ZO-1 and ZO-2 are required for extra-embryonic endoderm integrity, primitive ectoderm survival and normal cavitation in embryoid bodies derived from mouse embryonic stem cells. [PDF]
PLoS ONE, 2014 The Zonula Occludens proteins ZO-1 and ZO-2 are cell-cell junction-associated adaptor proteins that are essential for the structural and regulatory functions of tight junctions in epithelial cells and their absence leads to early embryonic lethality in ...
Dominic C Y Phua +5 more
doaj +1 more source
Royal Society Open Science, 2023 Nano-zirconia (ZO) was synthesized using a microwave-assisted one-pot precipitation route. Two biopolymers, chitosan (CTS) and carboxymethyl cellulose were blended with ZO at different w/w ratios.
M. Shanika Fernando +7 more
doaj +1 more source
Tight junction protein ZO-1 in Kawasaki disease
, 2020 Abstract BackgroundKawasaki disease (KD) is a form of systemic febrile vasculitis that can be complicated by coronary artery lesions (CAL). A murine model of KD vasculitis showed that the vasculitis depended on intestinal barrier dysfunction, as well as that the tight junctions maintain the intestinal barrier.
Wan-Tz Lai +3 more
openaire +1 more source
ZO-1 is involved in trophoblastic cell differentiation in human placenta [PDF]
American Journal of Physiology-Cell Physiology, 2010 Trophoblastic cell-cell fusion is an essential event required during human placental development. Several membrane proteins have been described to be directly involved in this process, including connexin 43 (Cx43), syncytin 1 (Herv-W env), and syncytin 2 (Herv-FRD env glycoprotein).
Pidoux, Guillaume +10 more
openaire +2 more sources
MicroRNA‑103 regulates tumorigenesis in colorectal cancer by targeting ZO‑1
Molecular Medicine Reports, 2017 Given the emerging role of microRNAs (miRs) in cancer progression, the present study investigated the role and underlying mechanism of miR‑103 in colorectal cancer (CRC). Reverse transcription‑quantitative polymerase chain reaction was conducted to quantify the expression levels of miR‑103 in clinical specimens and cell lines.
Ke, Jin +5 more
openaire +3 more sources
Chronic inflammatory demyelinating polyneuropathy: decreased claudin-5 and relocated ZO-1 [PDF]
Journal of Neurology, Neurosurgery & Psychiatry, 2004 To clarify the dynamics of molecules composing the blood-nerve barrier (BNB) in inflammatory neuropathies.The expression of four tight junction (TJ) proteins-claudin-1, claudin-5, occludin, and ZO-1-was analysed immunohistochemically in sural nerve biopsy specimens obtained from patients with chronic inflammatory demyelinating polyradiculoneuropathy ...
T, Kanda, Y, Numata, H, Mizusawa
openaire +2 more sources
Comparative study of four immortalised human brain capillary endothelial cell lines, hCMEC/D3, hBMED, TY10, and BB19, and optimization of culture conditions, for an in vitro blood-brain barrier model for drug permeability studies [PDF]
, 2013 BACKGROUND: Reliable human in vitro blood–brain barrier (BBB) models suitable for high-throughput screening are urgently needed in early drug discovery and development for assessing the ability of promising bioactive compounds to overcome the BBB.
Eigenmann, Daniela E. +5 more
core +2 more sources
Pharmacology Research & Perspectives, 2022 An understanding of the quantitative relationship between bile canaliculus (BC) dynamics and the disruption of tight junctions (TJs) during drug‐induced intrahepatic cholestasis may lead to new strategies aimed at drug development and toxicity testing ...
Rie Sonoi, Yoshihisa Hagihara
doaj +1 more source
MicroRNA-103 regulates the progression in endometrial carcinoma through ZO-1 [PDF]
International Journal of Immunopathology and Pharmacology, 2019 Endometrial carcinoma (EC) is one of the most common gynecological cancers in many developing countries. Although tremendous advances have been made in the diagnosis and treatment of EC, there is still no adequate biomarker currently available for predicting the prognosis of this cancer.
Jing Du +4 more
openaire +2 more sources
Tilivalline- and Tilimycin-Independent Effects of Klebsiella oxytoca on Tight Junction-Mediated Intestinal Barrier Impairment [PDF]
, 2019 Klebsiella oxytoca causes antibiotic-associated hemorrhagic colitis and diarrhea. This was attributed largely to its secreted cytotoxins tilivalline and tilimycin, inductors of epithelial apoptosis.
Bücker, Roland +8 more
core +1 more source