Results 1 to 10 of about 43,067 (192)
A rare case report of severe aplastic anaemia caused by long-term use of zidovudine [PDF]
BMC Infectious DiseasesBackground Zidovudine is an antiviral drug used to treat acquired immune deficiency syndrome (AIDS). Anaemia is a common adverse effect of zidovudine that usually occurs in the first 2 to 4 weeks of initial treatment. Here, we describe a patient with HIV
Jing Zhou +6 more
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Pharmaceutics, 2022 Nucleos(t)ide reverse transcriptase inhibitors (NRTIs) are the backbone of HIV antiretroviral therapy (ART). ART use in pregnancy has been associated with adverse birth outcomes, in part due to NRTI-induced mitochondrial toxicity.
Kayode Balogun, Lena Serghides
doaj +1 more source
Liver Fibrosis during Antiretroviral Treatment in HIV-Infected Individuals. Truth or Tale?
Cells, 2021 After the introduction of antiretroviral treatment (ART) back in 1996, the lifespan of people living with HIV (PLWH) has been substantially increased, while the major causes of morbidity and mortality have switched from opportunistic infections and AIDS ...
Athanasios-Dimitrios Bakasis +1 more
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The Use of Zidovudine Pharmacophore in Multi-Target-Directed Ligands for AIDS Therapy
Molecules, 2022 The concept of polypharmacology embraces multiple drugs combined in a therapeutic regimen (drug combination or cocktail), fixed dose combinations (FDCs), and a single drug that binds to different targets (multi-target drug).
Maria da Conceição Avelino Dias Bianco +6 more
doaj +1 more source
Infectious Diseases in Obstetrics and Gynecology, 1998 Zidovudine was the first agent approved for treatment of HIV disease, and since its widespread availability in 1987, the pharmacokinetic disposition and clinical effects of ZDV have been extensively evaluated. In addition to its utility as a component of a multidrug combination regimen for the treatment of adult and pediatric HIV-1 infection, it is the
openaire +3 more sources
Post Exposure Prophylaxis for Occupational Exposures to HIV and Hepatitis B: Our Experience of Thirteen Years at a Rural Based Tertiary Care Teaching Hospital of Western India [PDF]
Journal of Clinical and Diagnostic Research, 2016 Introduction: Health Care Workers (HCWs) are at risk of occupational transmission of HIV, Hepatitis B and Hepatitis C, which can be minimized by following guidelines for standard precautions as well as taking Post Exposure Prophylaxis (PEP) measures.
Sanket Pranjivan Sheth +2 more
doaj +1 more source
Microbicides development programme: engaging the community in the standard of care debate in a vaginal microbicide trial in Mwanza, Tanzania. [PDF]
, 2009 BACKGROUND: HIV prevention research in resource-limited countries is associated with a variety of ethical dilemmas. Key amongst these is the question of what constitutes an appropriate standard of health care (SoC) for participants in HIV prevention ...
Changalucha, John +11 more
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Implementing a tenofovir-based first-line regimen in rural Lesotho: clinical outcomes and toxicities after two years. [PDF]
, 2011 The latest World Health Organization guidelines recommend replacing stavudine with tenofovir or zidovudine in first-line antiretroviral therapy in resource-limited settings.
Birkus +12 more
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Frontiers in Microbiology, 2022 Avian leukosis virus (ALV) causes tumor diseases in poultry and is circulating all over the world, leading to significant economic losses. In addition, mixed infection of ALV with other viruses is very common and is often reported to contaminate live ...
Qun Wang +29 more
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