Results 171 to 180 of about 111,329,672 (189)

Expression, Role in Transformation and Prognostic Significance of the Transcription Factor Yin Yang 1 (YY1) in Non-Hodgkin’s Lymphoma: Analyses in NHL Tissues by Experimental and Bioinformatic Approaches

Blood, 2008
Abstract Objective and Rationale Non-Hodgkin lymphomas (NHL) are a heterogeneous group of lymphoproliferative malignancies with variable patterns of behavior and responses to treatment. Although at present a significant number of high grade lymphoma patients can be cured with intensive regimens of cytotoxic and immunotherapeutic drugs ...
LIBRA M, CASTELLANO G, BARITAKI S, HUERTA-YEPEZ S, LIGRESTI G, MILITELLO L, MALAPONTE G, STIVALA F, CANEVARI S., BONAVIDA B   +9 more
openaire   +2 more sources

Targeting the Over-Expressed Transcription Factor Yin-Yang 1 (YY1) Sensitizes Resistant Multiple Myeloma (MM) Cell Lines to Apoptosis by Bortezomib or Melphalan,

Blood, 2011
Abstract Abstract 3991 The transcription factor Yin-Yang 1 (YY1) is a multi-functional DNA-binding protein which can activate, repress, or initiate transcription depending on the context in which it binds. We have previously reported that YY1 is a repressor for the death receptors Fas and DR5 as well as it regulates both ...
Hong Liu, Sara Huerta-Yepez, Clara M. Rivera-Pazos, Ma de Lourdes Cabera-Muñoz, Stavroula Baritaki, Suzie Vardanyan, Manuel L Penichet, Haiming Chen, James R. Berenson, Benjamin Bonavida   +9 more
openaire   +1 more source

Rituximab-Mediated Inhibition of the Transcription Repressor Yin-Yang 1 (YY1) in NHL B Cell Lines: Upregulation of Fas Expression and Sensitization to Fas-Induced Apoptosis.

Blood, 2004
Abstract We have reported that rituximab triggers and inhibits anti-apoptotic gene products in NHL B-cell lines resulting in sensitization to drug-induced apoptosis (Alas et al., Clin. Cancer Res.8:836, 2001; Jazirehi et al., Mol. Cancer Therapy2:1183, 2003; Vega et al., Oncogene23:3530, 2004 ).
Mario I. Vega, Sara Huerta-Yepez, Ali R. Jazirehi, Hermes Garban, Benjamin Bonavida   +4 more
openaire   +1 more source

The Pivotal Role of Yin Yang 1 (YY1) Inhibition (and downstream Bcl-2/Bclxl) by Galiximab (anti-CD80 mAb) In the Reversal of Resistance of B-NHL Cells to Chemotherapy

Blood, 2010
Abstract Abstract 2887 Galiximab (anti-CD80 mAb) is a primatized mAb (human IgG1 constant region and Cynomogous macaque variable region) that binds CD80 on lymphoma cells. It has been shown in vitro that Galiximab inhibits tumor cell proliferation and mediates ADCC.
Melisa Martinez-Paniagua, Mario I. Vega, Sara Huerta-Yepez, Hari Hariharan, Haiming Chen, James R. Berenson, Benjamin Bonavida   +6 more
openaire   +1 more source

Abstract 664: Galiximab (anti-CD80 mAb) sensitizes TRAIL-resistant B-lymphoma to TRAIL-induced apoptosis via inhibition of the transcription repressor Yin Yang 1 (YY1)

Cancer Research, 2010
Abstract Treatment of B-lymphomas with rituximab, alone or in combination with chemotherapy, resulted in significant clinical responses and prolongation of survival. However, a significant subset relapses or does not respond to initial treatments. Therefore, there is an urgent need to identify new targets and develop therapies to reverse
Melisa A. Martinez-Paniagua, Mario I. Vega, Sara Huerta-Yepez, Hari Hariharan, Benjamin Bonavida   +4 more
openaire   +1 more source

Abstract 5450: High expression of Krüppel-Like Factor 4 (KLF4) and its regulation by Yin Yang 1 (YY1) in non-Hodgkin's B-cell lymphomas: clinical implication.

Cancer Research, 2013
Abstract Non-Hodgkin Lymphoma (NHL) is a group of different kinds of cancer rising on the basis of monoclonal expansion of B and T Lymphocytes. Over 90% of NHL has its origin in B lymphocytes. The causes of NHL are poorly understood. Diffuse large B-cell lymphoma (DLBCL), the most common lymphoma in adults, and Burkitt s lymphoma are ...
Mario I. Vega, Alberto Valencia-Hipolito, Miriam Hernandez-Atenogenes, Gabriel G. Vega, Hector Mayani, Alfonso Mendez-Tenorio, Otoniel Martinez-Maza, Sara Huerta-Yepez, Benjamin Bonavida   +8 more
openaire   +1 more source

Abstract A53: Yin Yang 1 (YY1) regulates EMT via transcriptional activation of Snail and its overexpression in cancer stem cells (CSCs) in prostate cancer: Clinical significance.

Molecular Cancer Therapeutics, 2013
Abstract The epithelial to mesenchymal transition (EMT) is a cellular program that confers on neoplastic cells the biological traits needed to accomplish the metastatic cascade. The activation of EMT has been associated with the acquisition of stem cell traits, i.e., cancer stem cells (CSCs).
Stavroula Baritaki, Valentina Rapozzi, Rosana Pelayo, Mario Vega, Sara Huerta-Yepez, Benjamin Bonavida   +5 more
openaire   +1 more source

Inverse Relationship Between the Transcription Repressor Yin Yang 1 (YY1) and the TRAIL Death Receptor DR5 in AIDS-Related Non-Hodgkin's Lymphoma Tissues: Potential Prognostic Biomarkers and Targets for Therapeutic Intervention.

Blood, 2009
Abstract Abstract 1932 Poster Board I-955 Patients infected with HIV develop AIDS-related Non-Hodgkin's lymphoma (ARL). The onset and pathogenesis of ARL has been the subject of many studies and several mechanisms have been proposed including immunosuppression (severe CD4 depletion), association with EBV ...
Sara Huerta-Yepez, Mario I. Vega, Clara Rivera-Pazos, Otoniel Martinez-Maza, James R. Berenson, Benjamin Bonavida   +5 more
openaire   +1 more source

Novel pathogenic sequence variants in Yin Yang 1 (YY1) transcription factor and abnormal DNA methylation profile

Molecular Genetics and Metabolism, 2021
Kameryn Butler, Wesley Patterson, Matthew L. Tedder, Jennifer Lee, Raymond Louie, David Genevieve, Bekim Sadikovic   +6 more
openaire   +1 more source

YY1 (Yin-Yang 1), a Transcription Factor Regulating Systemic Inflammation, Is Involved in Cognitive Impairment of Depression

Psychiatry and Clinical Neurosciences, 2023
Jing Lu, Mou tingting, Chaonan Jiang
exaly