Results 101 to 110 of about 17,751,190 (266)

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

Biosynthesis of Sciadonic Acid Derived from Gymnosperms with Anti‐Colitis Activity

Advanced Science, EarlyView.
This study establishes an efficient Yarrowia lipolytica platform for unusual sciadonic acid (SCA) production and assess the anti‐colitis efficacy in mice of SCA, supporting its potential as a novel therapeutic lipid. ABSTRACT Sciadonic acid (SCA), Δ5‐unsaturated fatty acid with anti‐inflammatory and lipid‐regulatory properties, is predominantly derived
Yadi Gao, Wei Liu, Xiuping Liang, Jie Bai, Hong Chang, Wenchao Chen, Mohamed A. Farag, Jianbo Xiao, Huifeng Jiang, Jiasheng Wu, Lili Song   +10 more
wiley   +1 more source

GLS1 Orchestrates Exosome‐Mediated Tumor‐Endothelial Communication to Facilitate Angiogenesis

Advanced Science, EarlyView.
This study reveals a previously unappreciated, non‐metabolic function of GLS1 in the control of tumor angiogenesis via exosome‐mediated CAV1‐TNC signaling, indicating that therapeutic targeting of GLS1 may offer a dual benefit by simultaneously suppressing tumor metabolic activity and angiogenic processes in head and neck cancer. ABSTRACT Glutaminase 1
Jianqiang Yang, Zhenzhen Fu, Fanghui Chen, Soumya Vijaya Kumar, Fan Yang, Yaochao Zheng, Yunqi Li, Yao Yao, Nabil F. Saba, Yong Teng   +9 more
wiley   +1 more source

Formation of tight junction-like structures of zonula occludens 2 in platelet–platelet interaction

Research and Practice in Thrombosis and Haemostasis
Background: In tissues, cell–cell adhesion, barrier formation, and communication are regulated by gap, adherens, and tight junction (TJ) proteins. Platelets express several of these proteins.
Magdolna Nagy, Markus Bender, Natalie S. Poulter, Jeremy A. Pike, Albert Sickmann, Sonja Vondenhoff, Natalia Bielicka, Marc A.M.J. van Zandvoort, Rory R. Koenen, Hugo ten Cate, Xavier Stéphenne, Johan W.M. Heemskerk, Constance C.F.M.J. Baaten   +12 more
doaj   +1 more source

Characterization of the Interaction between Protein 4.1R and ZO-2 [PDF]

Journal of Biological Chemistry, 2000
Subhendra N. Mattagajasingh, Shu-Ching Huang, Julia S. Hartenstein, Edward J. Benz   +3 more
openaire   +1 more source

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host‐Derived 12‐HEPE Against Ulcerative Colitis

Advanced Science, EarlyView.
A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen, Mingyue Shen, Rui Zhang, Zhibing Huang, Hui Niu, Qiang Yu, Yi Chen, Xiangwen Pan, Liyuan Rong, Huiliang Wen, Jun Yang, Jianhua Xie   +11 more
wiley   +1 more source

Effects of Momordica charantia (Bitter Melon) on Ischemic Diabetic Myocardium

Molecules, 2017
Objective: A rat model is here used to test a hypothesis that Momordica charantia (Bitter melon (BM)) extract favorably alters processes in cardiovascular tissue and is systemically relevant to the pathophysiology of type 2 diabetes (T2DM) and related ...
Attila Czompa, Alexandra Gyongyosi, Kitti Szoke, Istvan Bak, Evelin Csepanyi, David D. Haines, Arpad Tosaki, Istvan Lekli   +7 more
doaj   +1 more source

A Microgel Platform Enables Site‐Specific Intestinal Delivery of Lactoferrin, Improving its Bioavailability for Targeted Alleviating Liver Injury and Colitis

Advanced Science, EarlyView.
This work first time reports an eco‐friendly desert plant food‐based polysaccharide ASKP microgels which have intestinal site‐specific release properties which can achieve small‐intestine or colon targeting capability via different cross‐linking chemistry.
Huiling Yan, Yixuan Li, Shanan Chen, Pengcheng Du, Kaiwen Wu, Hui Zhang, Kasper Hettinga, Lina Zhang, Gergely Toldi, Fazheng Ren, Yuan Li   +10 more
wiley   +1 more source

Cinnamicaldehyde regulates the expression of tight junction proteins and amino acid transporters in intestinal porcine epithelial cells

Journal of Animal Science and Biotechnology, 2017
Background Cinnamicaldehyde (CA) is a key flavor compound in cinnamon essential oil possessing various bioactivities. Tight junction (TJ) proteins are vital for the maintenance of intestinal epithelial barrier function, transport, absorption and ...
Kaiji Sun, Yan Lei, Renjie Wang, Zhenlong Wu, Guoyao Wu   +4 more
doaj   +1 more source

ZO-1 is important for the formation of glial sealing in the outer retina.

, 2016
Confocal micrographs of vertical sections labeled with ß-tubulin (A, B) and GFAP (C,D) in retinas treated with non-targeting siRNA (A, C) and ZO-1 siRNA (B, D).
Cheryl Mae Craft (3179256), Divya Nair (3179268), Norberto M. Grzywacz (3179259), Eun-Jin Lee (2299186), Yun Sung Eom (3179274), Jung-A Shin (3179265), Sara X. Z. Grzywacz (3179271), Wan-Qing Yu (3179262)   +7 more
core   +1 more source