Results 11 to 20 of about 8,610 (178)
MiR-144 Increases Intestinal Permeability in IBS-D Rats by Targeting OCLN and ZO1 [PDF]
Cellular Physiology and Biochemistry, 2017 Background/Aims: Irritable bowel syndrome with diarrhoea (IBS-D) is a chronic, functional bowel disorder characterized by abdominal pain or diarrhoea and altered bowel habits, which correlate with intestinal hyperpermeability.
Qiuke Hou +6 more
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SARS-CoV-2 Envelope (E) protein interacts with PDZ-domain-2 of host tight junction protein ZO1. [PDF]
PLoS ONE, 2021 Newly emerged SARS-CoV-2 is the cause of an ongoing global pandemic leading to severe respiratory disease in humans. SARS-CoV-2 targets epithelial cells in the respiratory tract and lungs, which can lead to amplified chloride secretion and increased leak
Ariel Shepley-McTaggart +10 more
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Claudin‐2 promotes colorectal cancer growth and metastasis by suppressing NDRG1 transcription
Clinical and Translational Medicine, 2021 Colorectal cancer (CRC) is one of the most common malignant tumours, with multiple driving factors and biological transitions involved in its development.
Mingtian Wei +14 more
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, 2023 Cultured human podocytes were infected with lentiviral particle encoding pre-hsa-miR-143-3p, pre-hsa-miR-145-5p, or scrambled control allele (Sc) and subjected to following analysis. (A) After incubation with or without 5 ng/mL TGF-β1 for 24 hours, ZO1 mRNA expression levels were examined by RT-qPCR.
Toru Sakairi (15063751)
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, 2023 Podocytes were cultured with dimethyl sulfoxide (DMSO) as vehicle control alone, 20 nM rapamycin (Rapa) alone, DMSO plus 5 ng/mL TGF-β1, or 20 nM Rapa plus 5 ng/mL TGF-β1 for 24 hours. (A) In podocytes exposed to DMSO plus TGF-β1, F-actin stress fiber formation was enhanced, ZO1 expression at intercellular junctions was decreased, and α-SMA expression ...
Toru Sakairi (15063751)
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Decreased ZO1 expression causes loss of time-dependent tight junction function in the liver of ob/ob mice [PDF]
Molecular Biology Reports, 2021 Abstract Diabetes patients are at a high risk of developing complications related to angiopathy and disruption of the signal transduction system. The liver is one of the multiple organs damaged during diabetes. Few studies have evaluated the morphological effects of adhesion factors in diabetic liver. The influence of diurnal variation has been
Yuya Tsurudome +3 more
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Journal of Molecular Cell Biology, 2021 Abstract Alternative splicing (AS) and transcription elongation are vital biological processes, and their dysregulation causes multiple diseases, including tumors. However, the coregulatory mechanism of AS and transcription elongation in tumors remains unclear.
Han, Fengyan +8 more
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Nano-scale architecture of blood-brain barrier tight-junctions
eLife, 2021 Tight junctions (TJs) between blood-brain barrier (BBB) endothelial cells construct a robust physical barrier, whose damage underlies BBB dysfunctions related to several neurodegenerative diseases.
Esther Sasson +10 more
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EFFECTS OF Ang-1 MIMICKING PEPTIDE IN SYNERGY WITH VASCULAR ENDOTHELIAL GROWTH FACTOR ON CARDIAC FUNCTION IN RATS WITH MYOCARDIAL INFARCTION [PDF]
精准医学杂志, 2023 Objective To investigate the effects of cardiac extracellular matrix (c-ECM) combined with collagen-binding vascular endothelial growth factor (CBD-VEGF) and Ang-1 mimicking peptide (AMP) on cardiac function in rats with myocardial infarction (MI ...
WANG Junke, SONG Siqi, SHI Chunying, YU Zhongxiang
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