Results 81 to 90 of about 24,539,782 (228)

Understanding the mobile healthcare applications continuance: The regulatory focus perspective

open access: yes, 2023
Background: Although mobile healthcare (mHealth) applications have proliferated and offer new opportunities for personal health management, many users exhibit discontinuance behavior. Various factors in mHealth applications can strongly impact users'
Hangjung Zo   +3 more
core   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

open access: yesAdvanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori   +10 more
wiley   +1 more source

Zbavenie života zo strany štátu podĺa článku 2 ods. 2 Európskeho dohovoru o ĺudských právach

open access: yesČasopis pro Právní Vědu a Praxi, 2003
Pri zabezpečovaní verejného poriadku, predchádzaní a zabraňovaní páchaniu trestných činov alebo priestupkov dochádza k rôznym situáciám, pri ktorých je potrebné použiť donucovacie prostriedky príslušníkmi bezpečnostných síl, čo může viesť k zásahu do ...
Branislav Hazucha
doaj  

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

open access: yesAdvanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li   +23 more
wiley   +1 more source

Morphology-driven zinc oxide biointeractive carriers with biological barrier modulating effects for pulmonary delivery of liraglutide

open access: yesJournal of Nanobiotechnology
Pulmonary delivery provides a noninvasive route for systemic administration of biologics, yet efficient lung deposition and permeation across pulmonary barriers remain major challenges.
Jin-Hyuk Jeong   +4 more
doaj   +1 more source

Outer membrane vesicles and soluble factors released by probiotic Escherichia coli Nissle 1917 and commensal ECOR63 enhance barrier function by regulating expression of tight junction proteins in intestinal epithelial cells

open access: yesFrontiers in Microbiology, 2016
The gastrointestinal epithelial layer forms a physical and biochemical barrier that maintains the segregation between host and intestinal microbiota. The integrity of this barrier is critical in maintaining homeostasis in the body and its dysfunction is ...
Carina Shianya Alvarez   +8 more
doaj   +1 more source

Network Closure Versus Structural Hole: The Role of Knowledge Spillover Networks in National Innovation Performance

open access: yes, 2022
The main sources of technological development are from abroad rather than domestic in many countries. The global networks for knowledge and technology flows are becoming sophisticated. This article examines how a country's embeddedness in the global
Zo, Hangjung, Choi, Hyeri
core   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

open access: yesAdvanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal   +5 more
wiley   +1 more source

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