Results 41 to 50 of about 203,986 (346)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
A Goldilocks approach to transdisciplinary learning
Journal of the European Honors CouncilIn today’s world, education is increasingly being called upon to do more. Beyond transmitting knowledge, we need to cultivate both capability and agency in learners to navigate the complexity and uncertainty of our time.
Jan-Peter Sandler
doaj +3 more sources
Creating a bigger ZPD by extending learning process via online forum [PDF]
, 2007 Formal learning usually takes place in a four wall classroom. An extension of learning process may continue to occur in a conventional setting where learners get together physically after class hours.
Hussin, Supyan
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
ATF3 upregulation in glia during Wallerian degeneration: differential expression in peripheral nerves and CNS white matter [PDF]
, 2004 Background: Many changes in gene expression occur in distal stumps of injured nerves but the transcriptional control of these events is poorly understood.
Anderson, PN +6 more
core +3 more sources
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
'Philosophy for children' as creating the zone of proximal development [PDF]
Psihološka Istraživanja, 2014 In this paper, we analyze the conception, objectives and methodology of the 'Philosophy for Children', a programme aimed at fostering critical thinking in children aged five to eighteen.
Pešić Jelena, Zrenjanin Ana
doaj +1 more source
Teacher Feedback, Learner Dialogue, and the Zone of Proximal Development [PDF]
, 2012 リキャストなど口頭訂正フィードバックの第二言語習得過程における役割や効果についての研究は、これまで、いわゆるインプット－インタラクション－アウトプットのモデルを用いて行われてきた。しかし、このモデルでは談話が一元的な発話の積み重ねとして捉えられるため、訂正フィードバックの機能や仕組みが曖昧である。本稿では、教師の口頭訂正フィードバックを含む談話を、社会文化的理論（Sociocultural Theory）の視点で考察する。社会文化的理論では、談話には、時として問題解決を目的とした認知的活動の「場 ...
Nabei Toshiyo, 名部井 敏代
core +1 more source
Learning conversions in science: The case of vocational students in the UK [PDF]
, 2000 The paper describes two aspects of a research project that focused on vocational science students. The paper begins with a general description of vocational science in the UK, to put the work in context.
Butterfield, Anne +2 more
core +3 more sources
Advanced Functional Materials, EarlyView.Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana +2 more
wiley +1 more source