PEAK1 maintains tight junctions in intestinal epithelial cells and resists colitis by inhibiting autophagy-mediated ZO-1 degradation [PDF]
Nature CommunicationsTight junctions are crucial for maintaining intestinal barrier homeostasis, but how organisms modulate these junctions remain unclear. Here, we show a role for PEAK1 at cell-cell contact sites, where it interacts with ZO-1 via a conserved region spanning
Zaikuan Zhang +12 more
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Context-dependent interactions among afadin, ZO-1, and actin filaments
Cell Structure and FunctionAfadin and ZO-1 are actin-binding scaffold proteins localized at cell-cell junctions. Although these proteins contain multiple protein-binding motifs for various junctional proteins, their binding partners within cells are strictly regulated.
Yuji Nitta +10 more
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Boswellia serrata Preserves Intestinal Epithelial Barrier from Oxidative and Inflammatory Damage [PDF]
, 2015 Aminosalicylates, corticosteroids and immunosuppressants are currently the therapeutic choices in inflammatory bowel diseases (IBD), however, with limited remission and often serious side effects.
Brun, Paola +10 more
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Dynamic changes of inducible nitric oxide synthase expression in rat’s retina and its role on blood-retinal barrier injury after acute high intraocular pressure [PDF]
International Journal of Ophthalmology, 2022 AIM: To clarify the role of inducible nitric oxide synthase (iNOS) in blood-retinal barrier (BRB) injury after acute high intraocular pressure (IOP) in rats. METHODS: Forty-two Sprague-Dawley (SD) rats were randomized into 7 groups [control (Cont), 3, 6,
Min Li +7 more
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Zonula occludens-1 expression is reduced in nasal epithelial cells of allergic rhinitis patients [PDF]
PeerJ, 2022 Allergic rhinitis (AR) is a common allergic disease characterized by disruption of nasal epithelial barrier. In this study, we investigated the mRNA expression of zonula occludens-1 (ZO-1), ZO-2 and ZO-3 and histone deacetylase 1 (HDAC1) and HDAC2 in AR ...
Che Othman Siti Sarah +4 more
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Filtered Kombucha tea ameliorates the leaky gut syndrome in young and old mice model of colitis [PDF]
Iranian Journal of Basic Medical Sciences, 2019 Objective(s): Zonula occludens proteins (ZO-1 and ZO-2) are important intracellular tight junction (TJ)-associated proteins that link the cell cytoskeleton to the trans-membrane TJ proteins.
Nafiseh Pakravan +2 more
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Dexmedetomidine may decrease the bupivacaine toxicity to heart
Open Medicine, 2021 The purpose of our study was to explore the effect of dexmedetomidine on cardiac tolerance to bupivacaine.
Jin Zhousheng +5 more
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The Drosophila ZO-1 protein Polychaetoid suppresses Deltex-regulated Notch activity to modulate germline stem cell niche formation [PDF]
Open Biology, 2017 The developmental signalling protein Notch can be proteolytically activated following ligand-interaction at the cell surface, or can be activated independently of its ligands, following Deltex (Dx)-induced Notch endocytosis and trafficking to the ...
Hideyuki Shimizu +6 more
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Archives of Medical Science, 2023 Introduction Antimicrobial peptides (AMPs) are endogenous peptides that have been identified to alleviate intestinal epithelial barrier inflammation and dysfunction caused by enteropathogenic Escherichia coli (EPEC) infection; nonetheless, the upstream ...
Liu Pei +4 more
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R40.76 binds to the α domain of ZO-1: role of ZO-1 (α+) in epithelial differentiation and mechano-sensing [PDF]
Tissue Barriers, 2019 The barrier function of epithelia and endothelia depends on tight junctions, which are formed by the polymerization of claudins on a scaffold of ZO proteins. Two differentially spliced isoforms of ZO-1 have been described, depending on the presence of the α domain, but the function of this domain is unclear.
Rouaud, Florian +4 more
openaire +3 more sources