Results 41 to 50 of about 43,067 (192)

Top-Down Synthesis of a Lamivudine-Zidovudine Nano Co-Crystal

Crystals, 2020
Lamivudine (3TC) and zidovudine (AZT) are antiretroviral agents used to manage HIV/AIDS infection. A wet media milling top-down approach was used to develop and produce nano co-crystals of 3TC and AZT.
Bwalya A. Witika, Vincent J. Smith, Roderick B. Walker   +2 more
doaj   +1 more source

Analysis of in vitro and in vivo metabolism of zidovudine and gemfibrozil in trans‐chromosomic mouse line expressing human UGT2 enzymes

Pharmacology Research & Perspectives, 2022
UDP‐glucuronosyltransferases (UGTs) catalyze the conjugation of various substrates with sugars. Since the UGT2 family forms a large cluster spanning 1.5 Mb, transgenic mouse lines carrying the entire human UGT2 family have not been constructed because of
Kaoru Kobayashi, Tsuneo Deguchi, Satoshi Abe, Naoyo Kajitani, Kanako Kazuki, Shoko Takehara, Kazuomi Nakamura, Atsushi Kurihara, Mitsuo Oshimura, Yasuhiro Kazuki   +9 more
doaj   +1 more source

Effect of HIV infection and antiretroviral therapy on hepatitis B virus (HBV)-specific T cell responses in patients who have resolved HBV infection [PDF]

, 2005
Coinfection with hepatitis B virus (HBV) is a common occurrence in human immunodeficiency virus (HIV)–positive patients and an increasing cause of morbidity and mortality.
Bertoletti, A., Copas, A., Dunn, C., Gilson, R.J., Johnstone, R., Lascar, R.M., Lopes, A.R., Maini, M.K., Reignat, S., Webster, G.   +9 more
core   +1 more source

Engaging the public in plant science: Communication facilitators and barriers of scaling up a citizen science campaign

People and Nature, EarlyView.
Abstract Volunteers have been involved in nature observations for decades through citizen science initiatives, providing large data sets as well as problem identification that allow a more complete understanding of many natural phenomena. Although communication is a core component in citizen science, the key factors that determine its effectiveness in ...
Kristiina Gibson, Monika Suškevičs, Baiba Prūse, Marta Barberis, Sara A. O. Cousins, Živa Fišer, Margaux Julien, Marianne Kivastik, Marcin Klisz, Attila Lengyel, Zuzana Münzbergová, Radosław Puchałka, Iris Reinula, Froukje Rienks, Julie Koch Sheard, Viktor Siverin, Bojana Stojanova, Sabrina Träger, Tsipe Aavik   +18 more
wiley   +1 more source

AZT exerts its antitumoral effect by telomeric and non-telomeric effects in a mammary adenocarcinoma model [PDF]

, 2016
Limitless replicative potential is one of the hallmarks of cancer that is mainly due to the activity of telomerase. This holoenzyme maintains telomere length, adding TTAGGG repetitions at the end of chromosomes in each cell division.
Armando, Romina Gabriela, Gomez, Daniel Eduardo, Gomez, Daniel Eduardo   +2 more
core   +1 more source

Cell-free (RNA) and cell-associated (DNA) HIV-1 and postnatal transmission through breastfeeding [PDF]

, 2012
<p>Introduction - Transmission through breastfeeding remains important for mother-to-child transmission (MTCT) in resource-limited settings. We quantify the relationship between cell-free (RNA) and cell-associated (DNA) shedding of HIV-1 virus in ...
A Antinori, A Ayouba, A Gupta, AJ Ruff, AS Goldman, BA Richardson, C Bennetto-Hood, C Kilewo, CL Townsend, Claire Thorne, CM Rousseau, CM Rousseau, CS Chasela, D Chege, D Neveu, D Valea, DA Lehman, ER Cooper, F Rouet, FA Mmiro, G John-Stewart, GC John, HM Coovadia, I de Vincenzi, IN Koulinska, JA Slyker, James Ndirangu, JF Willumsen, Johannes Viljoen, K Pillay, K Semrau, L Houzet, LA Guay, Landon Myer, Marie-Louise Newell, MH Chung, MH Chung, MH Chung, MK Ghosh, ML Newell, P Becquart, P Lewis, P Van de Perre, P Van de Perre, Philippe Van de Perre, R Bland, RD Semba, RL Shapiro, RL Shapiro, RM Bland, Ruth M. Bland, RW Nduati, S Cassol, S Gantt, S Tasker, Siva Danaviah, Study European Collaborative, Study European Collaborative, TK Thomas, W Khamduang   +59 more
core   +8 more sources

Towards epistemic and linguistic justice in universities: Exploring the Australian university linguascene from student perspectives

International Journal of Applied Linguistics, EarlyView.
Abstract This paper addresses linguistic and epistemic justice by exploring multilingual practices in tertiary contexts in an English‐dominant linguistic ecology. The paper argues that the university linguistic space (linguascene) governs language choices toward English monolingualism, and this has implications for epistemic justice in multilingual ...
Anikó Hatoss, Eliot Allport
wiley   +1 more source

The Ethics of Placebo-controlled Trials: Methodological Justifications [PDF]

, 2013
The use of placebo controls in clinical trials remains controversial. Ethical analysis and international ethical guidance permit the use of placebo controls in randomized trials when scientifically indicated in four cases: (1) when there is no proven ...
Grady, Christine, Millum, Joseph
core   +1 more source

Sensitivity analysis for generalized estimating equation with non‐ignorable missing data

Scandinavian Journal of Statistics, EarlyView.
Abstract Many incomplete‐data statistical inference procedures are developed under the missing at random (MAR) assumption. However, the MAR assumption has been criticized as being overly strong for real‐data problems, and is unverifiable by using observed data. To handle data that are missing not at random (MNAR), sensitivity analysis has been proposed
Hui Gong, Kin Wai Chan
wiley   +1 more source

HIV/AIDS treatment and physicochemical quality control of medicines: evaluation of non-generic lamivudine + zidovudine tablets manufactured in Brazil

Brazilian Journal of Infectious Diseases
In this work it was evaluated the physicochemical quality of lamivudine + zidovudine tablets, whose association belongs to the list of drugs distributed by the Brazil's National Program on Sexually Transmitted Diseases and AIDS. Four non-generic products
Ruy Carlos Ruver Beck, Margareth Linde Athayde, Simone Gonçalves Cardoso   +2 more
doaj   +1 more source