Results 1 to 10 of about 91,984 (280)

Tight junction protein ZO-1 in Kawasaki disease [PDF]

BMC Pediatrics, 2021
Background Kawasaki disease (KD) is a form of systemic febrile vasculitis that is complicated with coronary artery lesions (CAL). The tight junctions that maintain the intestinal barrier also play a role in systemic inflammatory diseases.
Wan-Tz Lai, Hung-Chang Lee, Ying-Hsien Huang, Mao-Hung Lo, Ho-Chang Kuo   +4 more
doaj   +3 more sources

Expression of Claudin-9 (CLDN9) in Breast Cancer, the Clinical Significance in Connection with Its Subcoat Anchorage Proteins ZO-1 and ZO-3 and Impact on Drug Resistance [PDF]

Biomedicines, 2023
(1) Introduction: Claudin-9 (CLDN9) is a member of the claudin protein family, a critical transmembrane protein family for tight junctions that are implemented in the progression of numerous cancer types.
Xinguo Zhuang, Tracey A. Martin, Fiona Ruge, Jianyuan (Jimmy) Zeng, Xinyu (Amber) Li, Elyas Khan, Qingping Dou, Eleri Davies, Wen G. Jiang   +8 more
doaj   +2 more sources

ZO-1 knockout by TALEN-mediated gene targeting in MDCK cells: involvement of ZO-1 in the regulation of cytoskeleton and cell shape. [PDF]

PLoS ONE, 2014
ZO-1, ZO-2 and ZO-3 are tight junction-associated scaffold proteins that bind to transmembrane proteins of tight junctions and the underlying cytoskeleton.
Shinsaku Tokuda, Tomohito Higashi, Mikio Furuse   +2 more
doaj   +4 more sources

CHILKBP protects against podocyte injury by preserving ZO-1 expression. [PDF]

Cell Mol Life Sci, 2022
Glomerular diseases afflict millions of people and impose an enormous burden on public healthcare costs worldwide. Identification of potential therapeutic targets for preventing glomerular diseases is of considerable clinical importance. CHILKBP is a focal adhesion protein and modulates a wide array of biological functions.
Guo C, Ding Y, Yang A, Geng Y, Liu C, Zhou L, Ma L, Yang Z, Hu F, Jiang K, Cai R, Bai P, Quan M, Deng Y, Wu C, Sun Y.   +15 more
europepmc   +3 more sources

ZO-1/Tjp1 and ZO-2/Tjp2 deletion in retinal pigment epithelium causes progressive retinal degeneration [PDF]

iScience
Summary: Tight junction protein-1 and -2 (Tjp1/ZO-1 and Tjp2/ZO-2) function as scaffold proteins within the tight junction complexes of the blood-retinal barrier (BRB). Although the breakdown of the BRB is implicated in retinopathies, the contribution of
Safiah Mohamed Ali, Bhav Harshad Parikh, Queenie Shu Woon Tan, Barbara Hübner, Aleksandra N. Kozyrina, Animesh Banerjee, Jie Zhao, Debbie Goh, Hanumakumar Bogireddi, Sia Wey Yeo, Daniel Soo Lin Wong, Jianliang Xu, Kim Chi Tran, Zengping Liu, Yun-Zheng Le, Veluchamy Amutha Barathi, Kang Hao Cheong, Jacopo Di Russo, Alexander Ludwig, Walter Hunziker, Xinyi Su   +20 more
doaj   +2 more sources

Molecular alterations associated with pathophysiology in liver-specific ZO-1 and ZO-2 knockout mice [PDF]

Cell Structure and Function
The liver is a complex organ with a highly organized structure in which tight junctions (TJs) play an important role in maintaining their function by regulating barrier properties and cellular polarity.
Masahiko Itoh, Kenji Watanabe, Yoichi Mizukami, Hiroyuki Sugimoto   +3 more
doaj   +2 more sources

ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis [PDF]

Nature Communications
Zonula occludens-1 (ZO-1) is involved in the regulation of cell-cell junctions between endothelial cells (ECs). Here we identify the ZO-1 protein interactome and uncover ZO-1 interactions with RNA-binding proteins that are part of stress granules (SGs ...
Yassine El Bakkouri, Rony Chidiac, Chantal Delisle, Jeanne Corriveau, Gael Cagnone, Vanda Gaonac’h-Lovejoy, Ashley Chin, Éric Lécuyer, Stephane Angers, Jean-Sébastien Joyal, Ivan Topisirovic, Laura Hulea, Alexandre Dubrac, Jean-Philippe Gratton   +13 more
doaj   +2 more sources

ZO-1 Regulates Hippo-Independent YAP Activity and Cell Proliferation via a GEF-H1- and TBK1-Regulated Signalling Network [PDF]

Cells
Tight junctions are a barrier-forming cell–cell adhesion complex and have been proposed to regulate cell proliferation. However, the underlying mechanisms are not well understood.
Alexis J. Haas, Mert Karakus, Ceniz Zihni, Maria S. Balda, Karl Matter   +4 more
doaj   +2 more sources

miRNA-328-3p regulates ZO-1 expression and inhibits PEDV proliferation via the PLC-β1-PKC pathway. [PDF]

PLoS ONE
Porcine epidemic diarrhea virus (PEDV) is a significant pathogen affecting swine, causing severe economic losses worldwide. This study explores the regulatory role of miRNA-328-3p to ZO-1 expression and its impact on PEDV proliferation via the PLC-β1-PKC
Han Zhao, Jiayu Zhang, Dengliang Li, Zhanding Cui, Jiuyuan Liu, Di Bao, Yiming Wei, Xinyue Zhang, Zhimin Wu, Tianqi Zhang, Kai Wang, Shushuai Yi, Wei Lian, Guixue Hu   +13 more
doaj   +2 more sources

N-acetylglucosaminyltransferase V drives colorectal cancer metastasis by facilitating ZO-1 ubiquitination and degradation [PDF]

Cancer Cell International
Increasing evidence supports the crucial role of Epithelial-Mesenchymal Transition (EMT) in cancer invasion and metastasis. N-acetylglucosaminyltransferase V (MGAT5), which is associated with multiantenna glycosylation, can contribute to tumorigenesis ...
Yueping Zhan, Chenjun Huang, Rong Wang, Xiao Xiao, Xuewen Xu, Chunfang Gao   +5 more
doaj   +2 more sources