Results 21 to 30 of about 91,984 (280)

ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction [PDF]

Circulation Research, 2020
Rationale: ZO-1 (Zona occludens 1), encoded by the tight junction protein 1 ( TJP1 ) gene, is a regulator of paracellular permeability in epithelia and endothelia. ZO-1 interacts with the actin cytoskeleton, gap, and adherens junction proteins and localizes to intercalated discs in ...
Wenli Dai, Rangarajan D. Nadadur, Jaclyn A. Brennan, Heather L. Smith, Kaitlyn M. Shen, Margaret Gadek, Brigitte Laforest, Mingyi Wang, Joanna Gemel, Ye Li, Jing Zhang, Bruce D. Ziman, Jiajie Yan, Xun Ai, Eric C. Beyer, Edward G. Lakata, Narayanan Kasthuri, Igor R. Efimov, Michael T. Broman, Ivan P. Moskowitz, Le Shen, Christopher R. Weber   +21 more
openaire   +2 more sources

Quercetin effectively improves LPS-induced intestinal inflammation, pyroptosis, and disruption of the barrier function through the TLR4/NF-κB/NLRP3 signaling pathway in vivo and in vitro

Food & Nutrition Research, 2022
Background: Inflammatory bowel diseases are characterized by the alterations of the mucosa and gastrointestinal physiology, and the core of these alterations is endothelial cells.
Hui-Xin Zhang, Ye-Ye Li, Zhong-Jie Liu, Jiu-Feng Wang   +3 more
doaj   +1 more source

Altered Expression of Zonula occludens-1 Affects Cardiac Na⁺ Channels and Increases Susceptibility to Ventricular Arrhythmias

Cells, 2022
Zonula occludens-1 (ZO-1) is an intracellular scaffolding protein that orchestrates the anchoring of membrane proteins to the cytoskeleton in epithelial and specialized tissue including the heart.
Mona El Refaey, Sara Coles, Hassan Musa, Tyler L. Stevens, Michael J. Wallace, Nathaniel P. Murphy, Steve Antwi-Boasiako, Lindsay J. Young, Heather R. Manring, Jerry Curran, Michael A. Makara, Kelli Sas, Mei Han, Sara N. Koenig, Michel Skaf, Crystal F. Kline, Paul M. L. Janssen, Federica Accornero, Maegen A. Borzok, Peter J. Mohler   +19 more
doaj   +1 more source

VCAM-1 induces signals that stimulate ZO-1 serine phosphorylation and reduces ZO-1 localization at lung endothelial cell junctions [PDF]

Journal of Leukocyte Biology, 2018
Abstract Endothelial cell VCAM-1 regulates recruitment of lymphocytes, eosinophils, mast cells, or dendritic cells during allergic inflammation. In this report, we demonstrated that, during allergic lung responses, there was reduced zonula occludens (ZO)-1 localization in lung endothelial cell junctions, whereas there was increased lung ...
Hiam, Abdala-Valencia, Timothy S, Kountz, Michelle E, Marchese, Joan M, Cook-Mills   +3 more
openaire   +2 more sources

The proteasome regulates the interaction between Cx43 and ZO‐1 [PDF]

Journal of Cellular Biochemistry, 2007
AbstractGap junction (GJ) intercellular communication (GJIC) is vital to ensure proper cell and tissue function. GJ are multimeric structures composed of proteins called connexins. Modifications on stability or subcellular distribution of connexins have a direct impact on the extent of GJIC. In this study we have investigated the role of the proteasome
Girão, Henrique, Pereira, Paulo
openaire   +3 more sources

Yes-Associated Protein Is Required for ZO-1-Mediated Tight-Junction Integrity and Cell Migration in E-Cadherin-Restored AGS Gastric Cancer Cells

Biomedicines, 2021
Yes-associated protein (YAP) regulates numerous cellular homeostasis processes and malignant transformation. We found that YAP influences ZO-1-mediated cell migration using E-cadherin-restored EC96 cells derived from gastric malignant AGS cells.
Seon-Young Kim, Song-Yi Park, Hwan-Seok Jang, Yong-Doo Park, Sun-Ho Kee   +4 more
doaj   +1 more source

Syncytiotrophoblast of Placentae from Women with Zika Virus Infection Has Altered Tight Junction Protein Expression and Increased Paracellular Permeability

Cells, 2019
The cytotrophoblast of human placenta transitions into an outer multinucleated syncytiotrophoblast (STB) layer that covers chorionic villi which are in contact with maternal blood in the intervillous space. During pregnancy, the Zika virus (ZIKV) poses a
Jael Miranda, Dolores Martín-Tapia, Yolotzin Valdespino-Vázquez, Lourdes Alarcón, Aurora Espejel-Nuñez, Mario Guzmán-Huerta, José Esteban Muñoz-Medina, Mineko Shibayama, Bibiana Chávez-Munguía, Guadalupe Estrada-Gutiérrez, Samuel Lievano, Juan Ernesto Ludert, Lorenza González-Mariscal   +12 more
doaj   +1 more source

Lens connexins α3Cx46 and α8Cx50 interact with zonula occludens protein-1 (ZO-1) [PDF]

, 2003
Connexin α1Cx43 has previously been shown to bind to the PDZ domain–containing protein ZO-1. The similarity of the carboxyl termini of this connexin and the lens fiber connexins α3Cx46 and α8Cx50 suggested that these connexins may also interact with ZO-1.
Baruch, Amos, Benedetti, E. Lucio, Dunia, Irene, Giepmans, Ben N.G., Kumar, Nalin M, Nielsen, Peter A, Shestopalov, Valery I   +6 more
core   +3 more sources

27-Hydroxycholesterol induces expression of zonula occludens-1 in monocytic cells via multiple kinases pathways

Scientific Reports, 2022
Zonula occludens (ZO)-1, a tight-junction protein (TJP), is expressed in dendritic cells (DCs) but not in monocytes, and 27-hydroxycholesterol (27OHChol) drives the differentiation of monocytes into DCs.
Hyok-rae Cho, Bo-Young Kim, Koanhoi Kim, Dongjun Lee, Seong-Kug Eo, Yonghae Son   +5 more
doaj   +1 more source

The antimicrobial effects of zinc oxide-calcium hydroxide mixture fillers: determining the ideal mixture ratio

Iranian Journal of Microbiology, 2019
Background and Objectives: Although zinc oxide (ZO)-calcium hydroxide (CaOH) mixtures have been successful regarding their absorption rate compatibility with dissolving primary teeth, no study has been conducted on the appropriate mixture ratio to obtain
Ali Nozari, Ali Karimkhani, Mohammad Motamedifar, Payam Arasteh   +3 more
doaj   +1 more source