Results 1 to 10 of about 59,632 (91)

Expression of Claudin-9 (CLDN9) in Breast Cancer, the Clinical Significance in Connection with Its Subcoat Anchorage Proteins ZO-1 and ZO-3 and Impact on Drug Resistance [PDF]

Biomedicines, 2023
(1) Introduction: Claudin-9 (CLDN9) is a member of the claudin protein family, a critical transmembrane protein family for tight junctions that are implemented in the progression of numerous cancer types.
Xinguo Zhuang, Tracey A. Martin, Fiona Ruge, Jianyuan (Jimmy) Zeng, Xinyu (Amber) Li, Elyas Khan, Qingping Dou, Eleri Davies, Wen G. Jiang   +8 more
doaj   +2 more sources

Context-dependent interactions among afadin, ZO-1, and actin filaments [PDF]

Cell Structure and Function
Afadin and ZO-1 are actin-binding scaffold proteins localized at cell-cell junctions. Although these proteins contain multiple protein-binding motifs for various junctional proteins, their binding partners within cells are strictly regulated.
Yuji Nitta, Satoshi Urayama, Maki Kawashima, Hayato Nakao, Takafumi Ikeda, Kazushi Higashiyama, Hatsuki Murakami, Chiyoko Kobayashi, Yuichiro Kano, Mikio Furuse, Akira Nagafuchi   +10 more
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ZO-1/Tjp1 and ZO-2/Tjp2 deletion in retinal pigment epithelium causes progressive retinal degeneration [PDF]

iScience
Summary: Tight junction protein-1 and -2 (Tjp1/ZO-1 and Tjp2/ZO-2) function as scaffold proteins within the tight junction complexes of the blood-retinal barrier (BRB). Although the breakdown of the BRB is implicated in retinopathies, the contribution of
Safiah Mohamed Ali, Bhav Harshad Parikh, Queenie Shu Woon Tan, Barbara Hübner, Aleksandra N. Kozyrina, Animesh Banerjee, Jie Zhao, Debbie Goh, Hanumakumar Bogireddi, Sia Wey Yeo, Daniel Soo Lin Wong, Jianliang Xu, Kim Chi Tran, Zengping Liu, Yun-Zheng Le, Veluchamy Amutha Barathi, Kang Hao Cheong, Jacopo Di Russo, Alexander Ludwig, Walter Hunziker, Xinyi Su   +20 more
doaj   +2 more sources

Molecular alterations associated with pathophysiology in liver-specific ZO-1 and ZO-2 knockout mice [PDF]

Cell Structure and Function
The liver is a complex organ with a highly organized structure in which tight junctions (TJs) play an important role in maintaining their function by regulating barrier properties and cellular polarity.
Masahiko Itoh, Kenji Watanabe, Yoichi Mizukami, Hiroyuki Sugimoto   +3 more
doaj   +2 more sources

ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis [PDF]

Nature Communications
Zonula occludens-1 (ZO-1) is involved in the regulation of cell-cell junctions between endothelial cells (ECs). Here we identify the ZO-1 protein interactome and uncover ZO-1 interactions with RNA-binding proteins that are part of stress granules (SGs ...
Yassine El Bakkouri, Rony Chidiac, Chantal Delisle, Jeanne Corriveau, Gael Cagnone, Vanda Gaonac’h-Lovejoy, Ashley Chin, Éric Lécuyer, Stephane Angers, Jean-Sébastien Joyal, Ivan Topisirovic, Laura Hulea, Alexandre Dubrac, Jean-Philippe Gratton   +13 more
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ZO-1 Regulates Hippo-Independent YAP Activity and Cell Proliferation via a GEF-H1- and TBK1-Regulated Signalling Network [PDF]

Cells
Tight junctions are a barrier-forming cell–cell adhesion complex and have been proposed to regulate cell proliferation. However, the underlying mechanisms are not well understood.
Alexis J. Haas, Mert Karakus, Ceniz Zihni, Maria S. Balda, Karl Matter   +4 more
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miRNA-328-3p regulates ZO-1 expression and inhibits PEDV proliferation via the PLC-β1-PKC pathway. [PDF]

PLoS ONE
Porcine epidemic diarrhea virus (PEDV) is a significant pathogen affecting swine, causing severe economic losses worldwide. This study explores the regulatory role of miRNA-328-3p to ZO-1 expression and its impact on PEDV proliferation via the PLC-β1-PKC
Han Zhao, Jiayu Zhang, Dengliang Li, Zhanding Cui, Jiuyuan Liu, Di Bao, Yiming Wei, Xinyue Zhang, Zhimin Wu, Tianqi Zhang, Kai Wang, Shushuai Yi, Wei Lian, Guixue Hu   +13 more
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N-acetylglucosaminyltransferase V drives colorectal cancer metastasis by facilitating ZO-1 ubiquitination and degradation [PDF]

Cancer Cell International
Increasing evidence supports the crucial role of Epithelial-Mesenchymal Transition (EMT) in cancer invasion and metastasis. N-acetylglucosaminyltransferase V (MGAT5), which is associated with multiantenna glycosylation, can contribute to tumorigenesis ...
Yueping Zhan, Chenjun Huang, Rong Wang, Xiao Xiao, Xuewen Xu, Chunfang Gao   +5 more
doaj   +2 more sources

PEAK1 maintains tight junctions in intestinal epithelial cells and resists colitis by inhibiting autophagy-mediated ZO-1 degradation [PDF]

Nature Communications
Tight junctions are crucial for maintaining intestinal barrier homeostasis, but how organisms modulate these junctions remain unclear. Here, we show a role for PEAK1 at cell-cell contact sites, where it interacts with ZO-1 via a conserved region spanning
Zaikuan Zhang, Yajun Xie, Qiying Yi, Jianing Liu, Lin Yang, Runzhi Wang, Jing Cai, Xinyi Li, Xiaosong Feng, Shixiang Yao, Zheng Pan, Magdalena Paolino, Qin Zhou   +12 more
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Dynamic changes of inducible nitric oxide synthase expression in rat’s retina and its role on blood-retinal barrier injury after acute high intraocular pressure [PDF]

International Journal of Ophthalmology, 2022
AIM: To clarify the role of inducible nitric oxide synthase (iNOS) in blood-retinal barrier (BRB) injury after acute high intraocular pressure (IOP) in rats. METHODS: Forty-two Sprague-Dawley (SD) rats were randomized into 7 groups [control (Cont), 3, 6,
Min Li, Ju-Fang Huang, Yi Li, Jing Shen, Lu-Jia Yang, Qian Chen, Quan-Peng Zhang, Xi-Nan Yi   +7 more
doaj   +1 more source