Results 91 to 100 of about 17,751,190 (266)
E12.5 mouse dorsal cortex, R-Ras KO and mInsc OE, EGFP-ZO-1, mem-CyRFP
, 2019 Additional time-lapse movies for Figure 5j,k. E12.5 mouse dorsal cortex, R-Ras KO and mInsc OE, EGFP-ZO-1, mem-CyRFP. Z-projection images.
Atsunori Shitamukai (7859580) +1 more
core +1 more source
Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus
Advanced Science, EarlyView.This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan +11 more
wiley +1 more source
Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression
Hepatology, EarlyView., 2022 Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández +18 more
wiley +1 more source
Advanced Science, EarlyView.A thiol‐modified alginate hydrogel microsphere‐encapsulated enzyme‐probiotic biohybrid (AKK‐COD) system has been developed to address the spatiotemporal delivery and colonization challenges of small intestine‐targeted probiotic for lipid metabolism regulation. The system exerts sequential functions of intragastric protection, small intestinal adhesion,
Xiaolin Wu +10 more
wiley +1 more source
Zbavenie života zo strany štátu podĺa článku 2 ods. 2 Európskeho dohovoru o ĺudských právach
Časopis pro Právní Vědu a Praxi, 2003 Pri zabezpečovaní verejného poriadku, predchádzaní a zabraňovaní páchaniu trestných činov alebo priestupkov dochádza k rôznym situáciám, pri ktorých je potrebné použiť donucovacie prostriedky príslušníkmi bezpečnostných síl, čo může viesť k zásahu do ...
Branislav Hazucha
doaj
Frontiers in Microbiology, 2016 The gastrointestinal epithelial layer forms a physical and biochemical barrier that maintains the segregation between host and intestinal microbiota. The integrity of this barrier is critical in maintaining homeostasis in the body and its dysfunction is ...
Carina Shianya Alvarez +8 more
doaj +1 more source
ExEn organization and permeability is abnormal in EBs lacking ZO-1 and ZO-2.
, 2014 (A) Scanning electron micrographs. ExEn apical surface morphology of WT control and ZO gene-deleted EBs was analyzed by SEM. The apical surface of compacted ExEn cells can be seen covered with dense hair-like microvilli in WT (panel a) and ZO-2-/- (panel
Adrian Boey (573783) +5 more
core +1 more source
Advanced Science, EarlyView.TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin +11 more
wiley +1 more source
Advanced Science, EarlyView.Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk +9 more
wiley +1 more source
, 2006 Epithelial tight junctions participate in the regulation of gene expression by controlling the activity of transcription factors that can interact with junctional components.
Choquet, A +6 more
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