Results 31 to 40 of about 8,358 (142)

Safety and efficacy of cannabidiol-cannabidiolic acid rich hemp extract in the treatment of refractory epileptic seizures in dogs

Frontiers in Veterinary Science, 2022
The use of cannabidiol (CBD) in childhood refractory seizures has become a common therapeutic approach for specific seizure disorders in human medicine.
Gabriel A. Garcia, Stephanie Kube, Sheila Carrera-Justiz, David Tittle, Joseph J. Wakshlag   +4 more
doaj   +1 more source

Immune‐mediated polyarthritis and anterior uveitis secondary to zonisamide administration in a dog with refractory epilepsy

Veterinary Medicine and Science
The objective of this article is to describe a case of suspected zonisamide‐induced immune‐mediated polyarthritis (IMPA) and anterior uveitis in a dog.
Paula Baya, Saya Press, Stephanie Istvan, Kaila Rizzo   +3 more
doaj   +1 more source

Zonisamide Ameliorated the Apoptosis and Inflammation in Cerebellar Tissue of Induced Alcohol Addiction Animal Model

Life
This study investigated the effects of zonisamide treatment on cerebellar tissues in an experimental alcohol addiction (AA) model and its potential mechanisms of action, particularly regarding apoptotic protease activating factor-1 (APAF-1) and tumor ...
Fırat Aşır, Fikri Erdemci, Zuhal Çankırı, Tuğcan Korak, Süreyya Özdemir Başaran, Özge Kaplan, Özkan Yükselmiş, Nilüfer Dönmezdil, Hayat Ayaz, Şehmus Kaplan, Selçuk Tunik   +10 more
doaj   +1 more source

Data for zonisamide effect on length and weight of 14 day-old rat pups and abortion rate and day in refractory epileptic pregnant rats

Data in Brief, 2018
Length and weight of 14 day-old rat pups and also abortion rate and day on refractory epileptic pregnant rats after treatment with zonisamide (ZNS) are presented.
Reza Narenji Sani, Keivan Keramati, Niloufar Saberi, Melika Moezifar, Ali Mahdavi   +4 more
doaj   +1 more source

Upregulated Connexin 43 Induced by Loss-of-Functional S284L-Mutant α4 Subunit of Nicotinic ACh Receptor Contributes to Pathomechanisms of Autosomal Dominant Sleep-Related Hypermotor Epilepsy

Pharmaceuticals, 2020
To study the pathomechanism and pathophysiology of autosomal dominant sleep-related hypermotor epilepsy (ADSHE), this study determined functional abnormalities of glutamatergic transmission in the thalamocortical motor pathway, from the reticular ...
Kouji Fukuyama, Masashi Fukuzawa, Ruri Okubo, Motohiro Okada   +3 more
doaj   +1 more source

The effect of oral zonisamide treatment on serum phenobarbital concentrations in epileptic dogs

Frontiers in Veterinary Science
Zonisamide is used in dogs for the treatment of epileptic seizures. It is predominantly metabolised by CYP450 hepatic enzymes. When used concurrently with phenobarbital (PB), zonisamide clearance is increased and its elimination half-life decreases ...
Elizabeth Mahon, Oliver Marsh, Ane Uriarte, Fabio Stabile   +3 more
doaj   +1 more source

Paths for Improving Bevacizumab Available in 2018: The ADZT Regimen for Better Glioblastoma Treatment

Medical Sciences, 2018
During glioblastoma treatment, the pharmaceutical monoclonal antibody to vascular endothelial growth factor A, bevacizumab, has improved the quality of life and delayed progression for several months, but has not (or only marginally) prolonged overall ...
Richard E. Kast
doaj   +1 more source

Silicate Urolithiasis during Long-Term Treatment with Zonisamide

Case Reports in Medicine, 2013
Silicate urinary calculi are rare in humans, with an incidence of 0.2% of all urinary calculi. Most cases were related to excess ingestion of silicate, typically by taking magnesium trisilicate as an antacid for peptic ulcers over a long period of time ...
Satoru Taguchi, Yorito Nose, Toshikazu Sato, Teruaki Kobayashi, Kanami Takaya, Akira Ishikawa, Yukio Homma   +6 more
doaj   +1 more source

X-Linked Infantile Spasms

Pediatric Neurology Briefs, 1997
Two unrelated families with X-linked infantile spasm syndrome were studied genetically by two-point and multipoint linkage analyses at the University Hospital Gasthuisberg, and Center for Human Genetics, University of Leuven, and University of Antwerp ...
J Gordon Millichap
doaj   +1 more source

The Effect of Zonisamide on Sex Hormones Level and Testis Histological Changes in Adult MaleRat

Armaghane Danesh Bimonthly Journal, 2014
Background and aim: Zonisamide is an inhibitor for glutamate neurotransmitter and gamma aminobutiric acid (GABA)-mediators. It also increases the total levels of serotonin.
M Mallaki, M Shariati, L Sepehrara
doaj