Results 201 to 210 of about 31,557 (233)
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Diminished zonula occludens-1 expression in the failing human heart
Cardiovascular Pathology, 2007Reduced expression of the major gap junction protein connexin 43 (Cx43) in the failing human heart may lead to arrhythmias and sudden cardiac death. Cx43 interacts with the actin binding protein, zonula occludens-1 (ZO-1), and it has recently been demonstrated that ZO-1 regulates the formation and function of Cx43 gap junctions.
James G, Laing +3 more
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Zonula Occludens-1 and HER-2/neu Expression in Invasive Breast Carcinoma
Applied Immunohistochemistry & Molecular Morphology, 2003A subset of breast carcinomas shows unexplained overexpression of HER-2/neu protein without HER-2/neu gene amplification. These tumors are often scored 2+ by immunohistochemistry (DAKO HercepTest). In vitro, Zonula occludens-1 (ZO-1), a tight junction protein, can upregulate HER-2/neu expression by sequestering a repressor of the HER-2/neu gene ...
Julie, Bell +3 more
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Elevated systemic zonula occludens 1 is positively correlated with inflammation in cirrhosis
Clinica Chimica Acta, 2018It has been well established that disruption of the intestinal barrier function and increased intestinal permeability contribute to endotoxemia and associated liver injury in patients with cirrhosis. However, the relationship between systemic inflammation and tight junction protein in cirrhosis remain unidentified.
Ashwini Karthikeyan +3 more
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Zonula Occludens-1 alterations and enhanced intestinal permeability in methotrexate-treated rats
Cancer Chemotherapy and Pharmacology, 2010The molecular mechanisms that underlie the methotrexate (MTX)-mediated disruption of intestinal barrier function have not been fully characterized. Epithelial barrier function is determined in large part by a multiprotein complex located at the most apical part of the lateral membrane, which is referred to as a tight junction (TJ). In the present study,
Kazuma, Hamada +3 more
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Age-related changes in rat cerebral occludin and zonula occludens-1 (ZO-1)
Mechanisms of Ageing and Development, 2003The endothelial or epithelial tight junctions create a rate-limiting barrier to diffusion of solutes. A major determinant of the barrier function is the density of tight junction proteins. Since aging is associated with significant alterations in the blood-brain barrier (BBB) it is possible that specific tight junction proteins may be altered in the ...
Arshag D, Mooradian +2 more
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Microvascular Research, 2015
Zonula occludens-1 (ZO-1) is essential to the proper assembly of interendothelial junction complexes that control blood-brain barrier (BBB) integrity. The goal of the current paper was to improve our understanding of how proinflammatory cytokines modulate ZO-1 properties within the human BBB microvascular endothelium.
Keith D, Rochfort, Philip M, Cummins
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Zonula occludens-1 (ZO-1) is essential to the proper assembly of interendothelial junction complexes that control blood-brain barrier (BBB) integrity. The goal of the current paper was to improve our understanding of how proinflammatory cytokines modulate ZO-1 properties within the human BBB microvascular endothelium.
Keith D, Rochfort, Philip M, Cummins
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Zonula occludens‐1/NF‐κB/CXCL8: a new regulatory axis for tumor angiogenesis
The FASEB Journal, 2017Zonula occludens‐1 (ZO‐1) is a submembrane scaffolding protein that may display proinvasive functions when it relocates from tight junctions into the cytonuclear compartment. This article examines the functional involvement of ZO‐1 in CXCL8/IL‐8 chemokine expression in lung and breast tumor cells.
Lesage, Julien +10 more
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Diabetes-Related Changes in Rat Cerebral Occludin and Zonula Occludens-1 (ZO-1) Expression
Neurochemical Research, 2002The endothelial or epithelial tight junctions create a barrier to diffusion of solutes. Since experimental diabetes mellitus is associated with considerable alterations in the blood-brain barrier (BBB), it is possible that specific tight junction proteins may be altered in diabetes.
Joe M, Chehade +2 more
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Zonula occludens‐1 ZU5 domain contributes essential stabilizing interactions at the tight junction
The FASEB Journal, 2016Zonula occludens (ZO‐1) is a cytoplasmic scaffold protein that structurally and functionally tethers cytoskeletal components and membrane proteins at the tight junction. Interestingly, ZO‐1 has a poorly characterized ZU5 domain at the carboxy‐terminus that ZO‐2 and ZO‐3 proteins lack.
Jonathan M King +5 more
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Effect of hepatocyte growth factor on assembly of zonula occludens-1 protein at the plasma membrane
Journal of Cellular Physiology, 1998Hepatocyte growth factor (HGF) is a paracrine cytokine that influences epithelial morphogenesis by modulating cell-cell adhesion and cell polarity. We have examined the role of HGF in the tight junction (TJ) formation. We followed the assembly and disassembly at the plasma membrane of the major component of the TJ, zonula occludens-1 (ZO-1) protein ...
GRISENDI S., ARPIN M., CREPALDI, Tiziana
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