Results 91 to 100 of about 111,329,672 (189)
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.This review elucidates how lactylation, a novel histone modification driven by lactate, regulates colorectal cancer pathogenesis. We summarize its roles in tumor progression, metastasis, stemness, immunosuppression, and therapy resistance, and discusses the promising therapeutic strategies of targeting the lactylation pathway.
Shuilan Yao +4 more
wiley +1 more source
Molecular interplay between linc01134 and YY1 dictates hepatocellular carcinoma progression
Journal of Experimental & Clinical Cancer Research, 2020 Background Revealing the mechanical role of long non-coding RNAs (lncRNAs) in tumorigenesis can contribute to novel therapeutic target for cancers. The regulatory role of linc01134 in hepatocellular carcinoma (HCC) has not been studied yet. Materials and
Zhonghou Rong +4 more
doaj +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.ABSTRACT Background Dnajb5, a member of the heat shock protein family, has not been previously reported to play a role in muscle differentiation. We identify Dnajb5 as a negative regulator of myogenesis via mammalian target of rapamycin (mTOR) and histone deacetylase 4 (HDAC4) signalling, functioning as a central controller of muscle growth and ...
Sun‐Hee Cho +8 more
wiley +1 more source
An analysis of genes regulated by the multi-functional transcriptional regulatory Yin Yang-1
, 1994 Yin Yang-1 (YY1) is a zinc finger protein (1) which posesses the unusual property of regulating transcription in three ways. In different gene contexts, YY1 has been shown to activate transcription, repress transcription or initiate transcription ...
Kathryn Calame, Ajay Shrivastava
core
The FASEB Journal, Volume 40, Issue 14, 31 July 2026.This study explores the molecular mechanisms by which NaB ameliorates liver fibrosis from the perspectives of the gut–liver axis and metabolic reprogramming. In vivo and in vitro experiments demonstrate that gut‐derived NaB may alleviate liver injury and fibrosis by inhibiting hepatic stellate cell activation and aerobic glycolysis through the HDAC3/c ...
Yong Sun +8 more
wiley +1 more source
Modulation of YY1 activity by SAP30
, 2008 [[abstract]]Yin Yang 1 (YY1) is a highly conserved and multifunctional transcription factor. The diverse activities of YY1 are regulated and sometimes modified by interaction with various other proteins.
Huang, NE; Lin, CH; Lin, YS; Yu, WCY
core +1 more source
PLoS ONE, 2011 Yin-Yang 1 (YY1) is an essential multifunctional zinc-finger protein. It has been shown over the past two decades to be a critical regulator of a vast array of biological processes, including development, cell proliferation and differentiation, DNA ...
Raed Rizkallah +4 more
doaj +1 more source
Genome-wide Analysis of YY2 Versus YY1 Target Genes [PDF]
, 2011 Yin Yang 1 (YY1) is a critical transcription factor controlling cell proliferation, development and DNA damage responses. Retrotranspositions have independently generated additional YY family members in multiple species.
Coser, Kathryn R. +5 more
core +1 more source
Role of the transcription factor yy1 in b cell non-hodgkin lymphoma development
Hematology Reports, 2020 Introduction Yin Yang 1 (YY1) is a transcription factor with a dual role in cancer. B-cell non-Hodgkin lymphomas (B-NHLs) are often characterized by the development of recurrence and/or resistance to therapy.
S. Vivarelli, L. Falzone, M. Libra
doaj
Biochimica et Biophysica Acta (BBA) - Reviews on CancerSpatial transcriptomics (ST) plays a pivotal role in cancer research, offering a unique perspective on gene expression within the cancer microenvironment, further revolutionizing our current understanding of the subject. From addressing the limitations of traditional bulk RNA sequencing by preserving spatial context, this review discusses the ...
Dommalapati, Lekhya +6 more
openaire +3 more sources