Results 101 to 110 of about 111,329,672 (189)

The Yin and Yang of pain: variability in formalin test nociception and morphine analgesia produced by the Yin Yang 1 transcription factor gene

, 2013
International audienceWe recently observed a reliable phenotypic difference in the inflammatory pain sensitivity of a congenic mouse strain compared to its background strain.
Melmed, K., Austin, J., Sotocinal, S., Mogil, J., Sorge, A, Tuttle, A., Naumova, A., Khoutorsky, A., Labialle, Stéphane, Sorge, R., Wood, J., Schmidt, J., Lacroix-Fralish, M.   +12 more
core   +1 more source

Multifunctional Transcription Factor Yy1: A Therapeutic Target in Human Cancer?

, 2009
The multifunctional transcription factor Yin Yang 1 (YY1) is a complex protein that has been shown to play pivotal roles in development, differentiation, cellular proliferation and apoptosis. It can act as a transcriptional repressor, an activator, or an
陳健尉;楊泮池, CHEN, JEREMY J. W.;YANG, PAN-CHYR   +1 more
core  

YY1 downregulation underlies therapeutic response to molecular targeted agents

Cell Death and Disease
During targeted treatment, oncogene-addicted tumor cells often evolve from an initial drug-sensitive state through a drug-tolerant persister bottleneck toward the ultimate emergence of drug-resistant clones.
Shichao Zhou, Jingyu Zang, Mei-Chun Cai, Kaiyan Ye, Jin Liu, Pengfei Ma, Jie Wu, Chenyang Dai, Haijiao Lu, Qing Zhang, Junhong Jiang, Tianqing Chu, Ying Shen, Li Tan, Guanglei Zhuang, Xiaojing Zhao, Lan Wang, Yu Zhuang, Yujie Fu   +18 more
doaj   +1 more source

Transcription factor Yin Yang 1 (YY1) mediates Prostaglandin F2α (PGF2α) suppression of Steroidogenic Acute Regulatory Protein (StAR) expression via selective promoter site binding in vivo

The FASEB Journal, 2007
PGF2α plays a pivotal role in ovarian luteolysis by inhibiting the expression of StAR leading to a decrease in intracellular cholesterol transport and luteal steroid production. Previously we have demonstrated in vitro that the transcription factor YY1 binds to three regions in the StAR ...
Qiyuan Liu, Kathleen A Merkler, Xiaohui Zhang, Mark P McLean   +3 more
openaire   +1 more source

Multifunctional transcription factor YY1: a therapeutic target in human cancer?

, 2014
The multifunctional transcription factor Yin Yang 1 (YY1) is a complex protein that has been shown to play pivotal roles in development, differentiation, cellular proliferation and apoptosis. It can act as a transcriptional repressor, an activator, or an
Wang, C.C., Yang, P.C., 陳健尉, Chen, J.J.W.   +3 more
core   +1 more source

YY1 Negatively Regulates Mouse Myelin Proteolipid Protein () Gene Expression in Oligodendroglial Cells

ASN Neuro, 2011
YY1 (Yin and Yang 1) is a multifunctional, ubiquitously expressed, zinc finger protein that can act as a transcriptional activator, repressor, or initiator element binding protein.
Olga E Zolova, Patricia A Wight
doaj   +1 more source

miRNA-584-3p inhibits gastric cancer progression by repressing Yin Yang 1- facilitated MMP-14 expression

, 2017
Recent evidence shows the emerging roles of promoter-targeting endogenous microRNAs (miRNAs) in regulating gene transcription. However, miRNAs affecting the transcription of matrix metalloproteinase 14 (MMP-14) in gastric cancer remain unknown.
Lin Ye, Feng Yang, Huanhuan Li, Kai Huang, Yajun Chen, Wanju Jiao, Hong Mei, Qiangsong Tong, Liduan Zheng, Huajie Song, Dan Li   +10 more
core   +1 more source

The novel role of Yin Yang 1 in acute rejection of liver allografts through activation of dendritic cells [PDF]

IntroductionAcute rejection is a critical complication after liver transplantation, contributing significantly to transplant dysfunction and recipient mortality.
Hongtao Wang, Yi Chen, Lihong Chen, Jie Wang, Liping Hong, Wubing He   +5 more
core   +1 more source

Yin Yang i as an epimodulator of miRNAs in the metastatic cascade

, 2017
Yin Yang 1 (YY1) belongs to the polycomb group (PcG) of proteins that modify chromatin epigeneti-cally during dynamic regulation of their target genes. The predominant feature of YY1 is the zinc finger, an ancient structural motif that mediates protein ...
Ruosi C., Di Salvatore M. G., Miceli R., Cimmino A., Colella G., Fazioli F., Gallo M., De Nigris F.   +7 more
core   +1 more source

Yin Yang 1 positively regulates BRCA1 and inhibits mammary cancer formation

, 2011
Expression of the breast cancer-associated gene 1 (BRCA1) in sporadic breast cancers is usually reduced, yet the underlying mechanisms remains elusive.
M-H Lee, T Lahusen, He, W-W, Y-S Hwang, Lahusen, T, Xu, X, W-W He, Lee, M-H, Xiao, C, X Xu, Deng, C-X, Hwang, Y-S, Wang, R-H, R-H Wang, Y Shi, C-X Deng, C Xiao, Shi, Y   +17 more
core   +1 more source