Results 161 to 170 of about 111,329,672 (189)
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Journal of Molecular and Cellular Cardiology, 2000
Current research from both clinical and basic science perspectives indicates that cytokines play an important role in the genesis of cardiovascular pathology. Specifically, levels of cytokines such as interleukin-1 (IL-1), tumor necrosis factor- alpha (TNF- alpha), and interleukin-6 (IL-6) have been found to be elevated in both acute myocardial injury ...
M, Patten +4 more
openaire +2 more sources
Current research from both clinical and basic science perspectives indicates that cytokines play an important role in the genesis of cardiovascular pathology. Specifically, levels of cytokines such as interleukin-1 (IL-1), tumor necrosis factor- alpha (TNF- alpha), and interleukin-6 (IL-6) have been found to be elevated in both acute myocardial injury ...
M, Patten +4 more
openaire +2 more sources
Molecular Cancer Therapeutics, 2013
Abstract Krüppel-like factor 4 (KLF4) is a member of the KLF zinc-finger containing transcription factor family. Supporting evidence has established that KLF4 is either an oncogene or a tumor suppressor. Reported studies have indicated the involvement of KLF4 in the regulation of apoptosis, proliferation, and differentiation of B cells ...
Mario I. Vega +6 more
openaire +1 more source
Abstract Krüppel-like factor 4 (KLF4) is a member of the KLF zinc-finger containing transcription factor family. Supporting evidence has established that KLF4 is either an oncogene or a tumor suppressor. Reported studies have indicated the involvement of KLF4 in the regulation of apoptosis, proliferation, and differentiation of B cells ...
Mario I. Vega +6 more
openaire +1 more source
Toxicology and Applied Pharmacology, 2014
Thioacetamide (TAA) has been used to develop a rodent model for hepatocarcinogenesis. To determine the genes with epigenetic modifications in early hepatocarcinogenesis, we did a genome-wide scan for hypermethylated promoter regions using CpG island microarrays in TAA-promoted rat liver tissue. Eight genes were selected based on the microarray profile;
Hajime, Abe +7 more
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Thioacetamide (TAA) has been used to develop a rodent model for hepatocarcinogenesis. To determine the genes with epigenetic modifications in early hepatocarcinogenesis, we did a genome-wide scan for hypermethylated promoter regions using CpG island microarrays in TAA-promoted rat liver tissue. Eight genes were selected based on the microarray profile;
Hajime, Abe +7 more
openaire +2 more sources
Critical Reviews in Immunology, 2019
The transcription factor Yin Yang 1 (YY1) has been implicated in embryogenesis, cell differentiation, organ development, and regulation of T cell-mediated immune diseases. YY1 has been reported to act as an activator or repressor, or both, of various genes depending on the nature of the tissue and their context.
Feodora Roxanne, Kosasih +1 more
openaire +2 more sources
The transcription factor Yin Yang 1 (YY1) has been implicated in embryogenesis, cell differentiation, organ development, and regulation of T cell-mediated immune diseases. YY1 has been reported to act as an activator or repressor, or both, of various genes depending on the nature of the tissue and their context.
Feodora Roxanne, Kosasih +1 more
openaire +2 more sources
Blood, 2005
Abstract The transcription factor Yin Yang 1 (YY1) regulates cellular differentiation and response to apoptotic stimuli. YY1 exerts its pleiotropic effects through regulation of promoter activity of critical genes, as well as association and direct modulation of stability and function of a subset of proteins.
Benjamin Bonavida +4 more
openaire +1 more source
Abstract The transcription factor Yin Yang 1 (YY1) regulates cellular differentiation and response to apoptotic stimuli. YY1 exerts its pleiotropic effects through regulation of promoter activity of critical genes, as well as association and direct modulation of stability and function of a subset of proteins.
Benjamin Bonavida +4 more
openaire +1 more source
Blood, 2013
Abstract Krüppel-like factor 4 (KLF4) is a member of the KLF zinc-finger containing transcription factor family. Supporting evidence has established that KLF4 is either an oncogene or a tumor suppressor. Reported studies have indicated the involvement of KLF4 in the regulation of apoptosis, proliferation, and differentiation of B cells ...
Benjamin Bonavida +2 more
exaly +2 more sources
Abstract Krüppel-like factor 4 (KLF4) is a member of the KLF zinc-finger containing transcription factor family. Supporting evidence has established that KLF4 is either an oncogene or a tumor suppressor. Reported studies have indicated the involvement of KLF4 in the regulation of apoptosis, proliferation, and differentiation of B cells ...
Benjamin Bonavida +2 more
exaly +2 more sources
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2006
Histidine decarboxylase (HDC) is the enzyme that converts histidine to histamine, a bioamine that plays an important role in many physiological aspects including allergic responses, inflammation, neurotransmission, and gastric acid secretion. In previous studies, we demonstrated that Kruppel-like factor 4 represses HDC promoter activity in a gastric ...
Wandong, Ai, Ying, Liu, Timothy C, Wang
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Histidine decarboxylase (HDC) is the enzyme that converts histidine to histamine, a bioamine that plays an important role in many physiological aspects including allergic responses, inflammation, neurotransmission, and gastric acid secretion. In previous studies, we demonstrated that Kruppel-like factor 4 represses HDC promoter activity in a gastric ...
Wandong, Ai, Ying, Liu, Timothy C, Wang
openaire +2 more sources
Medical Oncology, 2023
Non-Small Cell Lung Cancer (NSCLC) is the leading cause of death in all countries alike. In the current study, we have found out that Histone H3Lys4trimethylation is abnormal on YY1 in CD4+T Helper (TH) cells of NSCLC patients which is evident by Histone H3Lys27 trimethylation mediated via EZH2.
Nikhil Chandnani +8 more
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Non-Small Cell Lung Cancer (NSCLC) is the leading cause of death in all countries alike. In the current study, we have found out that Histone H3Lys4trimethylation is abnormal on YY1 in CD4+T Helper (TH) cells of NSCLC patients which is evident by Histone H3Lys27 trimethylation mediated via EZH2.
Nikhil Chandnani +8 more
openaire +2 more sources
Critical Reviews− in Oncogenesis, 2011
The majority of cancers develop genetic and molecular strategies to resist conventional cytotoxic therapies as well as escape from the host's immune surveillance. These events lead to tumor persistence and spread through activation of the epithelial to mesenchymal transition (EMT) program and metastasis.
Benjamin, Bonavida, Stavroula, Baritaki
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The majority of cancers develop genetic and molecular strategies to resist conventional cytotoxic therapies as well as escape from the host's immune surveillance. These events lead to tumor persistence and spread through activation of the epithelial to mesenchymal transition (EMT) program and metastasis.
Benjamin, Bonavida, Stavroula, Baritaki
openaire +2 more sources
The Journal of Pathology, 2007
AbstractCD30 is a member of the TNF receptor family. Our interest lies in understanding the control of CD30 expression, particularly as its over‐expression provides a diagnostic marker for a subset of non‐Hodgkin's lymphomas, particularly anaplastic large cell lymphoma (ALCL), and because anti‐CD30 treatment has been shown to be efficacious.
M, Franchina +7 more
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AbstractCD30 is a member of the TNF receptor family. Our interest lies in understanding the control of CD30 expression, particularly as its over‐expression provides a diagnostic marker for a subset of non‐Hodgkin's lymphomas, particularly anaplastic large cell lymphoma (ALCL), and because anti‐CD30 treatment has been shown to be efficacious.
M, Franchina +7 more
openaire +2 more sources