Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions [PDF]
Nature Communications, 2016 Alcohol abuse is a risk factor for acute respiratory distress syndrome, flooding of the lungs due to compromised barrier function. Here the authors report that alcohol upregulates claudin-5 that is then recruited to tight junctions in alveolar epithelial
Barbara Schlingmann +9 more
doaj +6 more sources
Calcitonin Receptor-Zonula Occludens-1 Interaction Is Critical for Calcitonin-Stimulated Prostate Cancer Metastasis. [PDF]
PLoS ONE, 2016 The role of neuroendocrine peptide calcitonin (CT) and its receptor (CTR) in epithelial cancer progression is an emerging concept with great clinical potential.
Ahmed Aljameeli +5 more
doaj +8 more sources
Protects Porcine Intestinal Barrier from Deoxynivalenol via Improved Zonula Occludens-1 Expression [PDF]
Asian-Australasian Journal of Animal Sciences, 2014 Intestinal epithelial cells (IECs) forming the barrier for the first-line of protection are interconnected by tight junction (TJ) proteins. TJ alteration results in impaired barrier function, which causes potentially excessive inflammation leading to ...
Min Jeong Gu +4 more
doaj +7 more sources
Zonula occludens-1 distribution and barrier functions are affected by epithelial proliferation and turnover rates. [PDF]
Cell Prolif, 2023 Zonula occludens‐1 (ZO‐1) is a scaffolding protein of tight junctions, which seal adjacent epithelial cells, that is also expressed in adherens junctions.
Imafuku K +8 more
europepmc +4 more sources
Increased systemic zonula occludens 1 associated with inflammation and independent biomarker in patients with hepatocellular carcinoma [PDF]
BMC Cancer, 2018 Background Hepatocellular carcinoma (HCC) is a frequent type of primary liver cancer, and its prevalence is increasing worldwide. Indeed, the underlying molecular mechanism is not well understood. Previous studies have shown evidence that tight junction (
Amit Kumar Ram +2 more
doaj +3 more sources
Zonula occludens-1 expression is reduced in nasal epithelial cells of allergic rhinitis patients [PDF]
PeerJ, 2022 Allergic rhinitis (AR) is a common allergic disease characterized by disruption of nasal epithelial barrier. In this study, we investigated the mRNA expression of zonula occludens-1 (ZO-1), ZO-2 and ZO-3 and histone deacetylase 1 (HDAC1) and HDAC2 in AR ...
Che Othman Siti Sarah +4 more
doaj +5 more sources
Altered Expression of Zonula occludens-1 Affects Cardiac Na+ Channels and Increases Susceptibility to Ventricular Arrhythmias [PDF]
Cells, 2022 Zonula occludens-1 (ZO-1) is an intracellular scaffolding protein that orchestrates the anchoring of membrane proteins to the cytoskeleton in epithelial and specialized tissue including the heart.
Mona El Refaey +19 more
doaj +5 more sources
Spatial Overlap of Claudin- and Phosphatidylinositol Phosphate-Binding Sites on the First PDZ Domain of Zonula Occludens 1 Studied by NMR [PDF]
Molecules, 2018 Background: The tight junction is an intercellular adhesion complex composed of claudins (CLDs), occludin, and the scaffolding proteins zonula occludens 1 (ZO-1) and its two paralogs ZO-2 and ZO-3.
Hidekazu Hiroaki +7 more
doaj +3 more sources
Anisakis simplex products impair intestinal epithelial barrier function and occludin and zonula occludens-1 localisation in differentiated Caco-2 cells. [PDF]
PLoS Negl Trop Dis, 2020 Background Anisakis spp. are nematode parasites found in a wide range of marine organisms. Human beings may accidentally become infected, showing the symptoms of anisakiasis and allergic responses.
Carballeda-Sangiao N +6 more
europepmc +2 more sources
Propofol improved hypoxia-impaired integrity of blood-brain barrier via modulating the expression and phosphorylation of zonula occludens-1. [PDF]
CNS Neurosci Ther, 2019 Hypoxia may damage blood‐brain barrier (BBB). The neuroprotective effect of propofol has been reported. We aimed to identify whether and how propofol improved hypoxia‐induced impairment of BBB integrity.
Chen W +5 more
europepmc +2 more sources