Results 131 to 140 of about 24,539,782 (228)

Oligosaccharides With Defined Glycosidic Bonds Shape Gut Microbial Succession and Metabolism Via Bond‐Specific Microbial Responders

Advanced Science, EarlyView.
Oligosaccharides with defined glycosidic bonds drive divergent gut microbial succession and shape unique metabolic profiles. Absolute time‐series profiling with Bayesian generalized Lotka–Volterra modeling identifies bond‐specific microbial responders, while monoculture validation and metaproteomics reveal linkage‐matched transport and cleavage modules.
Xiaoxuan Lu, Jiaqi Zou, Geng Han, Mengyao Zhao, Ting Luo, Xiangru Feng, Liangliang Zhu, Yijia Chen, Xiaoguo Ji, Jiayang Jin, Liming Zhao   +10 more
wiley   +1 more source

Assessing the efficiency of national innovation systems in developing countries

, 2019
Despite the growing importance of developing countries to the global economy and their increasing role in innovation, limited academic attention has been given to the national innovation systems (NIS) of these countries. Given that they commonly suffer a
Zo, Hangjung, Choi, Hyeri
core   +1 more source

Multifunctional Zinc Glycyrrhizinate‐Integrated Gel for Enhanced Probiotic Delivery and Alleviation of Acute and Spontaneous Colitis

Advanced Science, EarlyView.
Multifunctional oral delivery system—L. reuteri@ZGM—act as both a carrier and therapeutic adjuvant, providing ROS scavenging, and mucin‐interactive properties tailored to the IBD microenvironment. This bioactive gel safeguards L. reuteri from gastric degradation, enhances mucosal adhesion, and promotes long‐term retention at inflamed sites, thereby ...
Mengyun Peng, Xiaochun Chen, Wei Li, Shu Tang, Jun Zhou, Xia Wu, Dan Yuan, Zhongyan Shan, Junfeng Shi   +8 more
wiley   +1 more source

Microglial TSPAN4‐Dependent Migrasomes Promote Pathological Retinal Neovascularization via Immune‐Vascular Crosstalk

Advanced Science, EarlyView.
Combined high‐glucose and hypoxic stress switches microglia into a TSPAN4‐dependent migrasome‐producing state. These migrasomes deliver pro‐angiogenic signals to endothelial cells, activating HIF‐1α/VEGF signaling, disrupting vascular junctions, and fueling pathological neovascularization. This work uncovers migrasome‐mediated immune‐vascular crosstalk
Jingyi Xu, Jingfan Wang, Pengfei Ge, Qinyuan Gu, Hongying Li, Yuanyuan Fan, Haiyue Xie, Yangyang Lu, Yifan Lin, Xinjing Wu, Chengkun Wang, Ping Xie, Zizhong Hu   +12 more
wiley   +1 more source

Adhesion‐Enhanced Engineered Probiotic for Prolonged Intestinal Retention and Calprotectin‐Responsive IBD Therapy

Advanced Science, EarlyView.
An intelligent engineered probiotic platform is developed for the precision management of inflammatory bowel disease. By integrating surface‐displayed adhesins with an inflammation‐responsive CAT‐SOD‐GPx tripartite fusion system and mucosal repair factors, this programmable system achieves prolonged intestinal retention and multi‐pronged therapy.
Yuxi Wang, Peichao Zhang, Simin Gu, Hongyun Lu, Ningning Jiang, Jiarun Zhao, Enbo Xu, Xiayu Liu, Ying Shi, Qihe Chen   +9 more
wiley   +1 more source

Identifizierung und funktionelle Charakterisierung der SUMOylierung des Tight Junction-Proteins Zona occludens-2 (ZO-2) [PDF]

, 2016
Die Aufrechterhaltung und Integrität von Tight Junctions (TJs) ist von zentraler Bedeutung für die Zellpolarität in epithelialen und endothelialen Geweben.
Wetzel, Franziska
core  

Private omgevingsparticipatie, maar dan met de gemeente: zo doe je dat

, 2022
TU Delft-onderzoeker Wouter Jan Verheul onderzocht van 15 gemeenten hun handreikingen voor participatie door private initiatiefnemers. Zo brengt hij in kaart wat de verhouding is tussen private en publieke partijen bij omgevingsparticipatie.Urban ...
Verheul, W.J. (author)
core  

SAV1 in Cooperation With FKBP52 Participates in Implantation

Advanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan   +10 more
wiley   +1 more source

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng, Wen Gao, Jonathan Do, Danli Lu, Ying‐Wei Lan, Andreas Damianos, Gautam Verma, Ali Al Siraj, Isabella Lowry, Lance Peter, Nicholas E. Banovich, Fei Sun, Hua He, Tanya V. Kalin, Vladimir V. Kalinichenko   +14 more
wiley   +1 more source

Dose Severity of Achilles Tendinopathy on Preoperative MRI Predict Functional Outcomes after Minimally Invasive Zadek Osteotomy?

Foot & Ankle Orthopaedics
Category: Hindfoot; Ankle Introduction/Purpose: Minimally Invasive Zadek osteotomy (MIS ZO) has been demonstrated to be a safe and effective surgical intervention for patients with Insertional Achilles Tendinopathy (IAT) and Haglund’s deformity. However,
Sarah Hall BA, Jonathan Kaplan MD, Oliver Schipper MD, A. Holly Johnson MD, Ettore Vulcano MD, J. Benjamin Jackson MD, MBA, Tyler Gonzalez MD, MBA   +6 more
doaj   +1 more source