Results 21 to 30 of about 258,986 (286)
Evaluation of the yeast surface display system for screening of functional nanobodies
AMB Express, 2020 Yeast surface display is a powerful technology used to isolate and engineer proteins to improve their activity, specificity, and stability. In this method, gene expression is regulated by promoters, and secretion efficiency is affected by secretion ...
Kaho Kajiwara +2 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2020 Affinity chromatography provides an excellent platform for protein purification, which is a key step in the large scale downstream processing of therapeutic monoclonal antibodies (Mabs).
Steffen C. Hinz +10 more
doaj +1 more source
Journal of Extracellular Vesicles, 2021 The research of extracellular vesicles (EVs) has boomed in the last decade, with the promise of them functioning as target‐directed drug delivery vehicles, able to modulate proliferation, migration, differentiation, and other properties of the recipient ...
Stefan Vogt +7 more
doaj +1 more source
Microorganisms, 2023 In the long history of microorganism use, yeasts have been developed as hosts for producing biologically active compounds or for conventional fermentation.
Seiji Shibasaki, Mitsuyoshi Ueda
doaj +1 more source
The Use of Yeast in Biosensing
Microorganisms, 2022 Yeast has been used as a model for several diseases as it is the simplest unicellular eukaryote, safe and easy to culture and harbors most of the fundamental processes that are present in almost all higher eukaryotes, including humans. From understanding
Sudip Dhakal, Ian Macreadie
doaj +1 more source
Yeast Surface-Displayed H5N1 Avian Influenza Vaccines [PDF]
Journal of Immunology Research, 2016 Highly pathogenic H5N1 avian influenza viruses pose a pandemic threat to human health. A rapid vaccine production against fast outbreak is desired. We report, herein, a paradigm-shift influenza vaccine technology by presenting H5N1 hemagglutinin (HA) to the surface of yeast.
Han Lei +4 more
openaire +3 more sources
Microbiology Spectrum, 2015 ABSTRACT Despite the availability of antimicrobial drugs, the continued development of microbial resistance—established through escape mutations and the emergence of resistant strains—limits their clinical utility. The discovery of novel, therapeutic, monoclonal antibodies (mAbs) offers viable clinical alternatives in the ...
Jared, Sheehan, Wayne A, Marasco
openaire +2 more sources
The replicative lifespan-extending deletion of SGF73 results in altered ribosomal gene expression in yeast. [PDF]
, 2017 Sgf73, a core component of SAGA, is the yeast orthologue of ataxin-7, which undergoes CAG-polyglutamine repeat expansion leading to the human neurodegenerative disease spinocerebellar ataxia type 7 (SCA7).
Garza, Renee M +6 more
core +2 more sources
Strategies to Screen Anti-AQP4 Antibodies from Yeast Surface Display Libraries
Antibodies, 2022 A rapid and effective method to identify disease-specific antibodies from clinical patients is important for understanding autoimmune diseases and for the development of effective disease therapies.
Aric Huang +11 more
doaj +1 more source
Enhanced yeast one-hybrid screens to identify transcription factor binding to human DNA sequences [PDF]
, 2019 Identifying the sets of transcription factors (TFs) that regulate each human gene is a daunting task that requires integrating numerous experimental and computational approaches.
Fuxman Bass, Juan +3 more
core +1 more source