Results 61 to 70 of about 17,751,190 (266)

Context-dependent interactions among afadin, ZO-1, and actin filaments

Cell Structure and Function
Afadin and ZO-1 are actin-binding scaffold proteins localized at cell-cell junctions. Although these proteins contain multiple protein-binding motifs for various junctional proteins, their binding partners within cells are strictly regulated.
Yuji Nitta, Satoshi Urayama, Maki Kawashima, Hayato Nakao, Takafumi Ikeda, Kazushi Higashiyama, Hatsuki Murakami, Chiyoko Kobayashi, Yuichiro Kano, Mikio Furuse, Akira Nagafuchi   +10 more
doaj   +1 more source

Lipopolysaccharide downregulates the expression of ZO-1 protein through the Akt pathway

BMC Infectious Diseases, 2022
Background Neonatal bacterial meningitis is a common neonatal disease with high morbidity, and can cause serious sequelae when left untreated. Escherichia coli is the common pathogen, and its endotoxin, lipopolysaccharide (LPS) can damage the endothelial
Peicen Zou, Fan Yang, Yijun Ding, Di Zhang, Ying Liu, Jinjing Zhang, Dan Wu, Yajuan Wang   +7 more
doaj   +1 more source

Effects of ZO-1 knockout on the localization of ZO-2 and ZO-3.

, 2014
(A) Effects of ZO-1 knockout on the localization of ZO-2 in MDCK II cells. The images in Figure 1 were used for the analysis. Signal intensity of ZO-2 and ZO-1 on lines shown in confocal microscopic image (arrows) were analyzed.
Mikio Furuse (621728), Tomohito Higashi (621727), Shinsaku Tokuda (621726)   +2 more
core   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

E12.5 mouse dorsal cortex, mInsc OE, EGFP-ZO-1, mem-CyRFP

, 2019
Additional time-lapse movies for Figure 5e,f. E12.5 mouse dorsal cortex, mInsc OE, EGFP-ZO-1, mem-CyRFP.
Atsunori Shitamukai (7859580), Fumio Matsuzaki (131236)   +1 more
core   +2 more sources

ZO-1 Regulates Hippo-Independent YAP Activity and Cell Proliferation via a GEF-H1- and TBK1-Regulated Signalling Network

Cells
Tight junctions are a barrier-forming cell–cell adhesion complex and have been proposed to regulate cell proliferation. However, the underlying mechanisms are not well understood.
Alexis J. Haas, Mert Karakus, Ceniz Zihni, Maria S. Balda, Karl Matter   +4 more
doaj   +1 more source

ROS attenuates TET2-dependent ZO-1 epigenetic expression in cerebral vascular endothelial cells

Fluids and Barriers of the CNS, 2022
Keypoints 1. The expression of tight junction protein ZO-1 decreased significantly in the aged human brain. 2. TET activity of cerebral endothelial cells declines during aging. 3.
Lan Wang, Bei Mao, Keyang Fan, Renqiang Sun, Jialong Zhang, Huazheng Liang, Ying Liu   +6 more
doaj   +1 more source

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Retinoic Acid Facilitates Toll-Like Receptor 4 Expression to Improve Intestinal Barrier Function through Retinoic Acid Receptor Beta

Cellular Physiology and Biochemistry, 2017
Background/Aims: Vitamin A (VA) protects the intestinal epithelial barrier by improving cell migration and proliferation. Our previous studies demonstrated that VA deficiency (VAD) during pregnancy suppresses the systemic and mucosal immune responses in ...
Yingying Li, Yuan Gao, Ting Cui, Ting Yang, Lan Liu, Tingyu Li, Jie Chen   +6 more
doaj   +1 more source

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

Advanced Healthcare Materials, EarlyView.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino, Lucia Pappagallo, Francesca De Chirico, Luca Boselli, Hazem Ahmed, Luca Spagnoletti, Giovanni Pittaluga, Paolo Emidio Costantini, Matteo Calvaresi, Pier Paolo Pompa, Alberto Danielli, Fabio Benfenati, Valentina Castagnola   +12 more
wiley   +1 more source