Results 51 to 60 of about 31,557 (233)

Decreased expression of zonula occludens-1 and occludin in the bladder urothelium of patients with interstitial cystitis/painful bladder syndrome

Journal of the Formosan Medical Association, 2014
Unique barrier properties of the urothelial surface membrane permit urine storage without contents leak into the bloodstream. Previous reports suggested that the bladder urothelial barrier might be compromised in interstitial cystitis/painful bladder ...
Jane-Dar Lee, Ming-Huei Lee
doaj   +1 more source

Zonula Occludens-1 Alters Connexin43 Gap Junction Size and Organization by Influencing Channel Accretion [PDF]

Molecular Biology of the Cell, 2005
Regulation of gap junction (GJ) organization is critical for proper function of excitable tissues such as heart and brain, yet mechanisms that govern the dynamic patterning of GJs remain poorly defined. Here, we show that zonula occludens (ZO)-1 localizes preferentially to the periphery of connexin43 (Cx43) GJ plaques.
Andrew W, Hunter, Ralph J, Barker, Ching, Zhu, Robert G, Gourdie   +3 more
openaire   +2 more sources

The Cx43 Carboxyl-Terminal Mimetic Peptide αCT1 Protects Endothelial Barrier Function in a ZO1 Binding-Competent Manner

Biomolecules, 2021
The Cx43 carboxyl-terminus (CT) mimetic peptide, αCT1, originally designed to bind to Zonula Occludens 1 (ZO1) and thereby inhibit Cx43/ZO1 interaction, was used as a tool to probe the role of Cx43/ZO1 association in regulation of epithelial/endothelial ...
Randy E. Strauss, Louisa Mezache, Rengasayee Veeraraghavan, Robert G. Gourdie   +3 more
doaj   +1 more source

Gliadin, zonulin and gut permeability: effects on celiac and non-celiac intestinal mucosa and intestinal cell lines. [PDF]

, 2006
OBJECTIVE: Little is known about the interaction of gliadin with intestinal epithelial cells and the mechanism(s) through which gliadin crosses the intestinal epithelial barrier. We investigated whether gliadin has any immediate effect on zonulin release
Carroccio A, Catassi C, CLEMENTE, MARIA GRAZIA, D'Agate C, Di Pierro M, Drago S, El Asmar R, Fasano A., Iacono G, Not T, Sapone A, Thakar M, Tripathi A, Zampini L   +13 more
core   +1 more source

Zonula Occludens-1, Occludin, and E-cadherin Protein Expression in Biliary Tract Cancers

Pathology & Oncology Research, 2009
The incidence of cholangiocarcinomas originating from intrahepatic and extrahepatic bile ducts, as well as of gallbladder carcinoma is increasing worldwide. The malignant transformation of biliary epithelia involves profound alterations of proteins in the intercellular junctions, among others zonula occludens-1 (ZO-1), occludin, and E-cadherin.
Németh, Zsuzsanna, Szász, Attila Marcell, Somorácz, Áron, Tátrai, Péter, Németh, J., Győrffy, Hajnalka, Szijártó, Attila, Kupcsulik, Péter, Kiss, András, Schaff, Zsuzsa   +9 more
openaire   +3 more sources

INVESTİGATİON OF ZONULA OCCLUDENS-1 PROTEİN LEVEL İN RECTUM TİSSUE AFTER RADİOTHERAPY

International Journal of Research -GRANTHAALAYAH, 2020
The transmembrane protein zonula occludens of rectal tissue has function to prevents the spread of bacterial toxins into the intestinal mucosa and to systemic circulation. But radiotherapy causes ablation of crypt cell proliferation, mitotic catastrophe, and apoptosis leading to gastrointestinal mucositis.
Cengiz Kurtman, Esra Gümüştepe, Serdağ Demirören, Fatma Firat, Şaban Çakır Gökçe, Kemal Özbilgin   +5 more
openaire   +2 more sources

Inhibitory Effects of Edaravone, a Free Radical Scavenger, on Cytokine-induced Hyperpermeability of Human Pulmonary Microvascular Endothelial Cells:A Comparison with Dexamethasone and Nitric Oxide Synthase Inhibitor [PDF]

, 2015
Lung hyperpermeability affects the development of acute respiratory distress syndrome (ARDS), but therapeutic strategies for the control of microvascular permeability have not been established.
Fujii, Yousuke, Morishima, Tsuneo, Nosaka, Nobuyuki, Saito, Yukie, Tsuge, Mitsuru, Tsukahara, Hirokazu, Yamada, Mutsuko, Yamashita, Nobuko, Yashiro, Masato   +8 more
core   +1 more source

The PDZ2 domain of zonula occludens-1 and -2 is a phosphoinositide binding domain [PDF]

Cellular and Molecular Life Sciences, 2009
Zonula occludens proteins (ZO) are postsynaptic density protein-95 discs large-zonula occludens (PDZ) domain-containing proteins that play a fundamental role in the assembly of tight junctions and establishment of cell polarity. Here, we show that the second PDZ domain of ZO-1 and ZO-2 binds phosphoinositides (PtdInsP) and we identified critical ...
Kris, Meerschaert, Moe Phyu, Tun, Eline, Remue, Ariane, De Ganck, Ciska, Boucherie, Berlinda, Vanloo, Gisèle, Degeest, Joël, Vandekerckhove, Pascale, Zimmermann, Nitin, Bhardwaj, Hui, Lu, Wonhwa, Cho, Jan, Gettemans   +12 more
openaire   +2 more sources

Neutralization of interleukin-17A alleviates burn-induced intestinal barrier disruption via reducing pro-inflammatory cytokines in a mouse model

Burns & Trauma, 2019
Background The intestinal barrier integrity can be disrupted due to burn injury, which is responsible for local and systemic inflammatory responses. Anti-inflammation strategy is one of the proposed therapeutic approaches to control inflammatory cascade ...
Yajun Song, Yang Li, Ya Xiao, Wengang Hu, Xu Wang, Pei Wang, Xiaorong Zhang, Jiacai Yang, Yong Huang, Weifeng He, Chibing Huang   +10 more
doaj   +1 more source

Protective effect of pericytes against vascular leakage in rats with hemorrhagic shock

Di-san junyi daxue xuebao, 2020
Objective To investigate the protective effect of pericytes (PCs) against vascular leakage in rats with hemorrhagic shock. Methods Sixty-four 12- to 24-week-old SD rats weighing 200~220 g were randomized equally into sham-operated group, hemorrhagic ...
HE Shuangshuang, ZHU Yu, ZHOU Henan, WANG Hongchen, LI Tao, LIU Liangming   +5 more
doaj   +1 more source