Results 1 to 10 of about 667 (81)

Zearalenone-14-Glucoside Is Hydrolyzed to Zearalenone by β-Glucosidase in Extracellular Matrix to Exert Intracellular Toxicity in KGN Cells [PDF]

Toxins, 2022
As one of the most important conjugated mycotoxins, zearalenone-14-glucoside (Z14G) has received widespread attention from researchers. Although the metabolism of Z14G in animals has been extensively studied, the intracellular toxicity and metabolic ...
Haonan Ruan, Yunyun Wang, Yong Hou, Jing Zhang, Jiashuo Wu, Fangqing Zhang, Ming Sui, Jiaoyang Luo, Meihua Yang   +8 more
doaj   +4 more sources

Development of a reliable UHPLC-MS/MS method for simultaneous determination of zearalenone and zearalenone-14-glucoside in various feed products [PDF]

Frontiers in Chemistry, 2022
A reliable ultra-high-performance liquid chromatography–tandem mass spectrometry method (UHPLC-MS/MS) was developed for the simultaneous determination of two mycotoxins, that is, zearalenone (ZEN) and zearalenone-14-glucoside (ZEN-14G) in formula feed ...
Zhiqi Zhang, Yaling Cai, Kai Fan, Qingwen Huang, Xiuying Zhao, Haojie Cao, Zhihui Zhao, Emmanuel K. Tangni, Zheng Han   +8 more
doaj   +4 more sources

Zearalenone-14-glucoside specifically promotes dysplasia of Gut-Associated Lymphoid Tissue: A natural product for constructing intestinal nodular lymphatic hyperplasia model [PDF]

Journal of Advanced Research, 2023
Introduction: Zearalenone-14-glucoside (Z14G) is a modified mycotoxin that widely contaminates food across the world. Our preliminary experiment showed that Z14G degrades to zearalenone (ZEN) in the intestine exerting toxicity.
Haonan Ruan, Yunyun Wang, Jing Zhang, Ying Huang, Yanan Yang, Chongming Wu, Mengyue Guo, Jiaoyang Luo, Meihua Yang   +8 more
doaj   +4 more sources

Biosynthesis and Characterization of Zearalenone-14-Sulfate, Zearalenone-14-Glucoside and Zearalenone-16-Glucoside Using Common Fungal Strains [PDF]

Toxins, 2018
Zearalenone (ZEN) and its phase II sulfate and glucoside metabolites have been detected in food and feed commodities. After consumption, the conjugates can be hydrolyzed by the human intestinal microbiota leading to liberation of ZEN that implies an ...
Antje Borzekowski, Tatjana Drewitz, Julia Keller, Dietmar Pfeifer, Hans-Jörg Kunte, Matthias Koch, Sascha Rohn, Ronald Maul   +7 more
doaj   +5 more sources

Cyclodextrins Can Entrap Zearalenone-14-Glucoside: Interaction of the Masked Mycotoxin with Cyclodextrins and Cyclodextrin Bead Polymer [PDF]

Biomolecules, 2019
Zearalenone (ZEN) is a Fusarium-derived xenoestrogenic mycotoxin. In plants, zearalenone-14-O-β-d-glucoside (Z14G) is the major conjugated metabolite of ZEN, and is a masked mycotoxin.
Zelma Faisal, Eszter Fliszár-Nyúl, Luca Dellafiora, Gianni Galaverna, Chiara Dall’Asta, Beáta Lemli, Sándor Kunsági-Máté, Lajos Szente, Miklós Poór   +8 more
doaj   +6 more sources

Interactions of zearalanone, α-zearalanol, β-zearalanol, zearalenone-14-sulfate, and zearalenone-14-glucoside with serum albumin. [PDF]

Mycotoxin Res, 2020
AbstractThe xenoestrogenic mycotoxin zearalenone is a Fusarium-derived food and feed contaminant. In mammals, the reduced (e.g., zearalanone, α-zearalanol, and β-zearalanol) and conjugated (e.g., zearalenone-14-sulfate) metabolites of zearalenone are formed.
Faisal Z, Vörös V, Fliszár-Nyúl E, Lemli B, Kunsági-Máté S, Poór M.   +5 more
europepmc   +7 more sources

Kinetics and Distribution of Zearalenone-14-Glucoside and Its Metabolite Zearalenone in Rat, Determined by a Reliable HPLC-MS/MS Method

Applied Sciences, 2023
A reliable high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was established for the simultaneous detection of zearalenone-14-glucoside (ZEN-14G) and its metabolite, zearalenone (ZEN), in the plasma, urine, and various ...
Yaling Cai, Zhiqi Zhang, Fang Dong, Zefeng Ma, Kai Fan, Zheng Han, Zhizhong Li, Zhihui Zhao   +7 more
doaj   +2 more sources

Further insight into the potential toxicity of zearalenone-14-glucoside based on toxicokinetics, tissue distribution, transformation, and excretion in rats

Ecotoxicology and Environmental Safety, 2022
Bioaccumulation and biotransformation are critical factors that affect the release of easily metabolizable chemicals to cause human toxicity. The glucoside-type modified mycotoxin Zearalenone-14-Glucoside (Z14G) has attracted global attention for its ...
Qian Lu, Ming Sui, Ya-Wen Luo, Jiao-Yang Luo, Mei-Hua Yang   +4 more
doaj   +3 more sources

Metabolic Profile, Bioavailability and Toxicokinetics of Zearalenone-14-Glucoside in Rats after Oral and Intravenous Administration by Liquid Chromatography High-Resolution Mass Spectrometry and Tandem Mass Spectrometry. [PDF]

Int J Mol Sci, 2019
Zearalenone-14-glucoside (ZEN-14G), a key modified mycotoxin, has attracted a great deal of attention due to the possible conversion to its free form of zearalenone (ZEN) exerting toxicity. In this study, the toxicokinetics of ZEN-14G were investigated in rats after oral and intravenous administration. The plasma concentrations of ZEN-14G and its major
Sun F, Tan H, Li Y, De Boevre M, De Saeger S, Zhou J, Li Y, Rao Z, Yang S, Zhang H.   +9 more
europepmc   +5 more sources

Probing Serum Albumins and Cyclodextrins as Binders of the Mycotoxin Metabolites Alternariol-3-Glucoside, Alternariol-9-Monomethylether-3-Glucoside, and Zearalenone-14-Glucuronide [PDF]

Metabolites, 2023
Mycotoxins are toxic metabolites of molds. Chronic exposure to alternariol, zearalenone, and their metabolites may cause the development of endocrine-disrupting and carcinogenic effects.
Miklós Poór, Beáta Lemli, Péter Vilmányi, Ágnes Dombi, Zoltán Nagymihály, Eszter Borbála Both, Nándor Lambert, Tamás Czömpöly, Lajos Szente   +8 more
doaj   +2 more sources