Results 11 to 20 of about 59,731 (190)

Filtered Kombucha tea ameliorates the leaky gut syndrome in young and old mice model of colitis [PDF]

Iranian Journal of Basic Medical Sciences, 2019
Objective(s): Zonula occludens proteins (ZO-1 and ZO-2) are important intracellular tight junction (TJ)-associated proteins that link the cell cytoskeleton to the trans-membrane TJ proteins.
Nafiseh Pakravan, Fatemeh Kkermanian, Elaheh Mahmoudi   +2 more
doaj   +1 more source

Zonula occludens-1 expression is reduced in nasal epithelial cells of allergic rhinitis patients [PDF]

PeerJ, 2022
Allergic rhinitis (AR) is a common allergic disease characterized by disruption of nasal epithelial barrier. In this study, we investigated the mRNA expression of zonula occludens-1 (ZO-1), ZO-2 and ZO-3 and histone deacetylase 1 (HDAC1) and HDAC2 in AR ...
Che Othman Siti Sarah, Siti Muhamad Nur Husna, Norasnieda Md. Shukri, Kah Keng Wong, Noor Suryani Mohd Ashari   +4 more
doaj   +2 more sources

Dexmedetomidine may decrease the bupivacaine toxicity to heart

Open Medicine, 2021
The purpose of our study was to explore the effect of dexmedetomidine on cardiac tolerance to bupivacaine.
Jin Zhousheng, Xia Fangfang, Lin Tingting, Cai Yaoyao, Chen Hongfei, Wang Yuelan   +5 more
doaj   +1 more source

STAT1/MUC4 activation promotes antimicrobial peptide production to reduce intestinal epithelium barrier injury caused by enteropathogenic Escherichia coli infection

Archives of Medical Science, 2023
Introduction Antimicrobial peptides (AMPs) are endogenous peptides that have been identified to alleviate intestinal epithelial barrier inflammation and dysfunction caused by enteropathogenic Escherichia coli (EPEC) infection; nonetheless, the upstream ...
Liu Pei, Zhigang Zuo, Meixiang Zhang, Likun Zhao, Kaishuang Li   +4 more
doaj   +1 more source

The Drosophila ZO-1 protein Polychaetoid suppresses Deltex-regulated Notch activity to modulate germline stem cell niche formation [PDF]

Open Biology, 2017
The developmental signalling protein Notch can be proteolytically activated following ligand-interaction at the cell surface, or can be activated independently of its ligands, following Deltex (Dx)-induced Notch endocytosis and trafficking to the ...
Hideyuki Shimizu, Marian B. Wilkin, Simon A. Woodcock, Alessandro Bonfini, Yvonne Hung, Sabine Mazaleyrat, Martin Baron   +6 more
doaj   +1 more source

Quercetin effectively improves LPS-induced intestinal inflammation, pyroptosis, and disruption of the barrier function through the TLR4/NF-κB/NLRP3 signaling pathway in vivo and in vitro

Food & Nutrition Research, 2022
Background: Inflammatory bowel diseases are characterized by the alterations of the mucosa and gastrointestinal physiology, and the core of these alterations is endothelial cells.
Hui-Xin Zhang, Ye-Ye Li, Zhong-Jie Liu, Jiu-Feng Wang   +3 more
doaj   +1 more source

Altered Expression of Zonula occludens-1 Affects Cardiac Na⁺ Channels and Increases Susceptibility to Ventricular Arrhythmias

Cells, 2022
Zonula occludens-1 (ZO-1) is an intracellular scaffolding protein that orchestrates the anchoring of membrane proteins to the cytoskeleton in epithelial and specialized tissue including the heart.
Mona El Refaey, Sara Coles, Hassan Musa, Tyler L. Stevens, Michael J. Wallace, Nathaniel P. Murphy, Steve Antwi-Boasiako, Lindsay J. Young, Heather R. Manring, Jerry Curran, Michael A. Makara, Kelli Sas, Mei Han, Sara N. Koenig, Michel Skaf, Crystal F. Kline, Paul M. L. Janssen, Federica Accornero, Maegen A. Borzok, Peter J. Mohler   +19 more
doaj   +1 more source

Yes-Associated Protein Is Required for ZO-1-Mediated Tight-Junction Integrity and Cell Migration in E-Cadherin-Restored AGS Gastric Cancer Cells

Biomedicines, 2021
Yes-associated protein (YAP) regulates numerous cellular homeostasis processes and malignant transformation. We found that YAP influences ZO-1-mediated cell migration using E-cadherin-restored EC96 cells derived from gastric malignant AGS cells.
Seon-Young Kim, Song-Yi Park, Hwan-Seok Jang, Yong-Doo Park, Sun-Ho Kee   +4 more
doaj   +1 more source

Syncytiotrophoblast of Placentae from Women with Zika Virus Infection Has Altered Tight Junction Protein Expression and Increased Paracellular Permeability

Cells, 2019
The cytotrophoblast of human placenta transitions into an outer multinucleated syncytiotrophoblast (STB) layer that covers chorionic villi which are in contact with maternal blood in the intervillous space. During pregnancy, the Zika virus (ZIKV) poses a
Jael Miranda, Dolores Martín-Tapia, Yolotzin Valdespino-Vázquez, Lourdes Alarcón, Aurora Espejel-Nuñez, Mario Guzmán-Huerta, José Esteban Muñoz-Medina, Mineko Shibayama, Bibiana Chávez-Munguía, Guadalupe Estrada-Gutiérrez, Samuel Lievano, Juan Ernesto Ludert, Lorenza González-Mariscal   +12 more
doaj   +1 more source

Tight junction protein ZO-1 in Kawasaki disease

BMC Pediatrics, 2021
Background Kawasaki disease (KD) is a form of systemic febrile vasculitis that is complicated with coronary artery lesions (CAL). The tight junctions that maintain the intestinal barrier also play a role in systemic inflammatory diseases.
Wan-Tz Lai, Hung-Chang Lee, Ying-Hsien Huang, Mao-Hung Lo, Ho-Chang Kuo   +4 more
doaj   +1 more source