscar C. W. Chen, P Estrada de Martin, P Fagone, PJ Schultheis, PL Pedersen, RC Dickson, RC Dickson, RD Gietz, S Ichikawa, S Vashist, S-X Tan, SA Heidler, SC Dos Santos, SL Hansen, SR Cronin, SR Cronin, Stephen W. Michnick, TP Levine, U Loizides-Mangold, Ursula Loizides-Mangold, V Cerantola, V V Kushnirov, VC Culotta, W Kühlbrandt, X Tang, X Zhou, XF Liu, XL Guan, Y Chen, YD Lobsanov, Yifat Cohen   +95 more
core   +7 more sources

Exploiting next-generation sequencing in antibody selections – a simple PCR method to recover binders

mAbs, 2020
Antibody discovery using invitro display technologies such as phage and/or yeast display has become acornerstone in many research and development projects, including the creation of new drugs for clinical use.
Fortunato Ferrara, Andre A. Teixeira, Leslie Naranjo, M. Frank Erasmus, Sara D’Angelo, Andrew R.M. Bradbury   +5 more
doaj   +1 more source

Generation of Lamprey Monoclonal Antibodies (Lampribodies) Using the Phage Display System. [PDF]

, 2019
The variable lymphocyte receptors (VLRs) consist of leucine rich repeats (LRRs) and comprise the humoral antibodies produced by lampreys and hagfishes.
Amemiya, Chris T, Hansen, John D, Hassan, Khan MA, Herrin, Brantley R   +3 more
core   +2 more sources

Molecular Display Technology Using Yeast—Arming Technology—

Analytical Sciences, 2009
A technology to display proteins or peptides on living organisms has been developed over the last two decades. So-called "Molecular display (Arming) technology" or "Cell surface engineering" has been one of the important tools for analyzing and understanding protein function, or for screening of novel clones from libraries. In addition, it endows cells
Seiji, Shibasaki, Hatsuo, Maeda, Mitsuyoshi, Ueda   +2 more
openaire   +3 more sources

Development of Recombinant Antibody by Yeast Surface Display Technology

Current Research in Pharmacology and Drug Discovery
Recombinant antibodies have emerged as powerful tools in various fields, including therapeutics, diagnostics, and research applications. The selection of high-affinity antibodies with desired specificity is a crucial step in the development of ...
Mujahed I. Mustafa, Awad A. Alzebair, Ahmed Mohammed   +2 more
doaj   +1 more source

Visualizing Gene Clusters using Neighborhood Graphs in R [PDF]

, 2008
The visualization of cluster solutions in gene expression data analysis gives practitioners an understanding of the cluster structure of their data and makes it easier to interpret the cluster results.
Leisch, Friedrich, Scharl, Theresa
core   +1 more source

High‐throughput screening and biological display technology: Applications in molecular imaging

iRADIOLOGY, 2023
Molecular imaging plays important roles in many fields, including disease diagnosis, therapeutic efficacy evaluation, intraoperative imaging guidance, drug metabolism monitoring, and patient selection for appropriate treatment.
Renli Luo, Hongguang Liu, Zhen Cheng
doaj   +1 more source