Results 61 to 70 of about 24,539,782 (228)

Probiotics modify tight-junction proteins in an animal model of nonalcoholic fatty liver disease

Therapeutic Advances in Gastroenterology, 2016
Background: We have investigated the effects of a multispecies probiotic preparation containing a combination of probiotic bacterial genera that included Bifidobacteria, Lactobacilli and a Streptococcus in a mouse model of high-fat diet or obesity ...
David Briskey, Mandy Heritage, Lesley-Anne Jaskowski, Jonathan Peake, Glenda Gobe, V. Nathan Subramaniam, Darrell Crawford, Catherine Campbell, Luis Vitetta   +8 more
doaj   +1 more source

ZO-1 and ZO-2 Independently Determine Where Claudins Are Polymerized in Tight-Junction Strand Formation [PDF]

, 2006
SummaryA fundamental question in cell and developmental biology is how epithelial cells construct the diffusion barrier allowing them to separate different body compartments.
Furuse, Mikio, Tsukita, Shoichiro, Furuse, Kyoko, Matsui, Takeshi, Sasaki, Hiroyuki, Ikenouchi, Junichi, Nakayama, Mayumi, Katahira-Tayama, Sayaka, Umeda, Kazuaki, Tsukita, Sachiko   +9 more
core   +1 more source

Liquid‐Crystal‐Based Reconfigurable Intelligent Surface for 7 GHz Mobile Communication

Advanced Materials Technologies, EarlyView.
The glass‐based liquid‐crystal reconfigurable intelligent surface (LC‐RIS) integrates active‐matrix driving and blind‐greedy phase optimization within a 5G‐NR OFDM framework. This enables continuously tunable and autonomous enhancement of wireless coverage. Leveraging the transparency and manufacturability of liquid crystal panels, it is ideally suited
Tien‐Lun Ting, Yuh‐Chyi Chang, Yi‐Chan Hung, Cheng‐Yuan Hsiao, Chao‐Kai Wen, Tsung‐Hsien Lin   +5 more
wiley   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Subcellular Distribution of Tight Junction-Associated Proteins (Occludin, ZO-1, ZO-2) in Rodent Skin [PDF]

, 1998
Occludin is an integral membrane protein that is concentrated at tight junctions (zonulae occludentes) in simple epithelial cells. ZO-1 and ZO-2 are peripheral membrane proteins that are localized at tight junctions in simple epithelial cells and at ...
Furuse, Mikio, Morita, Kazumasa, Tsukita, Shoichiro, Ando-Akatsuka, Yuhko, Saitou, Mitinori, Itoh, Masahiko, Imamura, Sadao, Fujimoto, Kazushi, Yoneda, Kozo   +8 more
core   +1 more source

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

E12.5 mouse dorsal cortex, mInsc OE, EGFP-ZO-1, mem-CyRFP

, 2019
Additional time-lapse movies for Figure 5e,f. E12.5 mouse dorsal cortex, mInsc OE, EGFP-ZO-1, mem-CyRFP.
Atsunori Shitamukai (7859580), Fumio Matsuzaki (131236)   +1 more
core   +2 more sources

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Effects of ZO-1 knockout on the localization of ZO-2, ZO-3 and occludin in the stable ZO-1 knockout clones.

, 2014
(A) Immunofluorescence microscopic analysis and line scanning of ZO-1 and ZO-2 in ZO-1 knockout clones 1 (KO 1) and 3 (KO 3) co-cultured with control cells. ZO-2 fluorescent signal at TJs was reduced in KO 1 but was slightly increased in KO 3.
Mikio Furuse (621728), Tomohito Higashi (621727), Shinsaku Tokuda (621726)   +2 more
core   +1 more source

Oral Prebiotic Polysaccharide Hydrogels Sustaining Colon Antibody Release Alleviate Inflammatory Bowel Disease

Advanced Science, EarlyView.
An orally administered prebiotic polysaccharide hydrogel (predaGel) based on inulin and alginate‐dopamine is stable in the stomach, adheres to the intestine, and degrades slowly in the colon. It enables site‐specific delivery of anti‐TNF‐α and anti‐IL‐12/23 antibodies, scavenges reactive oxygen species, and remodels gut microbiota, offering effective ...
Xinyi Dong, Huan He, Li Cao, Fenghua Meng, Zhiyuan Zhong   +4 more
wiley   +1 more source