Results 151 to 160 of about 111,329,672 (189)

Localization and regulatory function of Yin Yang 1 (YY1) in chicken testis

Molecular Genetics and Genomics, 2021
In mammals, Yin Yang 1 (YY1), a pervasively expressed transcription factor related to many biological processes as an activator or inhibitor of the transcription of various genes, plays a critical role in the development of male gonads and spermatogenesis.
Ligen Chen, Lingyun Qiao, Yan Guo, Ying Huang, Wei Luo, Yanping Feng   +5 more
openaire   +2 more sources

Prognostic Significance of Both the Cytoplasmic and Nuclear Overexpression of Yin-Yang 1 (YY1) Among Patients With Multiple Myeloma (MM)

Blood, 2008
Abstract Objective and Rationale Yin-Yang 1 (YY1) is a multi-functional DNA-binding protein, which can activate, repress or initiate transcription depending on the context in which it binds. In addition, YY1 can modulate protein levels or activity through protein-protein interaction.
Benjamin Bonavida, Stavroula Baritaki, Massimo Libra   +2 more
exaly   +4 more sources

YY1 (Yin‐Yang 1), a transcription factor regulating systemic inflammation, is involved in cognitive impairment of depression

Psychiatry and Clinical Neurosciences, 2022
AimClinical and preclinical studies suggest that alterations in the peripheral and brain immune system are associated with the pathophysiology of depression, also leading to changes in local glucose metabolism in the brain. Here, the authors identified Yin‐Yang 1 (YY1), a transcription factor closely associated with central and peripheral inflammation ...
Jing Lu, Kangyu Jin, Jianping Jiao, Ripeng Liu, Tingting Mou, Bing Chen, Zhihan Zhang, Chaonan Jiang, Haoyang Zhao, Zheng Wang, Rui Zhou, Manli Huang   +11 more
openaire   +2 more sources

Epigenetic regulation of enhancer of zeste homolog 2 (EZH2) -Yin Yang 1 (YY1) axis in cancer

Pathology - Research and Practice, 2023
In accordance with the World Health Organization, cancer is the second leading cause of death in patients. In recent years, the number of cancer patients has been growing, and the occurrence of cancer in people is becoming more common, primarily due to lifestyle factors. Yin Yang 1 (YY1) is a transcription factor that is widespread throughout.
Nikhil, Chandnani, Ishika, Gupta, Vidhi, Thakkar, Koustav, Sarkar   +3 more
openaire   +2 more sources

Yin Yang 1 (YY1) Acting Primarily as an Oncogene and Rarely as a Tumor Suppressor in Distinct Hematological Malignancies: Prognostic and Therapeutic Implications

Blood, 2016
Abstract Yin Yang 1 (YY1) is a transcription factor that is ubiquitously expressed in many normal and cancerous tissues. This transcription factor was reported to have contradictory functions, consistent with its name, and it was shown to either activate and/or repress several gene products.
Benjamin Bonavida, Massimo Libra
exaly   +2 more sources

262-OR: The Transcription Factor Yin Yang 1 (YY1) Is Critical to Beta-Cell Maintenance and Glucose Homeostasis

Diabetes, 2020
Diabetes is characterized by loss of β cell mass and function. mTORC1 has an important role in the control of insulin secretion, β cell proliferation and death. YY1 is important in development, apoptosis, metabolism and growth in several tissues. In muscle, mTORC1 regulates the expression of insulin signaling genes by controlling YY1 binding to the ...
FLAVIA LETÍCIA M. PEÇANHA, ERNESTO BERNAL-MIZRACHI   +1 more
openaire   +1 more source

Abstract P4-05-13: Prognostic implication of Yin Yang 1 (YY1) overexpression in patients with primary breast cancer

Cancer Research, 2022
Abstract Background: YY1 is conserved transcriptional factor that highly expressed in various types of cancers. It regulates differential epigenetic pathways and protein modifications. However, there is still unknown whether YY1 overexpression has any prognostic significance in breast cancer patients.
Chihwan Cha, Hosub Park, Chul Geun Kim, Min Sung Chung   +3 more
openaire   +1 more source

Role of Yin Yang 1 (YY1) on Microenvironment, Signaling Pathways, and Epigenetics in Lung Cancer

Biochimica Et Biophysica Acta: Reviews on Cancer
Lung cancer is a significant health concern worldwide. It is caused by smoking and exposure to carcinogens, although other factors like genetics, epigenetics, and transcription factors also play a role. Yin Yang 1 (YY1) is a transcription factor with a multifaceted role in regulating cellular functions in various cancers.
Seema Kumari, Ganji Purnachandra Nagaraju, Prashen Chelikani   +2 more
exaly   +3 more sources

Role of Yin Yang-1 (YY1) in the transcription regulation of the multi-drug resistance ( MDR1 ) gene

Leukemia & Lymphoma, 2018
Resistance to chemotherapy hinders the successful treatment of acute lymphoblastic leukemia (ALL). The multi-drug resistance-1 (MDR1/ABCB1) gene encodes P-glycoprotein (P-gp), which plays an important role in chemoresistance; however, its transcriptional regulation remains unclear.
Gabriela, Antonio-Andrés, Jesus, Rangel-Santiago, Belen, Tirado-Rodríguez, Gustavo U, Martinez-Ruiz, Miguel, Klunder-Klunder, Mario I, Vega, Briceida, Lopez-Martinez, Elva, Jiménez-Hernández, Jose, Torres Nava, Aurora, Medina-Sanson, Sara, Huerta-Yepez   +10 more
openaire   +2 more sources

Photodynamic Therapy (PDT)-Mediated Inhibition of the Transcription Factor Yin Yang 1 (YY1) That Regulates Resistance In Lymphoma

Blood, 2010
Abstract Abstract 5113 Photodynamic therapy (PDT) is a cancer therapeutic treatment that uses a compound called the “photosensitizer” and a particular type of visible light. When photosensitizers are exposed to a specific wavelength of light (600-800 nm), cytotoxic oxygen species are generated that kill cells (Dougherty ...
Valentina Rapozzi, Sara Huerta-Yepez, Abhijeet Joshi, Mario I. Vega, Stavroula Baritaki, Luigi E. Xodo, Benjamin Bonavida   +6 more
openaire   +1 more source